Common Genetic Variants of the Human Steroid 21-Hydroxylase Gene (CYP21A2) Are Related to Differences in Circulating Hormone Levels

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Hungarian Scientific Research Fund (OTKA, PD100648 (AP)) Technology Innovation Fund, National Developmental Agency (KTIA-AIK-2012-12-1-0010). AP is the recipient of a “Lendület” grant from the Hungarian Academy of Sciences

Role of trans-Planckian modes in cosmology

Motivated by the old trans-Planckian (TP) problem of inflationary cosmology, it has been conjectured that any consistent effective field theory should keep TP modes `hidden' behind the Hubble horizon, so as to prevent them from turning classical and thereby affecting macroscopic observations. In this paper we present two arguments against the Hubble horizon being a scale of singular significance as has been put forward in the TP Censorship Conjecture (TCC). First, refinements of TCC are presented that allow for the TP modes to grow beyond the horizon while still keeping the de-Sitter conjecture valid. Second, we show that TP modes can turn classical even well within the Hubble horizon, which, as such, negates this rationale behind keeping them from crossing it. The role of TP modes is known to be less of a problem in warm inflation, because fluctuations start out usually as classical. This allows warm inflation to be more resilient to the TP problem compared to cold inflation. To understand how robust this is, we identity limits where quantum modes can affect the primordial power spectrum in one specific case.Comment: 33 pages, comments welcome; v2: References updated, matches published versio

DNA methylation patterns of behavior-related gene promoter regions dissect the gray wolf from domestic dog breeds

A growing body of evidence highlights the relationship between epigenetics, especially DNA methylation, and population divergence as well as speciation. However, little is known about how general the phenomenon of epigenetics-wise separation of different populations is, or whether population assignment is, possible based on solely epigenetic marks. In the present study, we compared DNA methylation profiles between four different canine populations: three domestic dog breeds and their ancestor the gray wolf. Altogether, 79 CpG sites constituting the 65 so-called CpG units located in the promoter regions of genes affecting behavioral and temperamental traits (COMT, HTR1A, MAOA, OXTR, SLC6A4, TPH1, WFS1)-regions putatively targeted during domestication and breed selection. Methylation status of buccal cells was assessed using EpiTYPER technology. Significant inter-population methylation differences were found in 52.3% of all CpG units investigated. DNA methylation profile-based hierarchical cluster analysis indicated an unambiguous segregation of wolf from domestic dog. In addition, one of the three dog breeds (Golden Retriever) investigated also formed a separate, autonomous group. The findings support that population segregation is interrelated with shifts in DNA methylation patterns, at least in putative selection target regions, and also imply that epigenetic profiles could provide a sufficient basis for population assignment of individuals