On Exactly Marginal Deformations Dual to BB-Field Moduli of IIB Theory on SE5_5

The complex dimension of the space of exactly marginal deformations for quiver CFTs dual to IIB theory compactified on $Y^{p,q}$ is known to be generically three. Simple general formulas already exist for two of the exactly marginal directions in the space of couplings, one of which corresponds to the sum of the (inverse squared of) gauge couplings, and the other to the $\beta$-deformation. Here we identify the third exactly marginal direction, which is dual to the modulus $\int B_{2}$ on the gravity side. This identification leads to a relation between the field theory gauge couplings and the vacuum expectation value of the gravity modulus that we further support by a computation related to the chiral anomaly induced by added fractional branes. We also present a simple algorithm for finding similar exactly marginal directions in any CFT described by brane tiling, and demonstrate it for the quiver CFTs dual to IIB theory compactified on $L^{1,5,2}$ and the Suspended Pinch Point.Comment: 28 pages, JHEP style. v2: minor corrections, added references and acknowledgements. v3: a number of speculative comments regarding the application of the Konishi anomaly equation to our problem are removed. v4: the proposal in Eq. (2.4) added back as a conjectur

Cardiac manifestations of PRKAG2 mutation.

BACKGROUND:The Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2 (PRKAG2) cardiac syndrome is characterized by glycogen accumulation in the cardiac tissue. The disease presents clinically with hypertrophic cardiomyopathy (HCM), and it is often associated with conduction abnormalities. CASE PRESENTATION:A 23 year-old female with history of Wolff-Parkinson-White (WPW) and HCM presented for evaluation after an episode of Non-ST Elevation Myocardial Infarction (NSTEMI). The patient was found to have severe coronary bridging on angiography and underwent an unroofing of the left anterior descending artery (LAD). Due to the constellation of symptoms, the patient underwent genetic testing and a cardiac muscle biopsy. Genetic testing was significant for an Arg302Gln mutation in the PRKAG2 gene. Cardiac tissue biopsy revealed significant myocyte hypertrophy and large vacuoles with glycogen stores. CONCLUSION:The pathologic and genetics findings of our patient are consistent with PRKAG2 syndrome. Patients presenting with conduction abnormalities and suspected HCM should be considered for genetic testing to identify possible underlying genetic etiologies

Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors.

The pluripotent nature of human embryonic stem cells (hESCs) makes them convenient for deriving therapeutically relevant cells. Here we show using Wnt reporter hESC lines that the cells are heterogeneous with respect to endogenous Wnt signalling activity. Moreover, the level of Wnt signalling activity in individual cells correlates with differences in clonogenic potential and lineage-specific differentiation propensity. The addition of Wnt protein or, conversely, a small-molecule Wnt inhibitor (IWP2) reduces heterogeneity, allowing stable expansion of Wnt(high) or Wnt(low) hESC populations, respectively. On differentiation, the Wnt(high) hESCs predominantly form endodermal and cardiac cells, whereas the Wnt(low) hESCs generate primarily neuroectodermal cells. Thus, heterogeneity with respect to endogenous Wnt signalling underlies much of the inefficiency in directing hESCs towards specific cell types. The relatively uniform differentiation potential of the Wnt(high) and Wnt(low) hESCs leads to faster and more efficient derivation of targeted cell types from these populations

Does Clauser-Horne-Shimony-Holt Correlation or Freedman-Clauser Correlation lead to the largest violation of Bell's Inequality?

An inequality is deduced from Einstein's locality and a supplementary assumption. This inequality defines an experiment which can actually be performed with present technology to test local realism. Quantum mechanics violate this inequality a factor of 1.5. In contrast, quantum mechanics violates previous inequalities (for example, Clauser-Horne-Shimony-Holt inequality of 1969, Freedman-Clauser inequality of 1972, Clauser-Horne inequality of 1974) by a factor of $\sqrt 2$. Thus the magnitude of violation of the inequality derived in this paper is approximately $20.7$ larger than the magnitude of violation of previous inequalities. This result can be particularly important for the experimental test of locality.Comment: 15 pages, LaTeX file, no figure

Optimal eavesdropping in quantum cryptography with six states

A generalization of the quantum cryptographic protocol by Bennett and Brassard is discussed, using three conjugate bases, i.e. six states. By calculating the optimal mutual information between sender and eavesdropper it is shown that this scheme is safer against eavesdropping on single qubits than the one based on two conjugate bases. We also address the question for a connection between the maximal classical correlation in a generalized Bell inequality and the intersection of mutual informations between sender/receiver and sender/eavesdropper.Comment: 4 pages, 1 figur

Bell's inequality for n spin-s particles

The Mermin-Klyshko inequality for n spin-1/2 particles and two dichotomic observables is generalized to n spin-s particles and two maximal observables. It is shown that some multiparty multilevel Greenberger-Horne-Zeilinger states [A. Cabello, Phys. Rev. A 63, 022104 (2001)] maximally violate this inequality for any s. For a fixed n, the magnitude of the violation is constant for any s, which provides a simple demonstration and generalizes the conclusion reached by Gisin and Peres for two spin-s particles in the singlet state [Phys. Lett. A 162, 15 (1992)]. For a fixed s, the violation grows exponentially with n, which provides a generalization to any s of Mermin's conclusion for n spin-1/2 particles [Phys. Rev. Lett. 65, 1838 (1990)].Comment: REVTeX4, 4 page

Intravenous Paracetamol Versus Patient-Controlled Analgesia With Morphine for the Pain Management Following Diagnostic Knee Arthroscopy in Trauma Patients: A Randomized Clinical Trial

Background: Most patients undergoing outpatient surgeries have the unpleasant experience of high level pain after surgery. Compared with open surgeries, arthroscopic procedures are less painful; however, inadequate pain management could be associated with significant concerns. Opioids alone or in combination with local anesthetics are frequently used for diminishing postoperative pain using intravenous or epidural infusion pumps. Despite morphine various disadvantages, it is commonly used for controlling pain after surgery. Objectives: The aim of this study was to compare intravenous paracetamol and patient-controlled analgesia (PCA) with morphine for the pain management following diagnostic knee arthroscopy in trauma patients. Patients and Methods: Sixty trauma patients who were scheduled to undergo knee arthroscopy were randomly divided into two groups. Patients immediately received intravenous infusion of 1 g paracetamol within 15 minutes after surgery and every 6 hours to 24 hours in the paracetamol group. The patient-controlled analgesia group received morphine through PCA infusion pump at 2 mL/h base rate and 1mL bolus every 15 minutes. Pain level, nausea and vomiting, and sedation were measured and recorded during entering the recovery, 15 and 30 minutes after entering the recovery, 2, 6, and 24 hours after starting morphine pump infusion in the morphine and paracetamol in the paracetamol groups. Results: There was no significant difference regarding the pain level at different times after entering the recovery between the two groups. No one from the paracetamol group developed drug complications. However, 22.3% in the PCA morphine suffered from postoperative nausea; there was a statistically significant difference regarding the sedation level, nausea, and vomiting at various times between the two groups. Conclusions: Intravenous administration of paracetamol immediately after knee arthroscopy improved postoperative pain, decreased analgesic administration, maintained stable hemodynamic parameters, had no complications related to opiates, no nausea and vomiting, and increased patient satisfaction and comfort in comparison to PCA with morphine

Successful Tricuspid Valve Replacement in a Patient with Severe Pulmonary Arterial Hypertension and Preserved Right Ventricular Systolic Function

A 56-year-old patient with severe pulmonary hypertension developed severe tricuspid regurgitation, right-sided heart failure, and congestive hepatopathy. She was transferred for possible lung transplant and/or tricuspid valve surgery. Clinical and echocardiographic assessment provided confidence that acute tricuspid valve failure was responsible for the decompensation and that tricuspid valve replacement despite pulmonary hypertension could be performed

Quantum Bit Commitment with a Composite Evidence

Entanglement-based attacks, which are subtle and powerful, are usually believed to render quantum bit commitment insecure. We point out that the no-go argument leading to this view implicitly assumes the evidence-of-commitment to be a monolithic quantum system. We argue that more general evidence structures, allowing for a composite, hybrid (classical-quantum) evidence, conduce to improved security. In particular, we present and prove the security of the following protocol: Bob sends Alice an anonymous state. She inscribes her commitment $b$ by measuring part of it in the + (for $b = 0$) or $\times$ (for $b=1$) basis. She then communicates to him the (classical) measurement outcome $R_x$ and the part-measured anonymous state interpolated into other, randomly prepared qubits as her evidence-of-commitment.Comment: 6 pages, minor changes, journal reference adde