Energy-sharing asymmetries in ionization by positron impact

The triply differential cross section of molecular hydrogen for ionization by 50 eV positrons has been determined, for the first time, for both the ejected electron in coincidence with the remnant ion and for the scattered projectile. Asymmetries in the energy sharing between the two light particles in the final state are observed, with the electron spectrum being shifted to significantly lower (and the scattered positron to correspondingly higher) energies than expected. A similar shape is observed in the case of the ejected electron spectrum from a helium target at the same excess energy

Infinite impulse response modal filtering in visible adaptive optics

Diffraction limited resolution adaptive optics (AO) correction in visible wavelengths requires a high performance control. In this paper we investigate infinite impulse response filters that optimize the wavefront correction: we tested these algorithms through full numerical simulations of a single-conjugate AO system comprising an adaptive secondary mirror with 1127 actuators and a pyramid wavefront sensor (WFS). The actual practicability of the algorithms depends on both robustness and knowledge of the real system: errors in the system model may even worsen the performance. In particular we checked the robustness of the algorithms in different conditions, proving that the proposed method can reject both disturbance and calibration errors

Approximating High-Dimensional Dynamic Models: Sieve Value Function Iteration

Many dynamic problems in economics are characterized by large state spaces which make both computing and estimating the model infeasible. We introduce a method for approximating the value function of high-dimensional dynamic models based on sieves and establish results for the: (a) consistency, (b) rates of convergence, and (c) bounds on the error of approximation. We embed this method for approximating the solution to the dynamic problem within an estimation routine and prove that it provides consistent estimates of the model's parameters. We provide Monte Carlo evidence that our method can successfully be used to approximate models that would otherwise be infeasible to compute, suggesting that these techniques may substantially broaden the class of models that can be solved and estimated.

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response.

Hyperproliferative keratinocytes induced by trauma, hyperkeratosis and/or inflammation display molecular signatures similar to those of palmoplantar epidermis. Inherited gain-of-function mutations in RHBDF2 (encoding iRHOM2) are associated with a hyperproliferative palmoplantar keratoderma and squamous oesophageal cancer syndrome (termed TOC). In contrast, genetic ablation of rhbdf2 in mice leads to a thinning of the mammalian footpad, and reduces keratinocyte hyperproliferation and migration. Here, we report that iRHOM2 is a novel target gene of p63 and that both p63 and iRHOM2 differentially regulate cellular stress-associated signalling pathways in normal and hyperproliferative keratinocytes. We demonstrate that p63-iRHOM2 regulates cell survival and response to oxidative stress via modulation of SURVIVIN and Cytoglobin, respectively. Furthermore, the antioxidant compound Sulforaphane downregulates p63-iRHOM2 expression, leading to reduced proliferation, inflammation, survival and ROS production. These findings elucidate a novel p63-associated pathway that identifies iRHOM2 modulation as a potential therapeutic target to treat hyperproliferative skin disease and neoplasia

From "Gomorrah Domain" to "Don Peppe Diana Lands". A Southern Italian Experience of Work-Based Liberation, Community Networking, and Well Being

The article describes working experiences in relation to empowering activities, which have been carried out in a local community in the province of Caserta (in Southern Italy), a place characterized by the widespread presence of organized criminal groups. In this study, workplace is intended as a community network aimed at the promotion of coscientization, liberation, and well-being. Specifically, this paper features initiatives and projects aimed at establishing new community values through a re-construction of a work-based social system standing against criminal clans, which tend to dominate not only economical transactions but also civil life

Culture and Community Interactions: Essentials for understanding in a globalised world

"Introduction to the issue

Observations of Isolated Neutron Stars with the ESO Multi-Conjugate Adaptive Optics Demonstrator

High-energy observations have unveiled peculiar classes of isolated neutron stars which, at variance with radio pulsars, are mostly radio silent and not powered by the star rotation. Among these objects are the magnetars, hyper-magnetized neutron stars characterized by transient X-ray/gamma-ray emission, and neutron stars with purely thermal, and in most cases stationary, X-ray emission (a.k.a., X-ray dim isolated neutron stars or XDINSs). While apparently dissimilar in their high-energy behavior and age, both magnetars and XDINSs have similar periods and unusually high magnetic fields. This suggests a tantalizing scenario where the former evolve into the latter.Discovering so far uninvestigated similarities between the multi-wavelength properties of these two classes would be a further step forward to establish an evolutionary scenario. A most promising channels is the near infrared (NIR) one, where magnetars are characterized by a distinctive spectral flattening with respect to the extrapolation of the soft X-ray spectrum.We observed the two XDINSs RX J0420.0-5022 and RX J1856.5-3754 with the Multi-Conjugate Adaptive Optics Demonstrator (MAD) at the Very Large Telescope (VLT) as part of the instrument guaranteed time observations program, to search for their NIR counterparts. Both RX J1856.5-3754 and RX J0420.0-5022 were not detected down to K_s ~20 and Ks ~21.5, respectively. In order to constrain the relation between XDINSs and magnetars it would be of importance to perform deeper NIR observations. A good candidate is 1RXS J214303.7+065419 which is the XDINS with the highest inferred magnetic field.Comment: Accepted for publication in Astronomy and Astrophysic

Disaster Resilience Assessment of Building and Transportation System

The paper presents a new methodology to assist decision-makers in the management of critical events such as earthquakes evaluating the recovery time, and the resilience index of a building system that is a component of the physical infrastructure dimension of the PEOPLES Resilience framework. The interdependencies between building system and transportation network in term of accessibility are modeled. Finally, the methodology has been implemented in a software and has been applied in two case studies: (a) the old medieval center of L’Aquila town and (b) the Treasure Island in the San Francisco Bay area