Industrias del Paleolítico antiguo en el valle medio del Guadalquivir

El trabajo responde al objetivo de participar en la reconstrucción de la secuencia paleolítica y geoarqueológica de la cuenca media y baja del Guadalquivir, tarea iniciada en la Universidad de Sevilla a principios de la década de los ochenta del pasado siglo por los Dres. Vallespí y Díaz del Olmo, y que continúa en la actualidad. El trabajo se ha centrado en el sector en que confluyen Genil y Guadalquivir, en el entorno de la localidad de Palma del Río, provincia de Córdoba (Andalucía, España). Se trata de una zona de vital importancia para el conocimiento de las primeras ocupaciones prehistóricas de nuestra región, pues a los materiales cuarcíticos que, procedentes de Sierra Morena, aporta el gran colector andaluz, utilizados en los modos de talla achelenses de toda la cuenca, se une el sílex que arrastra su principal afluente desde las cordilleras Béticas, empleado en los modos de talla adscritos al Paleolítico Medio

Planck Spectroscopy and the Quantum Noise of Microwave Beam Splitters

We use a correlation function analysis of the field quadratures to characterize both the black body radiation emitted by a 50 Ohm load resistor and the quantum properties of two types of beam splitters in the microwave regime. To this end, we first study vacuum fluctuations as a function of frequency in a Planck spectroscopy experiment and then measure the covariance matrix of weak thermal states. Our results provide direct experimental evidence that vacuum fluctuations represent the fundamental minimum quantum noise added by a beam splitter to any given input signal.Comment: 5 pages, 4 figure

Capacitated Trees, Capacitated Routing, and Associated Polyhedra

We study the polyhedral structure of two related core combinatorial problems: the subtree cardinalityconstrained minimal spanning tree problem and the identical customer vehicle routing problem. For each of these problems, and for a forest relaxation of the minimal spanning tree problem, we introduce a number of new valid inequalities and specify conditions for ensuring when these inequalities are facets for the associated integer polyhedra. The inequalities are defined by one of several underlying support graphs: (i) a multistar, a "star" with a clique replacing the central vertex; (ii) a clique cluster, a collection of cliques intersecting at a single vertex, or more generally at a central" clique; and (iii) a ladybug, consisting of a multistar as a head and a clique as a body. We also consider packing (generalized subtour elimination) constraints, as well as several variants of our basic inequalities, such as partial multistars, whose satellite vertices need not be connected to all of the central vertices. Our development highlights the relationship between the capacitated tree and capacitated forest polytopes and a so-called path-partitioning polytope,and shows how to use monotone polytopes and a set of simple exchange arguments to prove that valid inequalities are facets

Materiales calcolíticos procedentes de "La Longuera" (El Viso, Córdoba)

El norte de la provincia de Córdoba conforma un marco de enorme interés para el análisis de los primeros momentos de la metalurgia en Andalucía Occidental dada la excepcional riqueza en recursos mineros, y muy especialmente cupríferos que encierra su subsuelo. A este hecho viene a sumarse su singularidad geográfica como lugar de interrelación entre los desarrollos culturales coetáneos en el valle del Guadalquivir, Extremadura y zona occidental de la Submeseta sur. Conscientes de estos hechos, nos planteamos hace varios años un programa de investigación que, partiendo de una serie de prospecciones sistemáticas, nos permitiera una primera y sólida aproximación a la dinámica del Calcolítico en estas tierras cordobesas, labor que ya ha dado sus primeros frutos (MURILLO, 1986,1986 b, 1987) y en la que debe inscribirse el presente trabajo

Dual-path state reconstruction scheme for propagating quantum microwaves and detector noise tomography

Quantum state reconstruction involves measurement devices that are usually described by idealized models, but not known in full detail in experiments. For weak propagating microwaves, the detection process requires linear amplifiers which obscure the signal with random noise. Here, we introduce a theory which nevertheless allows one to use these devices for measuring all quadrature moments of propagating quantum microwaves based on cross-correlations from a dual-path amplification setup. Simultaneously, the detector noise properties are determined, allowing for tomography. We demonstrate the feasibility of our novel concept by proof-of-principle experiments with classical mixtures of weak coherent microwaves.Comment: 11 pages, 3 figure

Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1

Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS) is the leading cause of non-traumatic neurological disability in young adults. Immune mediated destruction of myelin and oligodendrocytes is considered the primary pathology of MS, but progressive axonal loss is the major cause of neurological disability. In an effort to understand microglia function during CNS inflammation, our laboratory focuses on the fractalkine/CX3CR1 signaling as a regulator of microglia neurotoxicity in various models of neurodegeneration. Fractalkine (FKN) is a transmembrane chemokine expressed in the CNS by neurons and signals through its unique receptor CX3CR1 present in microglia. During experimental autoimmune encephalomyelitis (EAE), CX3CR1 deficiency confers exacerbated disease defined by severe inflammation and neuronal loss. The CX3CR1 human polymorphism I249/M280 present in ∼20% of the population exhibits reduced adhesion for FKN conferring defective signaling whose role in microglia function and influence on neurons during MS remains unsolved. The aim of this study is to assess the effect of weaker signaling through hCX3CR1I249/M280 during EAE. We hypothesize that dysregulated microglial responses due to impaired CX3CR1 signaling enhance neuronal/axonal damage. We generated an animal model replacing the mouse CX3CR1 locus for the hCX3CR1I249/M280 variant. Upon EAE induction, these mice exhibited exacerbated EAE correlating with severe inflammation and neuronal loss. We also observed that mice with aberrant CX3CR1 signaling are unable to produce FKN and ciliary neurotrophic factor during EAE in contrast to wild type mice. Our results provide validation of defective function of the hCX3CR1I249/M280 variant and the foundation to broaden the understanding of microglia dysfunction during neuroinflammation. © 2018 Cardona et al

Sequence learning in Associative Neuronal-Astrocytic Network

The neuronal paradigm of studying the brain has left us with limitations in both our understanding of how neurons process information to achieve biological intelligence and how such knowledge may be translated into artificial intelligence and its most brain-derived branch, neuromorphic computing. Overturning our fundamental assumptions of how the brain works, the recent exploration of astrocytes is revealing that these long-neglected brain cells dynamically regulate learning by interacting with neuronal activity at the synaptic level. Following recent experimental evidence, we designed an associative, Hopfield-type, neuronal-astrocytic network and analyzed the dynamics of the interaction between neurons and astrocytes. We show that astrocytes were sufficient to trigger transitions between learned memories in the neuronal component of the network. Further, we mathematically derived the timing of the transitions that was governed by the dynamics of the calcium-dependent slow-currents in the astrocytic processes. Overall, we provide a brain-morphic mechanism for sequence learning that is inspired by, and aligns with, recent experimental findings. To evaluate our model, we emulated astrocytic atrophy and showed that memory recall becomes significantly impaired after a critical point of affected astrocytes was reached. This brain-inspired and brain-validated approach supports our ongoing efforts to incorporate non-neuronal computing elements in neuromorphic information processing.Comment: 8 pages, 5 figure

Disentangling astroglial physiology with a realistic cell model in silico

Electrically non-excitable astroglia take up neurotransmitters, buffer extracellular K+ and generate Ca2+ signals that release molecular regulators of neural circuitry. The underlying machinery remains enigmatic, mainly because the sponge-like astrocyte morphology has been difficult to access experimentally or explore theoretically. Here, we systematically incorporate multi-scale, tri-dimensional astroglial architecture into a realistic multi-compartmental cell model, which we constrain by empirical tests and integrate into the NEURON computational biophysical environment. This approach is implemented as a flexible astrocyte-model builder ASTRO. As a proof-of-concept, we explore an in silico astrocyte to evaluate basic cell physiology features inaccessible experimentally. Our simulations suggest that currents generated by glutamate transporters or K+ channels have negligible distant effects on membrane voltage and that individual astrocytes can successfully handle extracellular K+ hotspots. We show how intracellular Ca2+ buffers affect Ca2+ waves and why the classical Ca2+ sparks-and-puffs mechanism is theoretically compatible with common readouts of astroglial Ca2+ imaging