A Swift study of long-term changes in the X-ray flaring properties of Sagittarius A

The radiative counterpart of the supermassive black hole at the Galactic Centre, Sagittarius A∗, displays flaring emission in the X-ray band atop a steady, quiescent level. Flares are also observed in the near-infrared band. The physical process producing the flares is not fully understood and it is unclear if the flaring rate varies, although some recent works suggest it has reached unprecedented variability in recent years. Using over a decade of regular X-ray monitoring of Neil Gehrels Swift Observatory, we studied the variations in count rate of Sgr A∗ on time-scales of years. We decomposed the X-ray emission into quiescent and flaring emission, modelled as a constant and power-law process, respectively. We found that the complete, multiyear data set cannot be described by a stationary distribution of flare fluxes, while individual years follow this model better. In three of the ten studied years, the data is consistent with a purely Poissonian quiescent distribution, while for 5 yr, only an upper limit of the flare flux distribution parameter could be determined. We find that these possible changes cannot be explained fully by the different number of observations per year. Combined, these results are instead consistent with a changing flaring rate of Sgr A∗, appearing more active between 2006-2007 and 2017-2019, than between 2008-2012. Finally, we discuss this result in the context of flare models and the passing of gaseous objects, and discuss the extra statistical steps taken, for instance, to deal with the background in the Swift observations

A Worldwide Survey of Activities and Practices in Clinical Islet of Langerhans Transplantation

A global online survey was administered to 69 islet transplantation programs, covering 84 centers and 5 networks. The survey addressed questions on program organization and activity in the 2000–2020 period, including impact on activity of national health care coverage policies. We obtained full data from 55 institutions or networks worldwide and basic activity data from 6 centers. Additional data were obtained from alternative sources. A total of 94 institutions and 5 networks was identified as having performed islet allotransplantation. 4,365 islet allotransplants (2,608 in Europe, 1,475 in North America, 135 in Asia, 119 in Oceania, 28 in South America) were reported in 2,170 patients in the survey period. From 15 centers active at the start of the study period, the number of simultaneously active islet centers peaked at 54, to progressively decrease to 26 having performed islet allotransplants in 2020. Notably, only 16 centers/networks have done >100 islet allotransplants in the survey period. Types of transplants performed differed notably between North America and the rest of the world, in particular with respect to the near-absence of simultaneous islet-kidney transplantation. Absence of heath care coverage has significantly hampered transplant activity in the past years and the COVID-19 pandemic in 2020