Memorandum From Alvey A. Adee to Francis Mairs Huntington-Wilson, April 13, 1909

The document is a typed memorandum from the Second Assistant Secretary of State to Francis Mairs Huntington-Wilson on the topic of immigrant laborers and the need for regulations and conditions imposed by a special Department of Labor.https://digitalcommons.ursinus.edu/fmhw_immigration/1001/thumbnail.jp

Letter From Alvey A. Adee to Henry A. Barnhart, August 10, 1909

The document is a carbon copy of a typed letter from the Second Assistant Secretary of State to Henry A. Barnhart concerning information requested by F. A. Miller about a possible visit by General Carlos Garcia Velez.https://digitalcommons.ursinus.edu/fmhw_other/1159/thumbnail.jp

Nuclear rupture at sites of high curvature compromises retention of DNA repair factors.

The nucleus is physically linked to the cytoskeleton, adhesions, and extracellular matrix-all of which sustain forces, but their relationships to DNA damage are obscure. We show that nuclear rupture with cytoplasmic mislocalization of multiple DNA repair factors correlates with high nuclear curvature imposed by an external probe or by cell attachment to either aligned collagen fibers or stiff matrix. Mislocalization is greatly enhanced by lamin A depletion, requires hours for nuclear reentry, and correlates with an increase in pan-nucleoplasmic foci of the DNA damage marker γH2AX. Excess DNA damage is rescued in ruptured nuclei by cooverexpression of multiple DNA repair factors as well as by soft matrix or inhibition of actomyosin tension. Increased contractility has the opposite effect, and stiff tumors with low lamin A indeed exhibit increased nuclear curvature, more frequent nuclear rupture, and excess DNA damage. Additional stresses likely play a role, but the data suggest high curvature promotes nuclear rupture, which compromises retention of DNA repair factors and favors sustained damage

A Behavioral Economic Analysis of Different Reinforcers: Sound-Clips Versus Points Exchangeable for Money

Human operant studies frequently use points exchangeable for money as reinforcers. Some studies employ more immediately consumable reinforcers to emulate properties of food reinforcers. This study examined demand for points/money and for sound-clips to compare their economic characteristics. Across four participants, demand was often higher and less elastic for points/money than for sounds. During subsequent exposures at each response requirement, demand for sounds often decreased to a greater degree than demand for points/money. Thus, sound-clips seem less durable than points/money across prices and across repeated exposure to the same price. Response rates for points/money were often higher than for sounds, suggesting that reinforcers that generate higher response rates may be less elastic than reinforcers that generate lower response rates

Letter From Alvey A. Adee to Edward M. Skinner, October 1, 1909

The document is a carbon copy of a typed letter from Alvey A. Adee to Edward M. Skinner concerning Francis Mairs Huntington Wilson\u27s attendance at the Annual Dinner of the Chicago Association of Commerce.https://digitalcommons.ursinus.edu/fmhw_other/1174/thumbnail.jp

Letter From Alvey A. Adee to Francis Mairs Huntington-Wilson, January 8, 1919

A handwritten letter from Alvey A. Adee to Francis Mairs Huntington-Wilson, dated January 8, 1919. Within, Adee thanks Wilson for his Christmas greeting and sends his well wishes for the New Year.https://digitalcommons.ursinus.edu/fmhw_commerce_documents/1006/thumbnail.jp

Letter From Alvey A. Adee to Francis Mairs Huntington-Wilson, September 21, 1905

In this typed letter from Alvey Adee to Francis Mairs Huntington-Wilson, Adee gives permission for the publication of Wilson\u27s article entitled The American Foreign Service.https://digitalcommons.ursinus.edu/fmhw_early_career/1020/thumbnail.jp

Letter From Alvey A. Adee to William F. Sands, September 4, 1909

The document is a carbon copy of a typed letter from the Assistant Secretary of State to William F. Sands regarding his assignment and financial suggestions to the Republic of Guatemala as envoy extraordinaire and minister plenipotentiary.https://digitalcommons.ursinus.edu/fmhw_other/1167/thumbnail.jp

Letter From Alvey A. Adee to Theodore E. Bingham, September 1, 1909

The document is a carbon copy of a typed letter from Alvey A. Adee to General Theodore E. Bingham concerning the criminal case of Francis C. Bailey.https://digitalcommons.ursinus.edu/fmhw_other/1166/thumbnail.jp

Letter From Alvey A. Adee to Mabel T. Boardman, August 31, 1909

The document is a carbon copy of a typed letter from the Acting Secretary of State Alvey A. Adee to Mabel T. Boardman concerning American Red Cross aid for the flood in Monterrey, Mexico.https://digitalcommons.ursinus.edu/fmhw_other/1164/thumbnail.jp