Performing celebrity motherhood on Twitter: courting homage and (momentary) disaster - the case of Peaches Geldof

It sickens me to see just how far the cult of celebrity and super fandom has come when grown women are passing their own kids round. I hate the world sometimes. (@peaches-g) (cited in Halliday 2013) This quote was part of a Twitter message that Peaches Geldof published in November 2013. In the message she also named the two women who had allowed the Lost Prophets singer Ian Watkins to abuse their babies. What became key elements focused upon by journalists in the newspaper debate that followed her subsequent deletion of the message and apology were the purpose of Twitter as a form of communication, and the celebritisation of public discourse. This tweet was constructed as an empty-headed, gossipy, childish and hence feminised intervention into the public sphere.1 Also tied up with this debate was the ongoing narrative of the ‘non-functionality’ of celebrity culture and its ‘reflexive exhibitionism’ (Hyde 2013). Yet Geldof had, until this point, used a combination of Twitter and Instagram to enact a self-transformation from girlhood to motherhood that had drawn critical affirmation from both media pundits and female followers via the social media sites. It is this image of motherhood that has informed the reporting of her sudden death of a heroin overdose at the age of 25 on 7 April 2014

Observational methods for COVID-19 vaccine effectiveness research:an empirical evaluation and target trial emulation

Background:There are scarce data on best practices to control for confounding in observational studies assessing vaccine effectiveness to prevent COVID-19. We compared the performance of three well-established methods [overlap weighting, inverse probability treatment weighting and propensity score (PS) matching] to minimize confounding when comparing vaccinated and unvaccinated people. Subsequently, we conducted a target trial emulation to study the ability of these methods to replicate COVID-19 vaccine trials.Methods:We included all individuals aged ≥75 from primary care records from the UK [Clinical Practice Research Datalink (CPRD) AURUM], who were not infected with or vaccinated against SARS-CoV-2 as of 4 January 2021. Vaccination status was then defined based on first COVID-19 vaccine dose exposure between 4 January 2021 and 28 January 2021. Lasso regression was used to calculate PS. Location, age, prior observation time, regional vaccination rates, testing effort and COVID-19 incidence rates at index date were forced into the PS. Following PS weighting and matching, the three methods were compared for remaining covariate imbalance and residual confounding. Last, a target trial emulation comparing COVID-19 at 3 and 12 weeks after first vaccine dose vs unvaccinated was conducted.Results:Vaccinated and unvaccinated cohorts comprised 583 813 and 332 315 individuals for weighting, respectively, and 459 000 individuals in the matched cohorts. Overlap weighting performed best in terms of minimizing confounding and systematic error. Overlap weighting successfully replicated estimates from clinical trials for vaccine effectiveness for ChAdOx1 (57%) and BNT162b2 (75%) at 12 weeks.Conclusion:Overlap weighting performed best in our setting. Our results based on overlap weighting replicate previous pivotal trials for the two first COVID-19 vaccines approved in Europe

Clinical and genetic risk factors for acute incident venous Thromboembolism in ambulatory patients with COVID-19.

Importance: The risk of venous thromboembolism (VTE) in ambulatory COVID-19 is controversial. In addition, the association of vaccination with COVID-19-related VTE and relevant clinical and genetic risk factors remain to be elucidated. Objective: To quantify the association between ambulatory COVID-19 and short-term risk of VTE, study the potential protective role of vaccination, and investigate clinical and genetic risk factors for post-COVID-19 VTE. Design, Setting, and Participants: This population-based cohort study of patients with COVID-19 from UK Biobank included participants with SARS-CoV-2 infection that was confirmed by a positive polymerase chain test reaction result between March 1, 2020, and September 3, 2021, who were then propensity score matched to COVID-19-naive people during the same period. Participants with a history of VTE who used antithrombotic drugs (1 year before index dates) or tested positive in hospital were excluded. Exposures: First infection with SARS-CoV-2, age, sex, ethnicity, socioeconomic status, obesity, vaccination status, and inherited thrombophilia. Main Outcomes and Measures: The primary outcome was a composite VTE, including deep vein thrombosis or pulmonary embolism, which occurred 30 days after the infection. Hazard ratios (HRs) with 95% CIs were calculated using cause-specific Cox models. Results: In 18 818 outpatients with COVID-19 (10 580 women [56.2%]; mean [SD] age, 64.3 [8.0] years) and 93 179 matched uninfected participants (52 177 women [56.0%]; mean [SD] age, 64.3 [7.9] years), the infection was associated with an increased risk of VTE in 30 days (incidence rate of 50.99 and 2.37 per 1000 person-years for infected and uninfected people, respectively; HR, 21.42; 95% CI, 12.63-36.31). However, risk was substantially attenuated among the fully vaccinated (HR, 5.95; 95% CI, 1.82-19.5; interaction P = .02). In patients with COVID-19, older age, male sex, and obesity were independently associated with higher risk, with adjusted HRs of 1.87 (95% CI, 1.50-2.33) per 10 years, 1.69 (95% CI, 1.30-2.19), and 1.83 (95% CI, 1.28-2.61), respectively. Further, inherited thrombophilia was associated with an HR of 2.05 (95% CI, 1.15-3.66) for post-COVID-19 VTE. Conclusions and Relevance: In this population-based cohort study of patients with COVID-19, ambulatory COVID-19 was associated with a substantially increased risk of incident VTE, but this risk was greatly reduced in fully vaccinated people with breakthrough infection. Older age, male sex, and obesity were clinical risk factors for post-COVID-19 VTE; factor V Leiden thrombophilia was additionally associated with double the risk, comparable with the risk of 10-year aging. These findings may reinforce the need for vaccination, inform VTE risk stratification, and call for targeted VTE prophylaxis strategies for unvaccinated outpatients with COVID-19

Towards domestic cooking efficiency: A case study on burger pan frying using experimental and computational results

It is well known that the use of efficient domestic cooking appliances and equipment can not only save energy, but also improve the quality of the food being prepared. This work raises the question of whether cooking procedures can also contribute to this energy efficiency. Focusing on burger pan frying, experimental data were used to develop a model able to predict cooking outcomes under different power levels supplied by an induction hob. The proposed model takes into account not only the heat consumed by water evaporation in the contact region but also the shrinkage process of the hamburger. A new formulation based on the multiplicative decomposition of the strain deformation gradient is proposed to describe the observed decoupling between weight and volume loss during the process. The model properly predicts temperature, moisture loss and shrinkage, and allows elucidation of the effects of supplying different amounts of energy on the final water content

Evangelical Visitor- October 2, 1911. Vol. XXV. No. 20.

Evangelical Visitor published in Harrisburg, Pa., for the exposition of true, practical piety and devoted to the spread of evangelical truths and the unity of the church. Published in the interest of the church of the Brethren in Christ on October 2, 1911. Vol. XXV. No. 20

Impact of a National Enhanced Recovery After Surgery Programme on Patient Outcomes of Primary total Knee Replacement: an Interrupted Time Series Analysis from “The National Joint Registry of England, Wales, Northern Ireland and the Isle of Man”

Objective We aimed to test whether a national Enhanced Recovery After Surgery (ERAS) Programme in total knee replacement (TKR) had an impact on patient outcomes. Design Natural-experiment (April 2008-December 2016). Interrupted time-series regression assessed impact on trends before-during-after ERAS implementation. Setting Primary operations from the UK National Joint Registry were linked with Hospital Episode Statistics data which contains inpatient episodes undertaken in NHS trusts in England, and PROMs. Participants Patients undergoing primary planned TKR aged ≥18 years. Intervention ERAS implementation (April 2009-March 2011). Outcomes Regression coefficients of monthly means of LOS, bed day costs, change in Oxford knee scores (OKS) 6-months after surgery, complications (at 6 months), and rates of revision surgeries (at 5 years). Results 486,579 primary TKRs were identified. Overall LOS and bed-day costs decreased from 5.8 days to 3.7 and from £7607 to £5276, from April 2008 to December 2016. OKS change improved from 15.1 points in April 2008 to 17.1 points in December 2016. Complications decreased from 4.1 % in April 2008 to 1.7 % March 2016. 5-year revision rates remained stable at 4.8 per 1000 implants years in April 2008 and December 2011. After ERAS, declining trends in LOS and bed costs slowed down; OKS improved, complications remained stable, and revisions slightly increased. Conclusions Different secular trends in outcomes for patients having TKR have been observed over the last decade. Although patient outcomes are better than a decade ago ERAS did not improve them at national level

Are people following hip and knee arthroplasty at greater risk of experiencing a fall and fracture? Data from the Osteoarthritis Initiative

Introduction: Falls are a major challenge for older people and are a significant source of mortality and morbidity. There has been uncertainty as to whether people with total hip (THA) or knee (TKA) arthroplasty have a greater risk of falls and associated fractures. This analysis was to explore this question with a large community dataset. Materials and Methods: Data from all people enrolled onto the US Osteoarthritis Initiative programme who had undergone a THA (n=104) or TKA (n=165), within a 12 month period, were compared to those who had not undergone an arthroplasty (n=4631). Data was collected on: the number of participants who reported a fall within a 12 month period; the frequency of falls in this period; and whether a fracture was sustained during this period. Odd ratios were calculated for the probability of experiencing a fall or fracture between the groups. Results: There was no statistical difference in falls between people following THA (OR 0.90; 95% CI: 0.58 to 1.41) or TKA (OR: 0.95; 0.67 to 1.35) compared to a non-arthroplasty cohort. Whilst there was no statistical difference in fracture risk between people following TKA compared to non-arthroplasty individuals (OR: 1.25; 95% CI: 0.57 to 2.70), those who underwent THA had a 65% lower chance of experiencing a fracture in the initial 12 post-operative months compared to the non-THA cohort (OR 0.35; 95% CI: 0.19 to 0.65; p<0.01). Conclusions: There appears a lower chance of experiencing a fracture for people following THA compared to those who have not