Peripartum cardiomyopathy with a history of doxorubicin therapy: case report & review of literature

Background: Peripartum cardiomyopathy and doxorubicin-induced cardiomyopathy are well described conditions but there is little description in the literature of both occurring together. Case: A 29 year old G1P0 with a remote history of childhood chondroblastic osteosarcoma treated with high-dose doxorubicin therapy who developed minimally symptomatic cardiomyopathy during her pregnancy with ejection fraction reaching as low as 20-30%. She delivered via primary low-transverse cesarean section at 37 weeks complicated by uterine atony with an unremarkable recovery. Cardiomyopathy was treated with metoprolol and enalapril and she achieved ejection fraction of 44% at one year follow-up with complete return to baseline activity. Discussion: We present a woman with a history of doxorubicin therapy who developed peripartum cardiomyopathy and recovered symptomatically after one year. Although treatment of peripartum cardiomyopathy regardless of etiology is well-defined, there are few reports and no standard guidelines for special considerations in pregnant women with a history of doxorubicin therapy, a topic that may warrant further investigation

Peripartum cardiomyopathy with a history of doxorubicin therapy: case report & review of literature

Background: Peripartum cardiomyopathy and doxorubicin-induced cardiomyopathy are well described conditions but there is little description in the literature of both occurring together. Case: A 29 year old G1P0 with a remote history of childhood chondroblastic osteosarcoma treated with high-dose doxorubicin therapy who developed minimally symptomatic cardiomyopathy during her pregnancy with ejection fraction reaching as low as 20-30%. She delivered via primary low-transverse cesarean section at 37 weeks complicated by uterine atony with an unremarkable recovery. Cardiomyopathy was treated with metoprolol and enalapril and she achieved ejection fraction of 44% at one year follow-up with complete return to baseline activity. Discussion: We present a woman with a history of doxorubicin therapy who developed peripartum cardiomyopathy and recovered symptomatically after one year. Although treatment of peripartum cardiomyopathy regardless of etiology is well-defined, there are few reports and no standard guidelines for special considerations in pregnant women with a history of doxorubicin therapy, a topic that may warrant further investigation

Integrated Alternative Source of Energy System with Grid Substation

This paper discusses the modeling, simulation and optimization of integrated alternative source of energy system with grid substation. When there is a lack of energy in grid substation to meet the demand of customer load then alternative source of energy compensates energy deficiency and after that if there is excess energy available then remaining energy is stored in battery bank or sells to grid according to need. In another case when required energy is not generated by alternative sources then remaining energy is purchased from the grid and if the grid substation hasn't available these remaining energy to meet the customer load demand during the peak load then stored battery energy is also active. The size of integrated alternative source of energy system may vary from few hundred watts to ten or hundreds of MW. The possible sources of alternative energy like solar, wind and biomass are considered under this paper. Study location, Muzaffarpur district of Bihar (India), is taken because there is good potential of energy generation from alternative source of energy and still there is no any wind and solar energy power plant. The modeling and simulation of the system is done by using HOMER software and the software solve the optimization problem to minimize the total cost of system and maximum utilization of alternative source of energy

The 5f localization/delocalization in square and hexagonal americium monolayers: A FP-LAPW electronic structure study

The electronic and geometrical properties of bulk americium and square and hexagonal americium monolayers have been studied with the full-potential linearized augmented plane wave (FP-LAPW) method. The effects of several common approximations are examined: (1) non-spin polarization (NSP) vs. spin polarization (SP); (2) scalar-relativity (no spin-orbit coupling (NSO)) vs. full-relativity (i.e., with spin-orbit (SO) coupling included); (3) local-density approximation (LDA) vs. generalized-gradient approximation (GGA). Our results indicate that both spin polarization and spin orbit coupling play important roles in determining the geometrical and electronic properties of americium bulk and monolayers. A compression of both americium square and hexagonal monolayers compared to the americium bulk is also observed. In general, the LDA is found to underestimate the equilibrium lattice constant and give a larger total energy compared to the GGA calculations. While spin orbit coupling shows a similar effect on both square and hexagonal monolayer calculations regardless of the model, GGA versus LDA, an unusual spin polarization effect on both square and hexagonal monolayers is found in the LDA results as compared with the GGA results. The 5f delocalization transition of americium is employed to explain our observed unusual spin polarization effect. In addition, our results at the LDA level of theory indicate a possible 5f delocalization could happen in the americium surface within the same Am II (fcc crystal structure) phase, unlike the usually reported americium 5f delocalization which is associated with crystal structure change. The similarities and dissimilarities between the properties of an Am monolayer and a Pu monolayer are discussed in detail.Comment: 22 pages, 8 figure

Interactive Content Diversity and User Exploration in Online Movie Recommenders: A Field Experiment

Recommender systems often struggle to strike a balance between matching users' tastes and providing unexpected recommendations. When recommendations are too narrow and fail to cover the full range of users' preferences, the system is perceived as useless. Conversely, when the system suggests too many items that users don't like, it is considered impersonal or ineffective. To better understand user sentiment about the breadth of recommendations given by a movie recommender, we conducted interviews and surveys and found out that many users considered narrow recommendations to be useful, while a smaller number explicitly wanted greater breadth. Additionally, we designed and ran an online field experiment with a larger user group, evaluating two new interfaces designed to provide users with greater access to broader recommendations. We looked at user preferences and behavior for two groups of users: those with higher initial movie diversity and those with lower diversity. Among our findings, we discovered that different level of exploration control and users' subjective preferences on interfaces are more predictive of their satisfaction with the recommender.Comment: International Journal of Human Computer Interactio

Understanding tradeoffs in incremental deployment of new network architectures

Despite the plethora of incremental deployment mechanisms proposed, rapid adoption of new network-layer protocols and architectures remains difficult as reflected by the widespread lack of IPv6 traffic on the Internet. We show that all de-ployment mechanisms must address four key questions: How to select an egress from the source network, how to select an ingress into the destination network, how to reach that egress, and how to reach that ingress. By creating a de-sign space that maps all existing mechanisms by how they answer these questions, we identify the lack of existing mech-anisms in part of this design space and propose two novel approaches: the “4ID ” and the “Smart 4ID”. The 4ID mech-anism utilizes new data plane technology to flexibly decide when to encapsulate packets at forwarding time. The Smart 4ID mechanism additionally adopts an SDN-style control plane to intelligently pick ingress/egress pairs based on a wider view of the local network. We implement these mech-anisms along with two widely used IPv6 deployment mech-anisms and conduct wide-area deployment experiments over PlanetLab. We conclude that Smart 4ID provide better overall performance and failure semantics, and that inno-vations in the data plane and control plane enable straight-forward incremental deployment

An Integrated Framework to Model Cellular Phenotype as a Component of Biochemical Networks

Identification of regulatory molecules in signaling pathways is critical for understanding cellular behavior. Given the complexity of the transcriptional gene network, the relationship between molecular expression and phenotype is difficult to determine using reductionist experimental methods. Computational models provide the means to characterize regulatory mechanisms and predict phenotype in the context of gene networks. Integrating gene expression data with phenotypic data in transcriptional network models enables systematic identification of critical molecules in a biological network. We developed an approach based on fuzzy logic to model cell budding in Saccharomyces cerevisiae using time series expression microarray data of the cell cycle. Cell budding is a phenotype of viable cells undergoing division. Predicted interactions between gene expression and phenotype reflected known biological relationships. Dynamic simulation analysis reproduced the behavior of the yeast cell cycle and accurately identified genes and interactions which are essential for cell viability

Consistency vs. Availability in Distributed Real-Time Systems

In distributed applications, Brewer's CAP theorem tells us that when networks become partitioned (P), one must give up either consistency (C) or availability (A). Consistency is agreement on the values of shared variables; availability is the ability to respond to reads and writes accessing those shared variables. Availability is a real-time property whereas consistency is a logical property. We have extended the CAP theorem to relate quantitative measures of these two properties to quantitative measures of communication and computation latency (L), obtaining a relation called the CAL theorem that is linear in a max-plus algebra. This paper shows how to use the CAL theorem in various ways to help design real-time systems. We develop a methodology for systematically trading off availability and consistency in application-specific ways and to guide the system designer when putting functionality in end devices, in edge computers, or in the cloud. We build on the Lingua Franca coordination language to provide system designers with concrete analysis and design tools to make the required tradeoffs in deployable software.Comment: 12 pages. arXiv admin note: text overlap with arXiv:2109.0777

Combined local-density and dynamical mean field theory calculations for the compressed lanthanides Ce, Pr, and Nd

This paper reports calculations for compressed Ce (4f^1), Pr (4f^2), and Nd (4f^3) using a combination of the local-density approximation (LDA) and dynamical mean field theory (DMFT), or LDA+DMFT. The 4f moment, spectra, and the total energy among other properties are examined as functions of volume and atomic number for an assumed face-centered cubic (fcc) structure.Comment: 15 pages, 9 figure