Auricular Graft vs. Chemoterapy in the Managment of Craniomandibular Joint Ankylosis

ABSTRACT A variety of techniques for the management of craniomandibular ankylosis have been described. However, no single technique has proved entirely satisfactory. These techniques pose a significant challenge due to a high incidence of recurrence. Aim: The aim of this study was to evaluate and compare between the interpositional auricular graft and local application of chemotherapy procedures. Patients/methods : The study has been used on 31 patients with true TMJ ankylosis (18 had unilateral and13 had bilateral ankylosis with average age ranged between 12 and 41). Two procedures for the management of TMJ ankylosis were done. Group (1) included 16 patients were subjected to small gap arthroplasty and topical application chemotherapeutic agent having antiproliferative property to suppress fibrous proliferation and vascular ingrowth between the osteotomy sites. Group (11) included 15 patients were subjected to interpositional arthroplasty using auricular graft of the ipsilateral side. All patients were examined and followed clinically and radiologically using panoramic view, CT and MRI, after the operation for a period extended to 4 years to confirm absence of recurrence. All patients had no recurrence after surgery. Results : Considerable improvement in maximal incisal opening (33 mm) was noted in all patients during the follow up period. Conclusion : The study concluded that both techniques provided satisfactory results. However, chemical application of chemotherapeutic agent was found to be superior in some aspects; no mandibular shifting during the movement, elimination of grafting problems and saving surgical time

The effect of excessive coffee consumption, in relation to diterpenes levels of medium-roasted coffee, on non-high-density lipoprotein cholesterol level in healthy men

This study was designed to determine the levels of coffee oil and diterpenes and evaluate the correlation between the effect of excessive roasted coffee consumption on non-high-density lipoprotein cholesterol (non-HDL) and the roasting degree effect on the levels of coffee oil and diterpenes extracted from Coffea arabica. The coffee oil and diterpenes were extracted using soxhlet and liquid-liquid extraction. Sixty-six healthy normolipidemic male participants were assigned for this study which consisted of two stages. The first stage is the coffee abstaining stage where subjects were requested to abstain from drinking coffee for 2 weeks. The second stage is the coffee drinking stage which consisted of groups (the control group and coffee-drinking group). The levels of TC, TG, LDL-C, HDL-C, and non-HDL were determined in all participants before and after the experiment. The results indicated that the coffee roasting degree demonstrated a significant increase in the levels of coffee oil and diterpenes ranging from 9.31% (green coffee) to 15.64% (dark roast) and from 0.205% (green coffee) to 0.300% (dark roast) for diterpenes. In conclusion, the current study revealed that excessive consumption of medium roasted coffee was associated with elevated non-HDL levels in normotensive nonsmoker healthy men which might be attributed to the positive association between the degree of roasting and diterpenes levels