ROLE OF SPORTS ACTIVITIES IN THE SOCIALIZATION PROCESS OF STREET CHILDREN (A PILOT STUDY)

This article deals with the socio- cultural and socio- economical features of the street children and the effect of sport activities upon their socialization. The study was carried out upon 133 children who live or work in the streets of Ankara with or without home fitting perfectly well in the description of “street children” who had been involved in sports at various degrees before... the data were collected by the use of the 69 question socialization scale developed by Şahan (2007). The data obtained were evaluated by the use of SPSS statistical software. The data were first subjected to frequency analysis and listed in tabular manner. The percentage of the variables in the sample was determined and the features of the sample were first subjected to a general evaluation process. Then the analysis process to be applied to hypotheses was started and the raw data were evaluated by the use of Mann Whitney U test and Kruskal-Wallis Nonparametric Test. It was concluded that here was not a statistically significant difference between the socialization levels of the children interested and not interested in sports according to gender and the income levels of the families. On the other hand, there was significant difference in the socialization levels of the children if the interest in sports and family income parameters are considered together.  Article visualizations

The prognostic impact of comorbidity, nutritional and performance status on patients with diffuse large B cell lymphoma

Background: The aim of the study was to investigate the impact of nutritional status, comorbidity, and performance status on patients with diffuse large B-cell lymphoma (DLBCL). Methods: A retrospective study was conducted on 112 DLBCL patients who were diagnosed at our center between 2009 and 2018. Demographic and disease characteristics and laboratory test results were recorded. Assessments were made using the age-adjusted Charlson comorbidity index (CCI-A) for comorbidity, albumin level for nutritional status, and Eastern Cooperative Oncology Group (ECOG) score for performance status. Results: The mean age of the patients was found to be 62.63 ± 15.16 years. The ECOG score of 65 patients (69.1%) was in the range of 0-1. The mean follow-up time of the patients was determined to be 25.24 ± 25.11 months, and at the end of the follow-up period, 64 patients (57.1%) were survivors. The progression-free survival (PFS), overall survival (OS), and 5-year OS rates of those with CCI-A > 4 were found to be significantly lower than those with CCI-A score ≤4 (P < 0.05). As a result of the Cox-Regression (Backward: LR method) analysis, ECOG and albumin levels were found to be independent risk factors for both OS and PFS (P < 0.05). Conclusion: This study demonstrated that CCI-A, ECOG, and nutritional status are independent prognostic markers for DLBCL patients. Initial evaluation of these patients should include all these parameters, which are easily available at the time of diagnosis

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

<div><p>Cutaneous squamous cell carcinomas are a common form of highly mutated keratinocyte skin cancers that are of particular concern in immunocompromised patients. Here we report on the efficacy of topically applied MS-275, a clinically used histone deacetylase inhibitor, for the treatment and management of this disease. At 2 mg/kg, MS-275 significantly decreased tumor burden in an SKH-1 hairless mouse model of UVB radiation-induced skin carcinogenesis. MS-275 was cell permeable as a topical formulation and induced histone acetylation changes in mouse tumor tissue. MS-275 was also effective at inhibiting the proliferation of patient derived cutaneous squamous cell carcinoma lines and was particularly potent toward cells isolated from a regional metastasis on an immunocompromised individual. Our findings support the use of alternative routes of administration for histone deacetylase inhibitors in the treatment of high-risk squamous cell carcinoma which may ultimately lead to more precise delivery and reduced systemic toxicity.</p></div

Degradation Science: Mesoscopic Evolution and Temporal Analytics of Photovoltaic Energy Materials

Based on recent advances in nanoscience, data science and the availability of massive real-world datastreams, the mesoscopic evolution of mesoscopic energy materials can now be more fully studied. The temporal evolution is vastly complex in time and length scales and is fundamentally challenging to scientific understanding of degradation mechanisms and pathways responsible for energy materials evolution over lifetime. We propose a paradigm shift towards mesoscopic evolution modeling, based on physical and statistical models, that would integrate laboratory studies and real-world massive datastreams into a stress/mechanism/response framework with predictive capabilities. These epidemiological studies encompass the variability in properties that affect performance of material ensembles. Mesoscopic evolution modeling is shown to encompass the heterogeneity of these materials and systems, and enables the discrimination of the fast dynamics of their functional use and the slow and/or rare events of their degradation. We delineate paths forward for degradation science

Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial

BackgroundAnterior cruciate ligament (ACL) rupture is a common debilitating injury that can cause instability of the knee. We aimed to investigate the best management strategy between reconstructive surgery and non-surgical treatment for patients with a non-acute ACL injury and persistent symptoms of instability.MethodsWe did a pragmatic, multicentre, superiority, randomised controlled trial in 29 secondary care National Health Service orthopaedic units in the UK. Patients with symptomatic knee problems (instability) consistent with an ACL injury were eligible. We excluded patients with meniscal pathology with characteristics that indicate immediate surgery. Patients were randomly assigned (1:1) by computer to either surgery (reconstruction) or rehabilitation (physiotherapy but with subsequent reconstruction permitted if instability persisted after treatment), stratified by site and baseline Knee Injury and Osteoarthritis Outcome Score—4 domain version (KOOS4). This management design represented normal practice. The primary outcome was KOOS4 at 18 months after randomisation. The principal analyses were intention-to-treat based, with KOOS4 results analysed using linear regression. This trial is registered with ISRCTN, ISRCTN10110685, and ClinicalTrials.gov, NCT02980367.FindingsBetween Feb 1, 2017, and April 12, 2020, we recruited 316 patients. 156 (49%) participants were randomly assigned to the surgical reconstruction group and 160 (51%) to the rehabilitation group. Mean KOOS4 at 18 months was 73·0 (SD 18·3) in the surgical group and 64·6 (21·6) in the rehabilitation group. The adjusted mean difference was 7·9 (95% CI 2·5–13·2; p=0·0053) in favour of surgical management. 65 (41%) of 160 patients allocated to rehabilitation underwent subsequent surgery according to protocol within 18 months. 43 (28%) of 156 patients allocated to surgery did not receive their allocated treatment. We found no differences between groups in the proportion of intervention-related complications.InterpretationSurgical reconstruction as a management strategy for patients with non-acute ACL injury with persistent symptoms of instability was clinically superior and more cost-effective in comparison with rehabilitation management

Stigmatization and Exclusion Mechanisms Against Roma People: The Sample of Uşak City

Uşak kentinde 2014-2016 yılları arasında yapmış olduğumuz araştırmalarda kentte yaşayan üç ayrı Çingene grubunun varlığına denk geldik. Bu gruplar Rom (Demirci), Lom (Elekçi) ve Abdal gruplarıydı. Makale içinde belirteceğimiz nedenlerle tüm bu grupları Roman olarak ifade ettik. Çalışmamızın merkezinde Uşak'ta yaşayan bu grupların damgalanma ve toplumsal dışlanma mekanizmalarına nasıl maruz kaldıkları, bu gruplara ilişkin sosyal içerme ve entegrasyonun nasıl olabileceği konuları yer almaktadır. Çalışmamızda Goffman'ın damga teorisi; gözlem, mülakat, odak grup gibi nitel araştırma yöntemleriyle ele alınmıştırWe found three groups of gypsy people live in Uşak city during our research between 2014-2016. These groups are called Rom People (Demirci), Lom People (Elek&ccedil;i) and Abdals. We called all these groups as Roma People according to some reasons. Our focus is stigmatization and exclusion mechanisms against to Roma People in Uşak and how their social inclusion and integration could be implemented. We conduct our research via stigmatization theory of Goffman in quantitaive technics such as observation, interview and focus group studies