[Psychoneurotische person in der Zahnarztlicher praxis]

Autori žele upozoriti na problem psihoneurotičnih pacijenata, koji se javljaju u sve većem broju tražeći stomatološku zaštitu, kao i na način postupanja s njima. Zalažu se za stručni pristup psihoneurotičnom pacijentu, koji bi bez sumnje olakšao rad stomatologa.The authors wish to emphasize the problem of the growing number of psychoneurotic pationts who are appearying for stomatological treatment and the manner or methods for their acceptance. They are interceding for professional approach towards psychoneurotic patients which would undoubtedly be of great help to dental surgeons.Die Autoren wollen die Problematik der psychoneurotischen Patienten, die in immer grosserer Zahl stomatologischen Schutz suchen, hervorheben und gleichzeitig auf die entsprechende Behandlungsweise hinweisen. Sie treten fur eine fachmannische Zuwendung zum psychoneurotischen Patienten ein, was die Arbeit des Stomatologen ohne Zweifel erleichtert

Jovens urbanos: marcos conceituais e metodológicos

Esta publicação traz reflexões sobre o contexto das juventudes e as proposições conceituais e metodológicas do Programa Jovens Urbanos

In vitro and biodistribution examinations of Tc-99m-labelled doxorubicin-loaded nanoparticles

BACKGROUND: Nanoparticles represent promising drug carrier systems. In the case of cytostatics such as doxorubicin, carrier colloid systems as human serum albumin (HSA) nanoparticles, may increase their therapeutic efficiency and decrease their side-effects (toxicity) and any potential multidrug resistance. In the present study, doxorubicin, as a widely used antineoplastic agent, was incorporated into the matrix of human serum albumin and three different particle-sized doxorubicin-loaded HSA nanoparticles were prepared, using a previously described desolvation method. Our objective was to find out if different particle sizes of colloid carriers can allow regarding the given cytostatic agent. MATERIAL AND METHODS: The three prepared nanoparticles were labelled using technetium (Tc-99m) and were tested for their physicochemical colloidal quality, fluctuations, and radiochemical stability. Biodistribution of different-sized radiolabelled colloids were determined by means of scintigraphic imaging studies in healthy male Wistar rats. Images were taken by gamma camera at several times and organ uptakes were estimated by quantitative ROI analysis. RESULTS: In vitro measurements showed that more than 95% of doxorubicin proportion was permanently adsorbed to human serum albumin. Radiolabelled doxorubicin-loaded particles had high-degree and durable labelling efficiency and particle size stability. Biodistribution results had a close correlation to earlier described results of radiocolloids in similar particle size ranges. In vivo examinations verified that colloid carriers have insignificant size fluctuations after an intravenous application and they show the proper distribution according to their particle size. CONCLUSIONS: Our investigations verified that different and stable particle sizes make drug carrier HSA nanoparticles possible to apply different drug targeting in a potential clinical use. Nuclear Med Rev 2011; 14, 2: 55–6

3D-Hydrogen Analysis of Ferromagnetic Microstructures in Proton Irradiated Graphite

Recently, magnetic order in highly oriented pyrolytic graphite (HOPG) induced by proton broad- and microbeam irradiation was discovered. Theoretical models propose that hydrogen could play a major role in the magnetism mechanism. We analysed the hydrogen distribution of pristine as well as irradiated HOPG samples, which were implanted to micrometer-sized spots as well as extended areas with various doses of 2.25 MeV protons at the Leipzig microprobe LIPSION. For this we used the sensitive 3D hydrogen microscopy system at the Munich microprobe SNAKE. The background hydrogen level in pristine HOPG is determined to be less than 0.3 at-ppm. About 4.8e15 H-atoms/cm^2 are observed in the near-surface region (4 um depth resolution). The depth profiles of the implants show hydrogen located within a confined peak at the end of range, in agreement with SRIM Monte Carlo simulations, and no evidence of diffusion broadening along the c-axis. At sample with microspots, up to 40 at-% of the implanted hydrogen is not detected, providing support for lateral hydrogen diffusion.Comment: accepted for publication in Nucl. Instr. and Met