Bone metastasis in breast cancer: The story of RANK-Ligand

AbstractThe primary cellular mechanism responsible for osteolytic bone metastases is osteoclastic activation. Preclinical models have shown that breast cancer cells can produce parathyroid hormone-related protein (PTHrP), and other osteolytic molecules, which stimulate excessive osteoclastic bone resorption and establishment of osteolytic lesions. It has been shown that PTHrP by itself cannot directly induce osteoclastic activation, but it mediates its effect through the transactivation of RANK-ligand (RANKL) gene on stromal and osteoblastic cells. Accordingly RANKL up-regulation has been considered as a prerequisite in virtually all conditions of cancer induced bone destruction. Hence, therapeutic targeting of RANKL seems to be a rational approach to treat or even to prevent the process of bone metastases.In this review, we will focus on the unique patho-physiological aspects related to the evolution of bone metastases in breast cancer, emphasizing the pivotal role of RANKL and some other key molecules in osteoclastic bone resorption. We will discuss the therapeutic interventions using bisphosphonates and RANKL inhibitors in patients with bone metastases and the outcome of this novel approach

A study of the Haor areas of Sylhet-Mymensing districts with ERTS imageries (winter crop estimation)

There are no author-identified significant results in this report

A new species of the genus Gomphomastax Brunner von Wattenwyl (Orthoptera: Eumastacidae: Gomphomastacinae) from Indian Kashmir

A new species, Gomphomastax nigrovittata Usmani, from Kashmir is described and illustrated. In addition to conventional morphological characters, genitalic structures are also studied. A key to known species of Gomphomastax from Indian Kashmir is given

pregnancy in breast cancer survivors a need for proper counseling

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Optimized Forwarding for Wireless Sensor Networks by Fuzzy Inference System

For the flat wireless sensor networks, we investigate the optimization problem of the routing path based on the metrics: distance, power and link usage to maximize the lifetime of the sensor networks. We employ the well known fuzzy inference systems (FIS) for the selection of the best node, from the candidate nodes, in order to forward packet to the sink. Simulation results show that network lifetime can be improved by employing the optimized routing protocol

treatment of metastatic breast cancer during pregnancy we need to talk

Metastatic breast cancer during pregnancy is a challenging situation. The literature yield in this topic is poor given the rarity of the disease. Management strategies should be discussed in a multidisciplinary manner and each case have to be counselled separately and informed about the pros and cons of different treatment options. Here, we report a case of metastatic breast cancer initially diagnosed during pregnancy. We discuss the clinical course and dilemmas governing the management decisions

Mobile Computing in Physics Analysis - An Indicator for eScience

This paper presents the design and implementation of a Grid-enabled physics analysis environment for handheld and other resource-limited computing devices as one example of the use of mobile devices in eScience. Handheld devices offer great potential because they provide ubiquitous access to data and round-the-clock connectivity over wireless links. Our solution aims to provide users of handheld devices the capability to launch heavy computational tasks on computational and data Grids, monitor the jobs status during execution, and retrieve results after job completion. Users carry their jobs on their handheld devices in the form of executables (and associated libraries). Users can transparently view the status of their jobs and get back their outputs without having to know where they are being executed. In this way, our system is able to act as a high-throughput computing environment where devices ranging from powerful desktop machines to small handhelds can employ the power of the Grid. The results shown in this paper are readily applicable to the wider eScience community.Comment: 8 pages, 7 figures. Presented at the 3rd Int Conf on Mobile Computing & Ubiquitous Networking (ICMU06. London October 200

Recent Advances in Preparation and Testing Methods of Engine-Based Nanolubricants: A State-of-the-Art Review

Reducing power losses in engines is considered a key parameter of their efficiency improvement. Nanotechnology, as an interface technology, is considered one of the most promising strategies for this purpose. As a consumable liquid, researchers have studied nanolubricants through the last decade as potential engine oil. Nanolubricants were shown to cause a considerable reduction in the engine frictional and thermal losses, and fuel consumption as well. Despite that, numerous drawbacks regarding the quality of the processed nanolubricants were discerned. This includes the dispersion stability of these fluids and the lack of actual engine experiments. It has been shown that the selection criteria of nanoparticles to be used as lubricant additives for internal combustion engines is considered a complex process. Many factors have to be considered to investigate and follow up with their characteristics. The selection methodology includes tribological and rheological behaviours, thermal stability, dispersion stability, as well as engine performance. Through the last decade, studies on nanolubricants related to internal combustion engines focused only on one to three of these factors, with little concern towards the other factors that would have a considerable effect on their final behaviour. In this review study, recent works concerning nanolubricants are discussed and summarized. A complete image of the designing parameters for this approach is presented, to afford an effective product as engine lubricant

Biology of breast cancer in young women

Breast cancer arising at a young age is relatively uncommon, particularly in the developed world. Several studies have demonstrated that younger patients often experience a more aggressive disease course and have poorer outcome compared to older women. Expression of key biomarkers, including endocrine receptors, HER2 and proliferation markers, appears to be different in younger patients and young women are more likely to harbor a genetic predisposition. Despite these differences, little research to date has focused on the biology of these tumors to refine prognosis, and potentially direct treatment strategies, which remain similar to those offered to older patients. Accumulating evidence suggests the differences in breast stroma in younger patients and changes that occur with pregnancy and breastfeeding likely contribute to the different biology of these tumors. Reproductive behaviors appear to impact the biology of tumors developing later in life. In addition, tumors arising during or shortly following pregnancy appear to exhibit unique biological features. In this review, we discuss our emerging understanding of the biology of breast cancer arising at a young age at both the pathologic and the genomic level. We elucidate the potential role of genomic signatures, the impact of pregnancy and breastfeeding on breast cancer biology, and how even current knowledge might advance the clinical management of young breast cancer patients