Some Formulas for Legendre Functions Induced by the Poisson Transform

Using the Poisson transform, which maps any homogeneous and infinitely differentiable function on a cone into a corresponding function on a hyperboloid, we derive some integral representations of the Legendre functions

Symbol as a means of cognition of consciousness in the works by M.K. Mamardashvili

The article reveals the specificity of understanding the symbol as a means of cognition of consciousness in the works by M.K. Mamardashvili. It demonstrates the difference between his interpretation and the analogues existing in neo-Kantianism and Russian Silver Age metaphysics (P.A. Florensky, A.F. Losev, etc). The symbol of consciousness is seen as an “empty shape”, a transcendental issue, through which transcendence generating man as a spiritual and moral being becomes possible Mamardashvili’s criticism of the naturalized theory of ideas (“Platonism”) is analyzed. The idea itself is seen as a symbol of consciousness, a unit of its description. The entire history of philosophy is considered from the same point of view

On the anniversary of Lyudmila Andreevna Bespalova, an outstanding breeder, Vice President of the Vavilov Society of Geneticists and Breeders (VOGiS), Academician of the Russian Academy of Sciences (RAS)

April 2, 2022 marks the anniversary of Lyudmila Andreevna Bespalova, an Academician of the Russian Academy of Sciences, one of the prominent wheat and triticale breeders, the author of many varieties introduced into agricultural practice both in our country and abroad, which are cultivated in areas encompassing millions of hectares, thus making a significant contribution to solving the global food security problem. Lyudmila A. Bespalova is a recognized classic in the field of wheat breeding and seed production, she has published over 300 scientific papers, and received about 120 copyright certificates and patents. Acad. Bespalova is a bright representative of domestic breeders, who maintains the traditions of one of the largest scientific schools and takes an active part in the life of the community of geneticists and breeders in this country by training young specialists and increasing the prestige of and demand for the profession of a breeder

Bioinformatics benefits from Siberia: on the anniversary of Nikolay Aleksandrovich Kolchanov, Academician of the Russian Academy of Sciences (RAS)

January 9, 2022 marks the 75th anniversary of Nikolai Aleksandrovich Kolchanov, Doctor of Biological Sciences, Professor, Academician of the Russian Academy of Sciences, Scientific Leader of the Federal Research Center the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, First Vice-President of the Vavilov Society of Geneticists and Breeders. Acad. N.A. Kolchanov is a prominent specialist in the field of bioinformatics and systems computational biology, under whose guidance the largest domestic scientific school in this area has formed and received global development. He is the author and co-author of about 700 publications in domestic and foreign press, holder of 18 copyright certificates and 8 patents. For almost 20 years, Acad. Kolchanov is the Head and Professor of the Department of Information Biology with the Faculty of Natural Sciences of Novosibirsk State University. He supervised the work of 12 doctoral and 2 senior doctorate students. His students, who work in leading domestic and foreign scientific centers, are the pride of Russian science and make a significant contribution to the world level of development of modern bioinformatics at the global level

On the anniversary of Academician Nikolay Kazimirovich Yankovsky

June 21, 2023, marks the 75th anniversary of RAS Academician Nikolay Kazimirovich Yankovsky, an eminent specialist in the field of general and molecular genetics and biotechnology. Nikolay Kazimirovich has published more than 170 scientific papers, has nine patents, trained six Doctors and 19 Candidates of Science. He is a laureate of the USSR Council of Ministers Prize and several other awards. Nikolay Kazimirovich carries out extensive editorial work, being the Editor-in-Chief of the Journal “Genetics” and a member of editorial boards of a few other specialized periodicals. N.K. Yankovsky is also known as a major organizer in science; in 2006-2016 he held the position of Director of the Institute of General Genetics of the Russian Academy of Sciences, and currently he is the Scientific Director of this Institute. Nikolay Kazimirovich carries out extensive educational work, being the author of dozens of popular scientific publications and presentations in the mass media. It is impossible to overestimate the contribution of N.K. Yankovsky into the work of the Russian genetic community in the rank of the first Vice-President of the Vavilov Society of Geneticists and Breeders, in which position he has always been and still is a generator of new ideas and an active fighter for the ideals of genetic science. Friends and associates – Russian geneticists and breeders, congratulate Nikolay Kazimirovich on his anniversary and wish him achieving new creative successes, grateful apprentices, enthusiasm and inexhaustible energy in solving large-scale challenges of genetics on a national and global scales

On the anniversary of Academician Lyubov Vladimirovna Khotyleva

March 12, 2023 is the anniversary of Lyubov Vladimirovna Khotyleva, Academician of the National Academy of Sciences (NAS) of Belarus, one of the world’s largest specialists in the field of genetics of agricultural plants. She published more than 400 scientific works, received 18 copyright certificates for varieties and inventions. Lyubov V. Khotyleva directed the Institute of Genetics and Cytology of the NAS of Belarus for almost a quarter of a century, raised several generations of scientists. Under her leadership, six Doctors and 43 Candidates of Sciences defended their theses. In different years, Lyubov Vladimirovna was the Vice-President of the N.I. Vavilov All-Union Society of Geneticists and Breeders, the President of the Belarus Society of Geneticists and Breeders, was a member of the presidium of the Higher Attestation Commission (VAK) of Belarus and VAK of Russia, was an Academician-Secretary of the Biological Department of the NAS of Belarus. L.V. Khotyleva carries out important scientific and organizational work as one of the prominent experts in the field of plant genetics, member of the editorial boards of several specialized periodicals

The man, the plant, and the insect: shooting host specificity determinants in Serratia marcescens pangenome

IntroductionSerratia marcescens is most commonly known as an opportunistic pathogen causing nosocomial infections. It, however, was shown to infect a wide range of hosts apart from vertebrates such as insects or plants as well, being either pathogenic or growth-promoting for the latter. Despite being extensively studied in terms of virulence mechanisms during human infections, there has been little evidence of which factors determine S. marcescens host specificity. On that account, we analyzed S. marcescens pangenome to reveal possible specificity factors.MethodsWe selected 73 high-quality genome assemblies of complete level and reconstructed the respective pangenome and reference phylogeny based on core genes alignment. To find an optimal pipeline, we tested current pangenomic tools and obtained several phylogenetic inferences. The pangenome was rich in its accessory component and was considered open according to the Heaps’ law. We then applied the pangenome-wide associating method (pan-GWAS) and predicted positively associated gene clusters attributed to three host groups, namely, humans, insects, and plants.ResultsAccording to the results, significant factors relating to human infections included transcriptional regulators, lipoproteins, ABC transporters, and membrane proteins. Host preference toward insects, in its turn, was associated with diverse enzymes, such as hydrolases, isochorismatase, and N-acetyltransferase with the latter possibly exerting a neurotoxic effect. Finally, plant infection may be conducted through type VI secretion systems and modulation of plant cell wall synthesis. Interestingly, factors associated with plants also included putative growth-promoting proteins like enzymes performing xenobiotic degradation and releasing ammonium irons. We also identified overrepresented functional annotations within the sets of specificity factors and found that their functional characteristics fell into separate clusters, thus, implying that host adaptation is represented by diverse functional pathways. Finally, we found that mobile genetic elements bore specificity determinants. In particular, prophages were mainly associated with factors related to humans, while genetic islands-with insects and plants, respectively.DiscussionIn summary, functional enrichments coupled with pangenomic inferences allowed us to hypothesize that the respective host preference is carried out through distinct molecular mechanisms of virulence. To the best of our knowledge, the presented research is the first to identify specific genomic features of S. marcescens assemblies isolated from different hosts at the pangenomic level

THE INTERRELATION BETWEEN SUP45 AND VTS1 IN SACCHAROMYCES CEREVISIAE

Overexpression of VTS1 gene in Saccharomyces cerevisiae leads to suppression of nonsense-mutations ade1-14UGA and trp1-289UAG, which enhances growth of yeast cells on media without adenine and tryptophan. We showed that suppression was caused by downregulation of SUP45 gene, which encodes translation termination factor eRF1.Работа выполнена за счет средств тематического плана НИР СПбГУ и при поддержке ФЦП «Научные и научно-педагогические кадры инновационной России» на 2009–2013 годы (Госконтракт № П1354) гранта администрации Санкт-Петербурга для студентов и аспирантов

The first scientific forum «Genetic resources of Russia» - on legal regulation in the field of bioresources and biological collections

The first scientific forum «Genetic Resources of Russia» took place in Saint Petersburg on 21-24 June 2022. The Forum brought together more than 500 specialists from more than 100 research institutions and universities of the Russian Federation. A round table «Regulations and standards of work with bio-resource collections» was organized within the framework of the Forum in connection with the relevance to create the legislation base for the work with biological collections and regulation of the activities of bioresource centres in the Russian Federation. This publication presents the outcomes of the Forum and its resolution relating to the legal regulation of biological collections