\u3cem\u3eIn Vitro\u3c/em\u3e Evaluation of Different Protocols for Preventing Microleakage of Fissure Sealants Placed Following Saliva Contamination

Purpose: To evaluate the effect of different enamel conditioning protocols and their re-application on the microleakage of fissure sealants placed following saliva contamination. Study design: The study included 156 human third molars in 16 subgroups (2×4×2) under two main groups (sealant type): Group A- hydrophobic resin sealant, 3M Clinpro™ Sealant; Group B- hydrophilic resin sealant, Ultraseal XT Hydro. Each group was then divided according to the type of surface conditioning; 1- Er,Cr:YSSG laser etching, 2- acid-etching, 3- acid-etching+etch-and-rinse adhesive (Prime&Bond® One Select) and 4- self-etching adhesive (Clearfil™SE Bond). After contaminating the conditioned occlusal enamel surfaces with artificial saliva, fissure sealant was applied in half of the specimens (a), whereas in the other half, (b) the respective surface conditioning was repeated and then fissure sealant was placed. Following thermocycling, the samples were immersed in basic fuchsin, sectioned, and dye penetration was quantitatively assessed with ImageJ. Two-way ANOVA and Bonferroni post-hoc tests were used for statistical analyses (p Results: The least microleakage was observed in A3b and A3a, whereas B4b and B4a were the subgroups with the highest microleakage. Following saliva contamination, when surface conditioning was not re-applied, the effects of fissure sealant types and surface conditioning were significant (p=0.005 and p Conclusions: 3M Clinpro™ Sealant was superior to Ultraseal XT Hydro. Re-application of Er,Cr:YSSG laser and the self-etching adhesive did not affect the microleakage of both fissure sealants. Without re-application, acid-etching+etch-and-rinse adhesive was superior to acid-etching only. However, both of them were similarly successful when they were re-applied following saliva contamination

Non-relativistic ten-dimensional minimal supergravity

We construct a non-relativistic limit of ten-dimensional N=1 supergravity from the point of view of the symmetries, the action, and the equations of motion. This limit can only be realized in a supersymmetric way provided we impose by hand a set of geometric constraints, invariant under all the symmetries of the non-relativistic theory, that define a so-called `self-dual' Dilatation-invariant String Newton-Cartan geometry. The non-relativistic action exhibits three emerging symmetries: one local scale symmetry and two local conformal supersymmetries. Due to these emerging symmetries the Poisson equation for the Newton potential and two partner fermionic equations do not follow from a variation of the non-relativistic action but, instead, are obtained by a supersymmetry variation of the other equations of motion that do follow from a variation of the non-relativistic action. We shortly discuss the inclusion of the Yang-Mills sector that would lead to a non-relativistic heterotic supergravity action.Comment: 40 pages, minor change

Current clinician perspective on non-vitamin K antagonist oral anticoagulant use in challenging clinical cases.

OBJECTIVE: The evolution of non-vitamin K antagonist anticoagulants (NOACs) has changed the horizon of stroke prevention in atrial fibrillation (SPAF). All 4 NOACs have been tested against dose-adjusted warfarin in well-designed, pivotal, phase III, randomized, controlled trials (RCTs) and were approved by regulatory authorities for an SPAF indication. However, as traditional RCTs, these trials have important weaknesses, largely related to their complex structure and patient participation, which was limited by strict inclusion and extensive exclusion criteria. In the real world, however, clinicians are often faced with complex, multimorbid patients who are underrepresented in these RCTs. This article is based on a meeting report authored by 12 scientists studying atrial fibrillation (AF) in diverse ways who discussed the management of challenging AF cases that are underrepresented in pivotal NOAC trials. METHODS: An advisory board panel was convened to confer on management strategies for challenging AF cases. The article is derived from a summary of case presentations and the collaborative discussions at the meeting. CONCLUSION: This expert consensus of cardiologists aimed to define management strategies for challenging cases with patients who underrepresented in pivotal trials using case examples from their routine practice. Although strong evidence is lacking, exploratory subgroup analysis of phase III pivotal trials partially informs the management of these patients. Clinical trials with higher external validity are needed to clarify areas of uncertainty. The lack of clear evidence about complex AF cases has pushed clinicians to manage patients based on clinical experience, including rare situations of off-label prescriptions

A search on the Nikiforov-Uvarov formalism

An alternative treatment is proposed for the calculations carried out within the frame of Nikiforov-Uvarov method, which removes a drawback in the original theory and by pass some difficulties in solving the Schrodinger equation. The present procedure is illustrated with the example of orthogonal polynomials. The relativistic extension of the formalism is discussed.Comment: 10 page

An integrated assessment of water quality in an arsenic containing aquifer: Milestones from hydrogeology to public health

5th International Perspective on Water Resources & the Environment Conference (IPWE 2012), MoroccoA multi-disciplinary research is being conducted in Simav Plain, Turkey where an arsenic containing aquifer is at the center of attention. The study is not only aimed to understand the sources and mechanisms of the presence of high arsenic levels in groundwater but also to determine the associated consequences with regards to human health. The high arsenic levels in most groundwater (N=33, avg. 162 ppb), surface water (N=9, avg. 76.6 ppb) and geothermal water (N=3, avg. 406 ppb) samples are strongly related to high occurrences of arsenic in rocks and soils of the plain, which range between 7.1 and 833.9 ppm with an average of 49 ppm. These values correspond to several orders of magnitude higher than international standards and world averages in water and soil, respectively. With this motivation, this research also focuses on human health in the study area associated with exposure to these high arsenic levels via numerous pathways. Consequently, more than 1000 individuals were personally surveyed by public health specialists to determine an inventory of diseases in the area. Furthermore, a verbal autopsy study was also conducted with relatives of the deceased, which were further verified with hospital records, to understand the underlying death cause. As a result, certain cancer rates were found to exceed national averages and the results statistically demonstrated a potential link with high arsenic levels mainly through oral exposure

Exponential Type Complex and non-Hermitian Potentials in PT-Symmetric Quantum Mechanics

Using the NU method [A.F.Nikiforov, V.B.Uvarov, Special Functions of Mathematical Physics, Birkhauser,Basel,1988], we investigated the real eigenvalues of the complex and/or $PT$- symmetric, non-Hermitian and the exponential type systems, such as Poschl-Teller and Morse potentials.Comment: 14 pages, Late