An ethnobotanical analysis on wild edible plants of the turkish asteraceae taxa

Asteraceae (Compositae) is one of the biggest families in the Flora of Turkey as in the World. Also, it is one of the most important families in which many popular plants are used as food and recreational tea in Turkey. The aim of this study is to make an ethnobotanical analysis on the wild edible plants of the Asteraceae family in Turkey, according to our investigations and scientific literature records. This study is based on local ethnobotanical investigations. The information about the plants was obtained from the local people through open and semi-structured interviews. In the light of our investigations and the literature records, 43 genera (including 121 taxa) of Asteraceae (used for food, tea and other purposes) were determined. Among them, Scorzonera, Tragopogon, Cirsium, Centaurea, Onopordum, Taraxacum, Echinops, Achillea, Anthemis and Carduus are the most popular genera in the localities of Turkey

Synthesis, and prediction of molecular properties and antimicrobial activity of some acylhydrazones derived from N-(arylsulfonyl)methionine

Sellitepe, Hasan Erdinc/0000-0001-5339-6940; Pannecouque, Christophe/0000-0002-1254-4473; Tatar, Esra/0000-0003-3490-8597; Kucukguzel, Ilkay/0000-0002-7188-1859; senkardes, sevil/0000-0002-0523-459X; BOZDEVECI, ARIF/0000-0002-0729-9143WOS: 000376305300013A series of 38 new acylhydrazones [3-40], derived from (2S)-4-(methylsulfanyl)-2-[[(4-methylphenyl)sulfonyl] amino]butanoic acid hydrazide [2], were synthesized and evaluated for their anti-HIV and antimicrobial activity with the further aim to develop acylhydrazones carrying an amino acid side chain. All tested compounds possess stronger activity against gram (+) bacteria. Compound 23 was found active against methicillin-resistant Staphylococcus aureus (MRSA) with a MIC value of 3.9 mu g/mL. the MIC value of compound 30 against Enterococcus faecalis, Listeria monocytogenes, and Bacillus cereus was 8 mu g/mL. A computational study for prediction of ADME and drug-like properties (solubility, drug-likeness, and drug score) as well as potential toxicity profiles of compounds 2-40 was performed using the Molinspiration online property calculation toolkit and Osiris Property Explorer. As most of our compounds meet Lipinski's rule of five, they promise good solubility and permeability. According to Osiris calculations, the majority of our compounds are supposed to be nonmutagenic and nonirritating.Research Fund of Marmara UniversityMarmara University [SAG-A-060510-0109]This work was supported by the Research Fund of Marmara University, project number: SAG-A-060510-0109