Relative bioavailability study of a generic effervescent tablet formulation of dexketoprofen and thiocolchicoside versus the originator 25 mg film coated tablet (dexketoprofen) and 8 mg capsule (thiocolchicoside)

Aims: The aim of this study was to evaluate the pharmacokinetic profiles and the relative bioavailability of dexketoprofen and thiocolchicoside of the test preparation (dexketoprofen / thiocolchicoside 25 mg / 8 mg effervescent tablet) in comparison with the reference preparations (Keral 25 mg film coated tablet, containing dexketoprofen trometamol equivalent to 25 mg dexketoprofen (Menarini International Operations Luxembourg S.A.) (R1) and Muscoril 8 mg capsule, containing 8 mg thiocolchicoside (Sanofi Aventis İlaçları Ltd. Şti.) (R2) under fasting conditions. Methods: 25 healthy male subjects were enrolled in the study. Volunteers were hospitalised from the evening before drug administration (Day 0) until after the 24-hour blood sampling time on Day 2. Results: 24 subjects completed the study. Relative bioavailability (AUCT/AUCR1) of dexketoprofen from the test preparation was 100.99 %; (AUCT/AUCR2) of 3-O-glucuronide of thiocolchicoside (aglycone) from the test preparation was 100.47 %; (Cmax,T/Cmax,R1) of dexketoprofen from the test preparation was 122.59 %; (Cmax,T/Cmax,R2) of 3-O-glucuronide of thiocolchicoside (aglycone) from the test preparation was 111.43 %. Conclusions: The relative bioavailability AUCT /AUCR of the test preparation compared with both reference preparations is comparable, as shown by the geometric mean ratios of 100.59 % (dexketoprofen) and of 98.20 % (3-O-glucuronide of thiocolchicoside (aglycone)

Understanding public speakers’ performance: first contributions to support a computational approach

Communication is part of our everyday life and our ability to communicate can have a significant role in a variety of contexts in our personal, academic, and professional lives. For long, the characterization of what is a good communicator has been subject to research and debate by several areas, particularly in Education, with a focus on improving the performance of teachers. In this context, the literature suggests that the ability to communicate is not only defined by the verbal component, but also by a plethora of non-verbal contributions providing redundant or complementary information, and, sometimes, being the message itself. However, even though we can recognize a good or bad communicator, objectively, little is known about what aspects – and to what extent—define the quality of a presentation. The goal of this work is to create the grounds to support the study of the defining characteristics of a good communicator in a more systematic and objective form. To this end, we conceptualize and provide a first prototype for a computational approach to characterize the different elements that are involved in communication, from audiovisual data, illustrating the outcomes and applicability of the proposed methods on a video database of public speakers.publishe

Voice Traces of Anxiety : Acoustic Parameters Affected by Anxiety Disorder

Although the emotions and learning based on emotional reaction are individual-specific, the main features are consistent among all people. Depending on the emotional states of the persons, various physical and physiological changes can be observed in pulse and breathing, blood flow velocity, hormonal balance, sound properties, face expression and hand movements. The diversity, size and grade of these changes are shaped by different emotional states. Acoustic analysis, which is an objective evaluation method, is used to determine the emotional state of people’s voice characteristics. In this study, the reflection of anxiety disorder in people’s voices was investigated through acoustic parameters. The study is a case-control study in cross-sectional quality. Voice recordings were obtained from healthy people and patients. With acoustic analysis, 122 acoustic parameters were obtained from these voice recordings. The relation of these parameters to anxious state was investigated statistically. According to the results obtained, 42 acoustic parameters are variable in the anxious state. In the anxious state, the subglottic pressure increases and the vocalization of the vowels decreases. The MFCC parameter, which changes in the anxious state, indicates that people can perceive this situation while listening to the speech. It has also been shown that text reading is also effective in triggering the emotions. These findings show that there is a change in the voice in the anxious state and that the acoustic parameters are influenced by the anxious state. For this reason, acoustic analysis can be used as an expert decision support system for the diagnosis of anxiety