Clinical Efficacy of Low Dose Flutamide plus Diane-35 in the Treatment of Idiopathic Hirsutism and Polycystic Ovary Syndrome

Objective: Idiopathic hirsutism (IH) or polycystic ovary syndrome (PCOS) are the most common causes of hirsutism which affects 5–10 % of all women. The aim of this study was to evaluate the efficacy of flutamide plus diane 35 in the treatment of idiopathic hirsutism and polycystic ovary syndrome. Materials and Methods: 26 polycystic ovary syndrome and 24 idiopathic hirsutism patients were evaluated. Fifty patients were divided into two groups according to their diagnosis: idiopathic hirsutism or polycystic ovary syndrome. All patients received 125mg Flutamide once a day and Diane 35 tablets for 21 days of each month, for 12 months. We measured hirsutism scores and hormonal levels of all patients. Evaluations were done before treatment, in the 6th and 12th months of therapy. Results: There were no significant differences in Ferriman-Gallwey scores at the beginning and at the end of the therapy between the IH and PCOS groups. The decreases in Ferriman-Gallwey scores were significant in both groups in the 6th and 12th month of therapy. Combined treatment significantly decreased total and free testosterone, DHEAS and significantly increased SHBG levels in both groups and additionally decreased levels of LH, androstenodione and LH/FSH ratio in the polycystic ovary syndrome group. Conclusion: Combined treatment was effective and safe in the treatment of hirsutism. Combined regimens have additional effects on the treatment of hirsutism

he assessment of the perinatal outcomes of the patients who underwent quad screening test

Objective The aim of this study is to assess the correlation between the poor perinatal outcomes and the serum biochemical markers such as maternal serum alpha fetoprotein (AFP), human chorionic gonadotropin (hCG), unconjugated estriol (uE3) and inhibin-A (INH-A) checked during the quad screening test. Methods In this retrospective study, the results of 485 pregnant women who underwent quad screening test in the Outpatient Clinic of Gynecology and Obstetrics of Faculty of Medicine at Erciyes University, Kayseri, Turkey between January 2018 and January 2019 and met the inclusion criteria were analyzed. The primary result of the study was established as the development of poor perinatal outcomes. The poor perinatal outcomes were defined as gestational diabetes (GDM), gestational hypertension (GHT), preeclampsia, intrauterine growth restriction (IUGR), preterm labor, premature rupture of membranes (PRM), oligohydramnios, polyhydramnios, HELLP syndrome, and intrahepatic cholestasis of pregnancy (ICP). Results A total of 485 pregnant women, who met the inclusion criteria, were included in the study. A significant correlation was found between AFP MoM≥2 and GHT, PRM, preterm labor, and the development of IUGR (p=0.017, p=0.033, p=0.037, and p=0.038, respectively). It was seen that the risk increased 5.1 times for GHT, 3.2 times for preterm labor, and 3.8 times for the development of IUGR. There was a significant correlation between hCG MoM≥2 and the risk of GHT development (p=0.024); however, the risk of GHT development increased for 3.8 times above this value. A significant correlation was found between INH-A being MoM≥2 and the development of GHT and HELLP syndrome (p=0.009 and p=0.005, respectively). In these pregnant women, the risk increased 31 times for the development of HELLP syndrome, and 9.4 times for GHT. In the cases with uE3 MoM£0.5, there was a significant correlation for the development of preeclampsia and HELLP syndrome (p=0.033 and p=0.049, respectively). On the other hand, there was no significant correlation between GDM, ICP, polyhydramnios, and oligohydramnios and AFP MoM, beta-hCG MoM, uE3 MoM and INH-A MoM values. Conclusion In our study, we found correlation between poor perinatal outcomes and the changes in AFP, hCG, uE3 and INH-A levels

Investigation of premenstrular dysphoric disorder comorbidity and related factors in patients with anxiety disorder

Abstract Aim: Because of the fact that the frequency of both anxiety disorders and premenstrual dysphoric disorder (PMDD) are high in women and that studies investigating PMDD comorbidity in patients diagnosed with anxiety disorder are limited, this study was aimed to investigate PMDD comorbidity and related factors in patients with anxiety disorders. Materials and Methods: 183 subjects who were followed up with a diagnosis of anxiety disorder in Necmettin Erbakan University Meram Medical Faculty Psychiatry Outpatient Clinic were included in the study and were evaluated with Sociodemographic Data Form, Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI). PMDD comorbidity was investigated according to The Diagnostic and Statistical Manual of Mental Disorders fourth edition (DSM-IV-TR) criteria by making psychiatric interviews. Results: 57 (31.2%) of 183 subjects diagnosed with PMDD constituted the PMDD group and the remaining 126 patients constituted the non-PMDD group. The mean BAI scores of the PMDD group were significantly higher than those of the non PMDD group, whereas the mean age of the PMDD group was significantly lower than that of the non PMDD group. The BMI of the PMDD group was significantly higher than that of the non PMDD group. Conclusion: PMDD is common in patients followed up with a diagnosis of anxiety disorder and what is associated with PMDD is be young age as well as excessive chocolate consumption.</div