ほんの少し未来の図書館とは？

Articledepartmental bulletin pape

A Japanese Translation of the Dam pa'i chos puṇḍa rī ka'i ' grel pa: Chapter X

departmental bulletin pape

プロンプト作成の負荷を軽減する生成系AIを用いた学習支援ツールの提案

conference pape

Effects of Liquid Film Formed on Flask Surface on Oxygen Transfer Rate in Shaking Flask and Development of Baffled Shaking Vessel by Optical Method Based on Sulfite Oxidation

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必修科目としてメンタルヘルス教育を実施することの意味(1)-大学生の現状と課題-

text紀要論文 / Departmental Bulletin Paperdepartmental bulletin pape

19F chemical library and 19F-NMR for a weakly bound complex structure

Fragment-based drug discovery (FBDD), which involves small compounds <300 Da, has been recognized as one of the most powerful tools for drug discovery. In FBDD, the affinity of hit compounds tends to be low, and the analysis of protein-compound interactions becomes difficult. In an effort to overcome such difficulty, we developed a F-19-NMR screening method optimizing a F-19 chemical library focusing on highly soluble monomeric molecules. Our method was successfully applied to four proteins, including protein kinases and a membrane protein. For FKBP12, hit compounds were carefully validated by protein thermal shift analysis, H-1-N-15 HSQC NMR spectroscopy, and isothermal titration calorimetry to determine dissociation constants and model complex structures. It should be noted that the H-1 and F-19 saturation transfer difference experiments were crucial to obtaining highly precise model structures. The combination of F-19-NMR analysis and the optimized F-19 chemical library enables the modeling of the complex structure made up of a weak binder and its target protein.journal articl

Is the risk of small-for-gestational-age influenced by maternal body composition in young Japanese women?

journal articl

Observation of B+→Ξ̅c0Λc+ and evidence for B0→Ξ̅c-Λc+

journal articl

横浜国立大学教育人間科学部鎌倉小学校における教員養成への取り組み

departmental bulletin pape

Circuit model representing transient characteristics of transformer and TRV simulation

departmental bulletin pape