10 過去2年間にoccipital transtentorial approachを用いて手術を行った症例の検討(北日本脳神経外科連合会第28回学術集会)

departmental bulletin pape

第一次世界大戦期における軍隊と地域社会 ： 佐賀歩兵第五五連隊の青島出征を事例に

論文(Article)departmental bulletin pape

日本法教育研究センターで学ぶ学生たちのライティングをどう評価するか ： 法学講師の評価プロトコルから見えてくるもの

2016-06-01This research paper aims to shed further light on the education methods which are used while assessing the Japanese language writing skills of foreign students enrolled in the Research and Education Center for Japanese Law (CJL). The present study is based on qualitative analysis of how two law lecturers with different backgrounds (one, a researcher with a theory based background, and the other a practicing lawyer) rated short essay responses for the Examination for Japanese University Admission for International Students by three Cambodian students who had studied in CJL for one and a half years. The law lecturers were firstly asked to conduct an assessment of the essays while thinking out loud. After this evaluation had been carried out, a stimulated recall method was used in combination with a semi-structured interview and the speech protocols were collected. The speech protocols were analyzed though the Steps for Coding and Theorization (SCAT) approach. The results were coded into seven common categories: relative evaluation, conscious division of labor based on difference of expertise, suitability of written response, importance of structure, logical consistency, authenticity of information, and self-meta-assessment. Through this experimental study, it has been possible to gain some insight from an analysis of the story lines and theoretical description of what is sought from a Japanese language instructor when working with law lecturers.departmental bulletin pape

Additional file 1: of Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency

Figure S1. Measurement of Glycosylated HexA and GCase by Western Blot. The western blots in fig. 3 measured the glycosylated forms of HexA and GCase, which was confirmed by loss of these bands after digestion with the glycosidase PNGase F. The glycosylated forms of HexA and GCase are labeled with black arrows, the unglycosylated forms with gray arrows, and nonspecific bands with asterisks. (DOCX 195 kb

Additional file 1: of Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease

Figure S1. Semiquantitative assessment of neurodegeneration. Grading neurodegeneration in FCtx, hippocampal DF, CA4 and CA2/3 are shown. In FCtx, neurodegeneration was assessed by superficial microvacuolation and spongiosis. In DF, gaps in granular cell density were assessed as neurodegeneration. In CA4 and CA2/3, neuronal cell loss and gliosis were assessed as neurodegeneration. Neurodegeneration was graded as absent (G0), mild (G1), moderate (G2) or severe (G3). (TIF 1630 kb

Additional file 4: of Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease

Figure S3. Dot plot graph of semiquantitative assessment of neurodegeneration and DPR. Note that X axis is neurodegeneration score (0 to 3), Y-axis is density of DPR. FCtx - frontal cortex, DF - dentate fascia, CA4 - cornu ammonis sector 4. (TIF 1325 kb

Additional file 7: of Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease

Figure S5 Comparison of immunostaining with aDMA between C9ORF72 cases and non- neurodegeneration control in parahippocampal cortex. The nuclear signal of aDMA is variable in both cases and controls. Note sparse cytoplasmic inclusions labeled with aDMA in in C9ORF72 cases (arrows). Scale bar represents 50 ΟM. (TIF 2898 kb

Additional file 5: of Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease

Figure S4. Western blot analysis of aDMA and sDMA in brains of C9FLTD-MND and sporadic FTLD-MND. The high molecular weight aDMA and sDMA signals are visible in c9FTD/ALS, but not in sporadic FTD/ALS cases. (TIF 2960 kb

Additional file 2: of Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease

Figure S2. Correlation between manual counts and positive pixel burden from color deconvolution in poly-GR staining. Plot shows the correlation of manual counts of neuronal cytoplasmic inclusions and positive pixel burden from color deconvolution in poly-GR staining. The line shows linear regression CD color deconvolution. Ctx frontal cortex, DF dentate fascia, CA - cornu ammonis, MCtx motor cortex. (TIF 2581 kb

Additional file 3: of Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease

Table S1. Quantitative assessment of DPR density by color deconvolution algorithm in clinicopathologic subgroups of C9ORF72-related disease. In frontal cortex, p = 0.019, FTLD vs. FTLD-MND. In CA4, p = 0.055, FTLD vs. FTLD-MND. In CA2/3, p = 0.03, FTLD vs. FTLD-MND. Significant p-values (< 0.05) are indicated in bold. All variables were analyzed with Kruskal-Wallis ANOVA on Ranks and data are displayed as median (25th and 75th range). *Statistically significant p-value (p < 0.05); all p-value for ANOVA on Ranks comparison of all three groups. FCtx = frontal cortex, MCtx = Motor cortex, DF dentate fascia, CA hippocampal subfields. (DOCX 15 kb