Theory of Josephson effect in chiral p-wave superconductor / diffusive normal metal / chiral p-wave superconductor junctions

We study the Josephson effect between chiral p-wave superconductor / diffusive normal metal (DN) / chiral p-wave superconductor (CP/DN/CP) junctions using quasiclassical Green's function formalism with proper boundary conditions. The px+ipy-wave symmetry of superconducting order parameter is chosen which is believed to be a pairing state in Sr2RuO4. It is shown that the Cooper pairs induced in DN have an odd-frequency spin-triplet s-wave symmetry, where pair amplitude is an odd function of Matsubara frequency. Despite the peculiar symmetry properties of the Cooper pairs, the behavior of the Josephson current is rather conventional. We have found that the current phase relation is almost sinusoidal and the Josephson current is proportional to exp(-L/xi), where xi is the coherence length of the Cooper pair in DN and L is the length of DN. The Josephson current between CP / diffusive ferromagnet metal (DF) / CP junctions is also calculated. It is shown that the 0-pi transition can be realized by varying temperature or junction length L similar to the case of conventional s-wave junctions. These results may serve as a guide to study superconducting state of Sr2RuO4.Comment: 9 pages, 9 figure

Quasiclassical Green's function theory of the Josephson effect in chiral ρ-wave superconductor/diffusive normal metal/chiral ρ-wave superconductor junctions

We study the Josephson effect in chiral p-wave superconductor/diffusive normal metal (DN)/chiral p-wave superconductor (CP/DN/CP) junctions using quasiclassical Green’s function formalism with proper boundary conditions. The px+ipy-wave symmetry of superconducting order parameter is chosen which is believed to be the pairing state in Sr2RuO4. We show that the superconducting pair amplitude induced in DN has an oddfrequency spin-triplet s-wave symmetry and is an odd function of Matsubara frequency. Despite the peculiar symmetry properties of the Cooper pairs, the behavior of the Josephson current is rather conventional. We have found that the current-phase relation is almost sinusoidal and the Josephson current is proportional to exp(−L/ξ), where ξ is the coherence length in DN and L is the thickness of the DN layer. We also calculate the Josephson current in CP/diffusive ferromagnet metal/CP junctions and show that the 0-π transition can be realized by varying temperature or thickness L similar to the case of conventional s-wave junctions. The obtained results may help to explore the properties of superconducting state in Sr2RuO4.journal articl

A square-planar Ni(II) complex with an N2S2 donor set similar to the active centre of nickel-containing superoxide dismutase and its reaction with superoxide

The structure around the metal centre of a Ni(ii) complex with an N 2S2 square-planar geometry, 1, prepared as a model compound of the NiSOD active site was drastically changed upon addition of potassium superoxide (KO2).application/pdfjournal articl

若年女子学生の食生活の実態と健康状態について

P(論文)http://www.tsc-05.ac.jp/pdf_library/2008.pdfdepartmental bulletin pape

Measurement of the Lepton Mass and an Upper Limit on the Mass Difference between + and -

journal articl

Table_1_Association Between Menstrual Patterns and Adverse Pregnancy Outcomes in Patients With Polycystic Ovary Syndrome.docx

ObjectiveTo investigate the results of in vitro fertilization among polycystic ovary syndrome (PCOS) patients using the long-acting long protocol regarding the relationship between menstrual patterns and adverse pregnancy outcomes.DesignRetrospective cohort study.SettingUniversity-affiliated reproductive medical center.BackgroundThe menstrual patterns of patients with PCOS is considered related to metabolism; however, no study has analyzed the outcome of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) in patients with PCOS who have different menstrual patterns. This study aimed to observe the outcomes of IVF/ICSI in patients with PCOS with different menstrual patterns who used the long-acting long protocol.MethodsThis was a retrospective analysis in the first cycle of IVF/ICSI at the Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University from January 2017 to December 2019. In total, 1834 patients with PCOS were classified into the regular menstruation group (n=214), the oligomenorrhea group (n=1402), and the amenorrhea group (n=218).ResultsPCOS patients who used the long-acting long protocol of IVF/ICSI had similar clinical pregnancy rates and live birth rates despite having different menstrual patterns. The overall incidence of adverse pregnancy outcomes, including abortion, spontaneous preterm birth (sPTB), gestational diabetes(GDM), hypertensive disorder inpregnancy (HDP), and premature rupture of membranes(PROM, was significantly higher in the amenorrhea group than in the regular menstrual and oligomenorrhea groups (25.88% vs. 30.41% vs. 43.69%; P = 0.013). Additionally, the rates of GDM (2.35% vs. 6.10% vs. 13.79%; P=0.015) and macrosomia (5.26% vs. 10.94% vs. 18.39%; P=0.026) in the amenorrhea group were significantly higher than those in the other two groups. Correction for confounding factors showed that menstrual patterns are related to the occurrence of adverse pregnancy outcomes. Amenorrhea is an independent risk factor for adverse pregnancy outcome (OR [odds ratio]: 2.039, 95% CI [confidence interval]: 1.087-3.822), GDM (OR: 5.023, 95% CI: 1.083–23.289), and macrosomia (OR: 4.918, 95% CI: 1.516–15.954).ConclusionsIVF/ICSI can achieve similar pregnancy and live birth rates in PCOS patients with different menstrual patterns. However, the overall incidence of adverse pregnancy outcomes in PCOS patients with amenorrhea is higher than that in patients with regular menstruation or oligomenorrhea.</p

Additional file 1 of Increased expression of prokineticin 2 and its receptor in endometrium of recurrent implantation failure patients decreased the expression of MMP9 important for decidualization

Additional file 1. Supplementary material-PCR. Original RT-qPCR data

Additional file 1 of Is early-follicular long-acting GnRH agonist protocol an alternative for patients with polycystic ovary syndrome undergoing in vitro fertilization?

Additional file 1: Supplementary Table 1. Univariate logistic regression performed for GDM. Supplementary Figure 1. Forest plot: multivariate logistic regression performed for GDM

Effect of elevated progesterone levels the day before ovulation on pregnancy outcomes in natural cycles of frozen thawed embryo transfer

We aimed to analyze whether elevated progesterone levels on the day before ovulation affected pregnancy outcomes in natural cycles of frozen thawed embryo transfer (NC-FET). A retrospective analysis was conducted in a public university hospital. Data on clinical pregnancy, live birth, ectopic pregnancy, and miscarriage rates were collected, along with other patient data. Patients were divided into two groups according to their progesterone levels the day before ovulation: the progesterone elevation (PE) group (progesterone level >1.0 ng/mL) and the normal progesterone (NP) group (progesterone level ≤1.0 ng/mL). We assessed the effect of elevated progesterone levels in NC-FET by performing multivariate logistic regression analysis. Overall 1159 women with tubal factor infertility who underwent NC-FET were enrolled, including 666 women who received cleavage-stage embryo transfers and 493 women who received blastocyst embryo transfers. When two cleavage-stage embryos were transferred, the clinical pregnancy rate was significantly higher in the PE than in the NP group following NC-FET (p  .05). After correcting for various confounders, we found that elevated progesterone levels (adjusted odds ratio [OR]: 1.672; 95% confidence interval [CI]: 1.089–2.566, p = .018) improved the clinical pregnancy rate following transfer of two cleavage-stage embryos but did not affect the pregnancy rate when blastocyst-stage embryos were transferred (adjusted OR: 0.856; 95% CI: 0.536–1.369; p = .517). The results showed that in patients undergoing cleavage-stage NC-FET, progesterone levels >1.0 ng/mL improved the clinical pregnancy rates. However, the level of progesterone had no effect on the clinical pregnancy rate for patients undergoing blastocyst-stage NC-FET.</p

小児癌細胞における細胞死誘導耐性化機序の解明とその克服手段の開発

application/pdf抗Fas抗体刺激によりアポトーシス細胞死が誘導される白血病細胞株を用いて、カスパーゼ-8、カスパーゼ-3の活性化がどの細胞周期において誘導されるかを明らかにした。その結果、カスパーゼ-8の活性化は、G0/G1期において、カスパーゼ-3の活性化は、G0/G1期からearly S期にかけて誘導されることが示唆された(平成17年度実績)。今年度においては、抗Fas抗体刺激によりカスパーゼ-3の活性化された細胞をセルソーティングにより分離し、細胞周期調節蛋白の発現を検討したところ、サイクリンE、サイクリンD1陽性、サイクリンA、サイクリンB1、p27/kip-1、Ki67陰性であり、カスパーゼー3の活性化は、G1後期からearly S期にかけて誘導されていることが確認された。 また、細胞増殖/生存に重要なPI3 Kinase/Akt経路の活性と細胞死受容体を介した細胞死誘導の関連を検索した。TRAIL (Tumor necrosis factor-related apoptosis-inducing ligand)刺激による細胞死誘導に対して耐性を獲得した細胞においては、Aktのリン酸化が誘導されており、PI3 Kinase/Akt経路が活性化されていた。耐性細胞をPI3 Kinase阻害剤で前処理することにより、TRAILによる細胞死誘導が見られるようになり、PI3 Kinase/Akt経路の活性化が細胞死誘導の耐性化に関与していると考えられた。また、Aktのリン酸化の元進の機序に関しては、2つのフォスプァターゼ(PTEN/phosphate and tensin homologue deleted on chromosome 10、PHLLP/PH domain leucine-rich repeat protein phosphatase)の発現を解析した。PHLLPの発現は、感受性細胞と耐性細胞の間に差は認められなかった。PTENも感受性細胞と耐性細胞ともに同程度の発現を認めたが、リン酸化(不活性化)PTENの発現は、耐性細胞において著しく増加していた。すなわち、耐性細胞におけるAktのリン酸化 (活性化)の亢進は、Aktの活性化を抑制するPTENのリン酸化亢進による不活性化によることが示唆された。 次年度においては、細胞回転を阻害することにより、細胞死受容体を介する刺激によるカスパーゼの活性化が抑制され、その結果として細胞死の誘導が障害されるかを検討する予定である。また、PI3 Kinase/Akt経路と並んで細胞増殖/生存に重要なMEK/MAPK経路に関しても検討を加える予定である。平成17〜19年度科学研究費補助金(基盤研究(B)(2))研究成果報告書津6217390301research repor