Self-induced structure in the current-voltage characteristics of RSQUIDs

Resistive two-junction SQUIDs (RSQUIDs) made from high-temperature superconductors are being developed as narrow-linewidth tunable oscillators in the GHz frequency range. We present here the results of numerical simulation of RSQUIDs of this type. These studies have identified conditions where sub-harmonic steps and other features are apparent in the current-voltage characteristics, driven by the internally-generated heterodyne frequency. The behavior is sensitive to the frequency (set by the voltage across the resistive element in the RSQUID), the temperature and also the loop inductance. We have studied the effects of thermal noise on these features. We also assess how these effects might be observed, and consider how they might affect practical applications of high frequency heterodyne RSQUID oscillators

On the use of the type I Gumbel distribution to assess risks given floods

In this article, there is considered the possibility of using the type I Gumbel distribution as one among alternative forecasting models in assessing flood risks at rivers, which is carried out based on forecasting of maximum hydrological characteristics according to hydrological observations. Examples are given and analyzed are the results of forecasting of the maximum water discharges of low exceedance probabilities, which were obtained with the use of the type I Gumbel distribution and other probability distributions for the Dnieper (the Vyshgorod water level gauge) and the Stryi River (the Verkhnye Syn’ovydne water level gauge). In addition to the analytical distributions for the Dnieper River, a generalized probability distribution function obtained by modeling within the fuzzy set theory was also used in the comparative analysis. The possibility of extending the scope of the practical application of the type I Gumbel distribution in forecasting hydrological maxima by logarithmic transformation is shownРозглядається можливість використання розподілу Гумбеля типу І в якості однієї з альтернативних прогнозних моделей при оцінці ризиків повеней на ріках, що здійснюється на основі прогнозування максимальних гідрологічних характеристик за даними гідрологічних спостережень. Наведено приклади та проаналізовано результати прогнозування максимальних витрат води малої ймовірності перевищення, отримані з використанням розподілу Гумбеля типу І та альтернативних розподілів ймовірності, для Дніпра (гідрометричний пост Вишгород) та Стрия (Верхнє Синьовидне). Окрім аналітичних розподілів, для ріки Дніпра при порівняльному аналізі також використовувалась узагальнена функція розподілу ймовірності, отримана моделюванням в межах теорії нечітких множин. Показано можливість розширення сфери практичного застосування розподілу Гумбеля типу І при прогнозуванні гідрологічних максимумів за рахунок логарифмічного перетворення.Рассматривается возможность использования распределения Гумбеля типа І в качестве одной из альтернативных прогнозных моделей при оценке рисков наводнений на реках, осуществляемой на основе прогнозирования максимальных гидрологических характеристик по данным гидрологических наблюдений. Приведены примеры и проанализированы результаты прогнозирования максимальных расходов воды малой вероятности превышения, полученные с использованием распределения Гумбеля типа І и альтернативных распределений вероятности, для Днепра (гидрометрический пост Вышгород) и реки Стрый (Верхнее Синевидное). Кроме аналитических распределений , для реки Днепр при сравнительном анализе также использовалась обобщенная функция распределения вероятности, полученная моделированием в рамках теории нечетких множеств. Показана возможность расширения сферы практического применения распределения Гумбеля типа І при прогнозировании гидрологических максимумов за счет логарифмического преобразования

There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer

Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal length and stability thus leading to cellular immortalisation. The hTERT (human telomerase reverse transcriptase) subunit seems to be the rate-limiting determinant of telomerase and knowledge of factors controlling hTERT transcription may be useful in therapeutic strategies. The hTERT promoter contains binding sites for c-Myc and there is experimental and in vitro evidence that c-Myc may increase hTERT expression. Materials and methods RNA was extracted from 18 breast carcinomas and c-Myc mRNA expression was estimated by quantitative reverse transcriptase-PCR (RT-PCR) with Taqman methodology. These tumours had already been analysed for ER and PgR status using ligand-binding assays and had had their DNA ploidy and S-phase fractions measured by flow cytometry. Telomerase activity had already been determined by using a modified telomeric repeat and amplification protocol (TRAP) assay. Results Telomerase activity ranged from 0 to 246 units of Total Protein Generated (TPG), where one unit of TPG was equal to 600 molecules of telomerase substrate primers extended by at least three telomeric repeats. Median levels of TPG were 60 and mean levels 81. There was no significant correlation between levels of c-Myc mRNA expression, telomerase activity, S phase fraction or PgR. There was a significant negative correlation with ER status. Conclusion Although the hTERT promoter contains potential binding sites for c-Myc oncoprotein, we have found no correlation between c-Myc mRNA levels and telomerase activity

William (Bill) Peterson's contributions to ocean science, management, and policy

© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Schwing, F. B., Sissenwine, M. J., Batchelder, H., Dam, H. G., Gomez-Gutierrez, J., Keister, J. E., Liu, H., & Peterson, J. O. William (Bill) Peterson's contributions to ocean science, management, and policy. Progress in Oceanography, 182, (2020): 102241, doi:10.1016/j.pocean.2019.102241.In addition to being an esteemed marine ecologist and oceanographer, William T. (Bill) Peterson was a dedicated public servant, a leader in the ocean science community, and a mentor to a generation of scientists. Bill recognized the importance of applied science and the need for integrated “big science” programs to advance our understanding of ecosystems and to guide their management. As the first US GLOBEC program manager, he was pivotal in transitioning the concept of understanding how climate change impacts marine ecosystems to an operational national research program. The scientific insight and knowledge generated by US GLOBEC informed and advanced the ecosystem-based management approaches now being implemented for fishery management in the US. Bill held significant leadership roles in numerous international efforts to understand global and regional ecological processes, and organized and chaired a number of influential scientific conferences and their proceedings. He was passionate about working with and training young researchers. Bill’s academic affiliations, notably at Stony Brook and Oregon State Universities, enabled him to advise, train, and mentor a host of students, post-doctoral researchers, and laboratory technicians. Under his collegial guidance they became critical independent thinkers and diligent investigators. His former students and colleagues carry on Bill Peterson’s legacy of research that helps us understand marine ecosystems and informs more effective resource stewardship and conservation

The Stochastic Aspects of Long-Term Water Resources Planning as Applied to the Integrated Regional Development Problem

Water resources systems have been an important part of resources and environment related research at IIASA since its inception. As demands for water increase relative to supply, the intensity and efficiency of water resources management must be developed further. This in turn requires an increase in the degree of detail and sophistication of the analysis, including economic, social and environmental evaluation of water resources development alternatives aided by application of mathematical modeling techniques, to generate inputs for planning, design, and operational decisions. During the year of 1978 it was decided that parallel to the continuation of demand studies, an attempt would be made to integrate the results of our studies on water demands with water supply considerations. This new task was named "Regional Water Management" (Task 1, Resources and Environment Area). It is concerned with the application of systems analysis techniques for planning and operational management of integrated regional water resources systems. This paper by Dr. S. Velikanov from the Institute of Water Problems of the USSR Academy of Sciences was drafted during his short visit to IIASA in early 1978. It reviews some of the approaches developed in the USSR concerning estimation of reliability of water supply and water demands and the use of these reliability estimates in the water resources planning process

Preliminary use of oxygen stable isotopes and the 1983 El Niño to assess the accuracy of aging black rockfish (Sebastes melanops)

Black rockfish (Sebastes melanops) range from California to Alaska and are found in both nearshore and shallow continental shelf waters (Love et al., 2002). Juveniles and subadults inhabit shallow water, moving deeper as they grow. Generally, adults are found at depths shallower than 55 meters and reportedly live up to 50 years. The species is currently managed by using information from an age-structured stock assessment model (Ralston and Dick, 2003)

The Columns, 1988 Spring

Cover Story, Proposed Pyramid Arena New Home for Tiger Basketball? On the cover is an exterior view of the proposed Pyramid arena which could be the future home court for MSU Tiger basketball. Shown here is an interior view of the arena with its planned 20,000 seats for basketball fans. Pyramid photos by Mike McElya \u2788. Also featured, MSU Pom-Pom Squad Three Time Champs MSU\u27s Pom-Pom Squad took top honors in the National Dance Competition in San Diego, CA in January, winning the event for the third consecutive year—that\u27s every time the competition has been held.https://digitalcommons.memphis.edu/speccoll-ua-alumni1/1079/thumbnail.jp