Exchange of Protein between Plasma and Ascites in the Inferior Vena Cava occluded Rabbits.

Disappearance from plasma and appearance in ascItes of T •1824 in the :nferior vena cava occluded rabbits were studied. 7 rabbits aB control and 11 rabbits as experimental group were studied. Ascites of about 80ml was produced about 10 days after partial occlusion (융 of natural diameter) of the inferior vena cava in the thorax. The following observations were made 1. Disappearance curve from plasma was consisted of two parts. e.g.. rapidly disappεaring and slowly disappearing parts 2. The rapidly disappearing part lasted up to 1.5 hour 274 • 5 4 -Duk Gyung Choi: Exchange of Protein between Plasma and Ascites in the Inferior Vena Cava occluded Rabbitsr after infusion of T-1824. Disappearance rate~in experimental group was significantly greater than ·in normal control group. 3. Per cent of T-1824 remaining in the circulation in control group was 81.9% at 1 hour , 66.5% at 2 hour , after infusion. The value in experimental group was 69.6% at 1 hour and 49.8% at 2 hour. 4. The equilibration time of exchange of T-1824 between plasma and ascites was 6-7 hours. 5. There was a decrease in total plasma protein in experimental group accompanied by a decrease in A/G ratio. This decrease was due to the decrease in plasma albumin. Albumin value was 3.95 gm/dl in normal and 3.09 gm/dl in experimental group. 6. Plasma sodium was decreased in experimental group. In normal rabbits sodium concentration was 160.8 mEq/l and 150.0 mEq/l in ascitic rabbits. 7. Histological change of liver was cirrhotic. 8. Computation was made that about 80 ml of Ascites was accumulated in the inferior vena cava occluded rabbits

Cardiac Output and its Fractional Distribution in the Thoracic Vena Cava Inferior occluded Rabbits

The effect of partial occlusion of thoracic vena cava inferior to 융 of its natural diameter on radio-iodinated serum albumin (RISA) dilution curve, Cardiac output, uptake of RISA by various organs, organ blood flow in rabbits were observed. 14 rabbits served as normal control group and rabbits were observed 30 minutes after the partial occlusion (acute group). In 10 rabbits observations were made about 10 days after the partial occlusion when ascites and liver cirrhosis appeared, which was confirmed postmortem (chronic group). The findings were as follows: 1. Time course of RISA dilution curve was shortened in occluded group. The shortening of time constants of RISA dilution curve was prominent in the ch rome group 2. There was an increase in cardiac output in the chronic group and no change in the acute group. Car diac index increased to 2.27 l/m2/min in the chronic group as compared to the control value of 1. 17 11m2 Imin. 3. Liver circulation was directly encroachα1 upon by the partial occlusion of thoracic vena cava inferior. Other regional circulation was far less affected by the partial occlusion than the liver circulation. 4. RISA uptake was greatest in liver in all 3 groups. There was an increased RISA uptake by liver in the chronic group, particularly. 5. Organ blood flow manifested the same behavior as the RISA uptake- There was an increased bl0여 flow in liver after partial occlusion. This increased liver blood flow was prominent in the chronic group where ascites and liver cirrhosis appeared

Blood volume in cobalt chloride induced polycythaemia of rats.

Polycythaemia was produced in 10 adult albino rats by administration of cobalt chloride. The total blood volume was measured with T-1824 and the values were compared to the normal control group (N=15). The following findings were obtained. 1. Red blood cell count, hematocrit value and hemoglobin concentration were significantly incr· eased in the experimental group. 2. Plasma volume of experimental group was 3.80土. 12ml/100 g and was significantly smaller than that of normal group, value being 4.14土.18 ml/100 g. 3. There was no difference of total blood volume between the two groups. Total blood volume was 7.41 土0.37 ml/100 gram. Thus, in cobalt administered rat, there was a normovolemic polycythaemi