Efficacy and Safety of Different Aceclofenac Treatments for Chronic Lower Back Pain: Prospective, Randomized, Single Center, Open-Label Clinical Trials

PURPOSE: Nonsteroidal anti-inflammatory drugs are a mainstay for medical treatment of chronic lower back pain (CLBP). Increased dose intervals for medication have been associated with increased patient adherence to prescriptions. The purpose of this clinical trial was to compare the efficacy and safety of a once daily dose of aceclofenac controlled release (CR) and a twice daily dose of aceclofenac for CLBP management. MATERIALS AND METHODS: A prospective, randomized, single center, open-label clinical trial was performed to compare the efficacy and safety of aceclofenac CR (200 mg once daily) to aceclofenac dose (100 mg twice daily). Fifty patients in each group were enrolled for the study. The primary end point was Visual Analogue Scale (VAS) change at baseline to that at 2 weeks after medication and safety profiles. Also, change in quality of life measured by EuroQoL 5D (EQ-5D) and Oswestry Disability Index (ODI) functional score for the lumbar spine were also assessed. RESULTS: Within groups at pre- and post-treatment, there were significant VAS reductions for aceclofenac CR and aceclofenac (p=0.028). EQ-5D increased significantly in both groups (p=0.037). ODI scores decreased significantly in both groups (p=0.012). However, there were no significant differences between aceclofenac CR and aceclofenac at pre- and post-treatment. Patients with aceclofenac CR showed significant increases in heartburn and indigestion and adverse gastrointestinal effects, compared to aceclofenac. CONCLUSION: In patients with CLBP, aceclofenac CR and aceclofenac demonstrated significant symptomatic pain relief, improvement in quality of life and functional scores. Aceclofenac CR slightly increased gastrointestinal adverse effects, such as heartburn and indigestion.ope

Study of verifying the effect which public service motivation has on service quality

학위논문 (석사)-- 서울대학교 대학원 : 행정학과(행정학전공), 2011.8. 임도빈.Maste

시장수익률의 예측치로서 장부가치 대 시장가치 비율의 능력에 관한 실증연구

학위논문(석사)--서울대학교 대학원 :경영학과 경영학전공,1999.Maste

Insecticidal activity of myristica fragrans seed-derived compounds against blatella germanica (Dictyoptera: Blattellidae)

Thesis(master`s)--서울대학교 대학원 :농생명공학부,2006.Maste

Growing rod technique for the treatment of the traumatic spinopelvic dissociation: a technical trick.

BACKGROUND CONTEXT: Traumatic spinopelvic dissociation, sometimes referred to as U-shaped sacral fracture, is a very rare high-energy trauma. The surgical management of spinopelvic dissociation includes decompression, reduction, and fixation. PURPOSE: We report a novel surgical technique for the treatment of spinopelvic dissociation that uses growing rods and a pedicle screw system, which is often used to treat patients with early onset scoliosis. STUDY DESIGN: This case report used a technical report of spinopelvic dissociation surgery using spinopelvic fixation and the growing rod technique. PATIENT SAMPLE: One case was used as the patient sample. OUTCOME MEASURE: Radiographic outcomes, including plain X-ray, three-dimensional computed tomography, and magnetic resonance imaging scan were the outcome measures. METHODS: The radiographic outcomes were compared preoperatively, postoperatively, and at the 1-year follow-up with bony union. RESULTS: Growing techniques improved traumatic sacral angulation, displacement, and canal encroachment, and provided sufficient structural support. CONCLUSION: The growing rod technique for spinopelvic dissociation under intraoperative neurophysiological monitoring could be a useful alternative surgical option, especially in patients without neurologic deficit.restrictio