Recurrence patterns after maximal surgical resection and postoperative radiotherapy in anaplastic gliomas according to the new 2016 WHO classification

We assessed the appropriateness of current radiotherapy volume for WHO grade III gliomas. The records of 73 patients with WHO grade III gliomas who received postoperative radiotherapy between 2001 and 2013 were retrospectively reviewed. Based on the 2016 WHO classification, 25/73 (34.2%) patients had anaplastic oligodendroglioma (AO), IDH-mutant and 1p/19q-codeleted; 11/73 (15.1%) patients had anaplastic astrocytoma, IDH-mutant; and 37/73 (50.7%) patients had anaplastic astrocytoma, IDH-wildtype. The extent of resection (EOR) was total in 43 patients (58.9%). The median follow-up time was 84 months. The 5-year overall survival was 65.4%. Of 31 patients with documented recurrences, 20 (64.5%) had infield gross tumor volume (GTV) failure, six (19.4%) had clinical target volume (CTV)/marginal failure, and five (16.1%) had outfield failure/seeding. In 13 recurrences among 43 patients who underwent gross total resection (GTR), six (46.2%) had infield CTV/marginal failure. However, among 30 patients for whom GTR was not conducted, infield GTV failure was dominant (77.8%). Seventeen patients with AO, IDH-mutant and 1p/19q-codeleted who underwent GTR experienced no recurrence. In conclusion, maximal surgical resection and postoperative radiotherapy resulted in a favorable prognosis, especially in patients with GTR, IDH mutation, and 1p/19q codeletion. Patterns of failure differed by EOR.ope

Role of Radiotherapy in the Multimodal Treatment of Ewing Sarcoma Family Tumors

PURPOSE: The aim of this study was to evaluate the role of radiotherapy (RT) in the management of Ewing sarcoma family tumors (ESFT). MATERIALS AND METHODS: Retrospective analysiswas performed on 91 patientswith localized ESFT treated from 1988 to 2012. Primary tumor size was ≥ 8 cm in 33 patients. Surgery, RT, and combined surgery with RT were applied in 37, 15, and 33 patients, respectively. RESULTS: Median follow-up was 43.8 months. Forty-three patients (47.3%) showed recurrence or progressive disease. Twelve patients (13.2%) showed local failure after initial treatment. Thirty-nine patients (42.9%) experienced distant metastases. The 5-year overall survival (OS), progression-free survival, and local control (LC) were 60.5%, 58.2%, and 85.1%, respectively. According to treatment, 5-year LCwas 64.8% with RT and 90.2% with combined surgery and RT (p=0.052). Prognostic factors for OS were tumor size (≥ 8 cm, p < 0.001) and surgical resection (p < 0.001). In large tumors (≥ 8 cm), combined surgery and RT produced better LC compared to RT (p=0.033). However, in smaller tumors (< 8 cm), RT without surgery resulted in a similar LC rate as RT with surgery (p=0.374). CONCLUSION: RT used for patients with unfavorable risk factors resulted in worse outcome than for patientswho received surgery. Smallertumors could be controlled locallywith chemotherapy and RT. For large tumors, combined surgery and RT is needed. Proper selection of local treatment modality, RT, surgery, or both is crucial in the management of ESFT.ope

Surgery Alone Versus Surgery Followed by Chemotherapy and Radiotherapy in Resected Extrahepatic Bile Duct Cancer: Treatment Outcome Analysis of 336 Patients

PURPOSE: This study analyzed the outcomes of patients with resected extrahepatic bile duct cancer (EHBDC) in order to clarify the role of adjuvant treatments in these patients. MATERIALS AND METHODS: A total of 336 patients with EHBDC who underwent curative resection between 2001 and 2010 were analyzed retrospectively. The treatment types were as follows: surgery alone (n=168), surgery with chemotherapy (CTx, n=90), surgery with radiotherapy (RT) alone (n=29), and surgery with chemoradiotherapy (CRT, n=49). RESULTS: The median follow-up period was 63 months. The 5-year rates of locoregional failure-free survival (LRFFS), distant metastasis-free survival (DMFS), progression-free survival (PFS), and overall survival (OS) for all patients were 56.5%, 59.7%, 36.6%, and 42.0%, respectively. In multivariate analysis, surgery with RT and CRT was a significant prognostic factor for LRFFS, and surgery with CTx was a significant prognostic factor for DMFS, and surgery with CTx, RT, and CRT was a significant prognostic factor for PFS (p < 0.05). Surgery with CTx and CRT showed association with superior OS (p < 0.05), and surgery with RT had marginal significance (p=0.078). In multivariate analysis of the R1 resection patients, surgery with CRT showed significant association with OS (p < 0.05). CONCLUSION: Adjuvant RT and CTx may be helpful in improving clinical outcomes of patients with resected EHBDC who have a high risk of disease recurrence, particularly R1 resection patients. Conduct of additional prospective, larger-scale studies will be required in order to confirm the benefit of adjuvant RT and CTx in these patients.ope

진단 시 원격전이된 자궁경부암 환자에서 방사선치료의 역할

Dept. of Medicine/석사Purpose: The objective of this study was to clarify the role of radiotherapy (RT) for patients presenting with disseminated cervical cancer at initial diagnosis.Patients and Methods: We retrospectively analyzed 77 patients diagnosed with disseminated cervical cancer between September 1980 and August 2012. All patients received external beam RT to the pelvis (median dose 45 Gy) and 60 patients (77.9%) treated with high dose rate brachytherapy (median dose 30 Gy). Sixty-four patients (83.1%) received chemotherapy and 12 patients (15.6%) underwent radical surgery including hysterectomy. We divided into two groups; 58 patients had distant lymph node metastasis only or peritoneal seeding without visceral organ metastasis (group A), 19 patients had visceral organ metastasis (group B).Results: Median follow-up time was 55 months (range, 15 to 296 months). The 5-year pelvic control rates (PCR), progression free survival (PFS), and overall survival (OS) were 83.7%, 25.1%, and 31.7%, respectively. On univariate analysis, OS rate of the group A were significantly better than that of group B (38.9% vs. 10.5%, P = .001). Multivariate analysis indicated that group B was the only significant independent prognostic factor for PFS and OS. Five-year PCR of group A and B were 82.6% and 89.5%, respectively.Conclusion: Our data suggests definitive RT be beneficial to disseminated cervical cancer patients without visceral organ metastasis. External beam pelvic RT alone might be considered to palliate symptom and delay pelvic progression in patients with visceral organ metastasis who are expected to have poor prognosis and need systemic chemotherapy.ope

Role of adjuvant radiotherapy in extrahepatic bile duct cancer: A multicenter retrospective study (Korean Radiation Oncology Group 18-14)

Purpose: To evaluate the role of adjuvant radiotherapy (RT) after curative resection in patients with extrahepatic bile duct (EHBD) cancer. Methods: Between January 2000 and December 2015, 1475 patients with EHBD cancer who underwent curative resection were accrued from 14 institutions in Korea. Among these, 959 patients did not receive any adjuvant therapy (RT(-) group), while 516 underwent postoperative RT with or without chemotherapy (RT(+) group). Results: The median age was 67 years. Nodal involvement was present in 482 patients (32.7%), and resection margin was involved in 293 patients (19.9%). RT(+) group had more patients with proximal tumours, advanced tumours, nodal involvement, perineural invasion, and involved resection margin than RT(-) group (all p < 0.001). With a median follow-up of 36 months, there were 211 locoregional recurrences, 307 distant metastases and 322 combined locoregional and distant failures. On multivariate analysis incorporating age, tumour location, differentiation, pT classification, pN classification, perineural invasion and resection margin, adjuvant RT was associated with improved overall survival (hazard ratio, 0.74; 95% confidence interval, 0.63-0.86; p < 0.001). When RT(+) group was separated into RT alone, concurrent chemoradiotherapy (CCRT) and CCRT followed by chemotherapy, the greatest benefit was observed in patients treated with CCRT followed by chemotherapy (hazard ratio, 0.52; 95% confidence interval, 0.41-0.68). Conclusions: Adjuvant RT combined with chemotherapy improved survival outcomes of resected EHBD cancer patients. Considering the greatest benefit observed in patients receiving CCRT followed by chemotherapy, a randomised controlled trial comparing chemotherapy alone and CCRT followed by chemotherapy is urgently needed.restrictio

인터넷을 이용한 온실 감시 시스템의 개발

학위논문(석사)--서울대학교 대학원 :생물자원공학부 농업기계전공,2001.Maste

산업간 연구개발 파급효과 (R&D Spillover Effects) 분석 : 식음료 산업을 중심으로

학위논문(석사)--서울대학교 대학원 :농경제사회학부,2004.Maste

METOHD OF in situ preparATION OF a metal-organic framework from a diffusion-control within an ionic polymer

본 개시는 1) 음이온성 고분자 함유 용액 및 유기 리간드 전구체 용액을 혼합하여 혼합 용액을 제조하는 단계; 및 2) 상기 혼합 용액에 금속염을 가하는 단계;를 포함하는 금속-유기 구조체(MOF)-함유 매트릭스의 제조방법을 제공한다. 또한, 본 개시는 상기 제조방법에 따라 제조된 금속-유기 구조체 함유 매트릭스, 및 이를 포함하는 흡착제를 제공한다. 나아가, 본 개시는 상기 제조방법에 따라 제조된 금속-유기 구조체 함유 매트릭스를 이용하여 유체를 분리하는 방법을 제공한다

Clinical safety and efficacy of salvage reirradiation for upper abdominal malignancies

PURPOSE: Reirradiation has the potential to provide effective local control of upper abdominal malignancies. This study aimed to evaluate the safety and efficacy of reirradiation for upper abdominal malignancies. METHODS: A total of 42 patients with a history of prior radiotherapy (RT) received reirradiation for abdominal malignancies between 2005 and 2017. Each patient's medical records, contours, and dose distribution for both RT courses were reviewed. The median dose of the prior RT was 50.0 Gy (range, 30.0-60.0 Gy) and the median dose of reirradiation was 45.0 Gy (range, 15.0-75.0 Gy). RESULTS: With a median follow-up of 10.9 months, the median infield-failure-free survival (IFFS) rate was 9.2 months. Gross tumor volume (GTV) significantly related to IFFS in both the univariate (p = 0.009) and multivariate analyses (p = 0.024), and patients with a GTV of 60.0 Gy (range, 60.1-73.7 Gy). In the univariate analysis, the D2cc of the duodenum and a preexisting duodenal ulcer identified using endoscopy prior to reirradiation significantly correlated with late severe toxicity (p = 0.021 and 0.017, respectively). CONCLUSIONS: Reirradiation for upper abdominal malignancies could be safely performed for patients without preexisting gastrointestinal morbidity unless the duodenum received excessive radiation doses. Reirradiation could also provide substantial IFFS, especially for patients with a GTV of <60.0 mL.restrictio

METHOD FOR PREPARING, IN SITU, METAL-ORGANIC FRAMEWORK BY USING CONTROL OF DIFFUSION WITHIN IONIC POLYMER

Disclosed is a method for preparing a matrix containing metal-organic frameworks (MOFs), comprising the steps of: 1) mixing an organic ligand precursor solution and an anionic polymer-containing solution to produce a mixed solution; and 2) adding a metal salt to the mixture solution. In addition, the present disclosure provides a matrix containing MOFs prepared according to the preparation method, and an adsorbent comprising the same. Furthermore, a method for performing fluid separation by using a matrix containing MOFs prepared according to the preparation method is disclosed