25 research outputs found

    ๋ถ€์‹ค๊ธฐ์—… ๊ณต์‹œ์˜ ์ •๋ณด์ด์ „ํšจ๊ณผ์— ๊ด€ํ•œ ์—ฐ๊ตฌ

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    ํ•™์œ„๋…ผ๋ฌธ(์„์‚ฌ)--์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› :๊ฒฝ์˜ํ•™๊ณผ ๊ฒฝ์˜ํ•™์ „๊ณต,2001.Maste

    ์ง‘ํ•ฉ์ฑ„๊ถŒ์–‘๋„๋‹ด๋ณด์™€ ๋„์‚ฐ๋ฒ•์ƒ ๋ถ€์ธ๊ถŒ

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    ํ•™์œ„๋…ผ๋ฌธ(์„์‚ฌ)--์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› :๋ฒ•ํ•™๊ณผ,2006.Maste

    (A) study on microorganisms in saliva and in extraction sockets of humans

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    ์น˜์˜ํ•™๊ณผ/์„์‚ฌ[ํ•œ๊ธ€] ๊ตฌ๊ฐ•๋‚ด๋Š” ๋งŽ์€ ๋ฏธ์ƒ๋ฌผ์ด ์กด์žฌํ•œ๋‹ค. ๊ตฌ๊ฐ•์€ ํ˜€, ํ˜‘์ ๋ง‰, ์น˜์•„, ์น˜์€์—ด๊ตฌ๋“ฑ์˜ ํ•ด๋ถ€ํ•™์  ๊ตฌ์กฐ๊ฐ€ ๋ฏธ์ƒ๋ฌผ์ด ์ง‘๋ฝํ•˜๊ธฐ ์ข‹์€ ๋ถ€์œ„์ด๋ฉฐ ์ด๋Ÿฐ ํ•ด๋ถ€ํ•™์  ํŠน์„ฑ ์ด์™ธ์—๋„ ์ƒ๋ฆฌ์  ๊ธฐ๋Šฅ์  ํŠน์„ฑ์œผ๋กœ ์„ฑ์žฅํ•˜๊ธฐ์— ์ข‹์€ ์˜จ๋„ ์Šต๋„๋“ฑ์„ ์ œ ํ•œ๋‹ค. ์—ฌ๋Ÿฌ ์„ ํ•™๋“ค์˜ ์—ฐ๊ตฌ์— ์˜ํ•˜๋ฉด ๊ทธ๊ฒƒ๋“ค์€ ์น˜์„ฑ๊ฐ์—ผ์‹œ ๋ณ‘์›๊ท ์œผ๋กœ ์ž‘์šฉ๊ฐ€๋Šฅํ•˜๋‹ค. ๊ทธ๋ ‡์ง€๋งŒ ๋‹จ์ˆœ๋ฐœ์น˜ํ›„ ๋ฐœ์น˜์™€๋‚ด์—์„œ ๋ฐœ๊ฒฌ๋˜๋Š” ์„ธ๊ท ๋“ค์— ๊ด€ํ•œ ์—ฐ๊ตฌ๊ฐ€ ์ ์–ด ๋ฐœ์น˜ํ›„ ์•ผ๊ธฐ๋  ์ˆ˜ ์žˆ๋Š” ๊ฐ์—ผ์ฆ์˜ ์˜ˆ๋ฐฉ ๋ฐ ์น˜๋ฃŒ์— ํฐ ๋„์›€์„ ์–ป๊ณ ์ž ์ €์ž๋Š” ์น˜์ฃผ์งˆํ™˜ ๋ฐ ์น˜๊ทผ๋‹จ์—ผ์ฆ์œผ๋กœ ์ธํ•ด ๋ฐœ์น˜๋ฅผ ํ•„์š”๋กœ ํ•˜๋Š” ํ™˜์ž 50๋ช…์— ๋Œ€ํ•ด ๋ฐœ์น˜์ „ ํƒ€์•ก๋‚ด์™€ ๋ฐœ์น˜์งํ›„ ๋ฐœ์น˜์™€๋‚ด์˜ ์„ธ๊ท ์„ ํ˜ธ๊ธฐ์„ฑ๊ณผ ํ˜๊ธฐ์„ฑ์œผ๋กœ ๋ถ„๋ฆฌ๋™์ •ํ•˜์—ฌ ๋‹ค์Œ๊ณผ ๊ฐ™์€ ๊ฒฐ๋ก ์„ ์–ป์—ˆ๋‹ค. 1. ์ „์ฒด ๋ถ„๋ฆฌ๋œ ๊ท ์ฃผ๋Š” 563์ฃผ์˜€๋‹ค. ์ด๊ฒƒ์€ 1์ธํ‰๊ท  11.3์ฃผ ๋ถ„๋ฆฌ๋œ ๊ฒƒ์ด๋‹ค. 2. ์ „์ฒด ํ˜ธ๊ธฐ์„ฑ, ํ˜๊ธฐ์„ฑ ๋ถ„๋ฆฌ๊ท ์ฃผ๋Š” ๊ฐ๊ฐ 355์ฃผ, 208์ฃผ์˜€๋‹ค. ์ด๊ฒƒ์€ 1์ธํ‰๊ท  7.1์ฃผ, 4.2์ฃผ ๋ถ„๋ฆฌ๋œ ๊ฒƒ์ด๋‹ค. 3. ํƒ€์•ก๋‚ด์™€ ๋ฐœ์น˜์™€๋‚ด์˜ ๋ถ„๋ฆฌ๊ท ์ฃผ๋Š” 276์ฃผ, 287์ฃผ์˜€๋‹ค. ๊ฐ๊ฐ์˜ ํ˜ธ๊ธฐ์„ฑ, ํ˜๊ธฐ์„ฑ ๊ท ์ฃผ๋Š” 184์ฃผ์™€ 92์ฃผ ๋ฐ 171์ฃผ์™€ 116์ฃผ์˜€๋‹ค. 4. ํƒ€์•ก๊ณผ ๋ฐœ์น˜์™€์˜ ๋น„๊ต์‹œ ๊ฐ€์žฅ ๋นˆ๋„์ˆ˜๊ฐ€ ๋†’์€ ๊ฒƒ์€ ๋‹ค์Œ์˜ ๊ฒƒ๋“ค์ด๋‹ค.; ํƒ€์•ก ํ˜ธ๊ธฐ์„ฑ Streptococcus viridans 45์ฃผ (24%) Haemophilus parainfluenzae 33์ฃผ (18%) Branhamella catarrhalis 29์ฃผ (16%) ํ˜๊ธฐ์„ฑ Bacteroides Oralis 22์ฃผ (24%) Bacteroides melaninogenicus 13์ฃผ (14%) Anaerobic streptococcus 10์ฃผ (11%) ๋ฐœ์น˜์™€ ํ˜ธ๊ธฐ์„ฑ Streptococcus viridans 42์ฃผ (25%) Branhamella catarrhalis 31์ฃผ (18%) Haemophilus parainfluenzae 26์ฃผ (15%) ํ˜๊ธฐ์„ฑ Bacteroides Oralis 24์ฃผ (21%) Bacteroides melaninogenicus 23์ฃผ (20%) Fusobacterium nucleatum 11์ฃผ ( 9%) [์˜๋ฌธ] There are many microorganisms in oral cavity. Numerous factors may influence on the com-position of oral flora. By the studies of previous investigators, they possibly act as a pathogens in odontogenic infections. But there was no description of the organisms which are found in the simple extraction socket immediately after the tooth has been removed. If the valid theories are to be advanced concerning the relationship to postoperative inflammation, knowledge of the early bacterial study is essential. Fifty-patients were chosen for this study who visited Catholic Medical College Hospital, department of dentistry, during the period of March to May 1984 under the diagnosis of pulpitis and periodontitis. They all had been swabbed from saliva. And with local anesthesia, all had been pulled out single tooth. From the extraction socket, swabbing had been done like sampling of saliva. Those samplings were transported to the laboratory as soon as possible and cultured aerobically : anaerobically. The obtained results were as follows; 1. Total cultured strains were 565 strains. The average number of bacteria identified was 11.2 strains per person. 2. Total aerobic strains were identified 355, anaerobes,208 with the average of 7.1 and 4.1 strains per person respectively. 3. Total cultured strains of saliva were 276 strains. Total cultured strains of Extraction socket were 287 strains. Their aerobes and anaerobes were 184,92 strains, and 171,116 strains respectively. 4. In comparison between bacterial species in saliva and extraction socket, moat frequently identified groups were as follows; In saliva aerobic groups were streptococcus viridans 45 strains (24%) Haemophilus patwainfluenzae 33 strains (18%) Branhamella catarrhalis 29 strains (16%) Anaerobic groups were Bacteroides oralis 22 strains (24%) Bactoroides melanioosicus 13 strains (14%) anaerobic streptococci 10 strains (11%) In extraction socket aerobic groups were streptococcus viridans 42 strains (25%) Branhamella catarrhalis 31 strains (18%) Haemophilos p arainfluenzae 26 strains (15%) anaerobic froup were Bacteroides oralis 24 strains (21%) Bactreoides melaninogenicus 23 strains (20%) Fusobactreium nucleatum 11 strains (9%)restrictio

    Galerkin๋ฐฉ๋ฒ•์„ ์ด์šฉํ•œ ๊ณ ์ฐจ ํฌ๋ฌผ์„  ๋ฐฉ์ •์‹ ์ˆ˜์ค‘์Œ ์ „๋‹ฌ ํ•ด์„

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    ํ•™์œ„๋…ผ๋ฌธ(์„์‚ฌ)--์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› :์กฐ์„ ํ•ด์–‘๊ณตํ•™๊ณผ,1999.Maste

    Effects of vitamin E on the hamster buccal pouch carcinogenesis induced by 9,10-dimethyl-1,2-benzanthracene (DMBA)

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    ์น˜์˜ํ•™๊ณผ/๋ฐ•์‚ฌ[ํ•œ๊ธ€] ์Œ์‹๋ฌผ์˜ ์„ญ์ทจ์™€ ์•”๋ฐœ์ƒ๊ณผ์˜ ๊ด€๋ จ์„ฑ์— ๋Œ€ํ•ด ์ตœ๊ทผ ๋งŽ์€ ํ•™์ž๋“ค์˜ ๊ด€์‹ฌ์˜ ๋Œ€์ƒ์ด ๋˜๊ณ  ์žˆ๋‹ค. vitamin A, ฮฒ- carotene, ascorbic acids, retinoids, ฮฑ- tocopherol์˜ ์˜์–‘์š”์†Œ ์™ธ์—๋„ alcohol๊ณผ coffee, ์ง€๋ฐฉ, ์•ผ์ฑ„์˜ ์„ญ์ทจ๊ฐ€ ์—ฐ๊ตฌ์˜ ๋Œ€์ƒ์ด ๋˜์–ด์™”์œผ๋ฉฐ Watson๊ณผ Leonard๋Š” ๋‚จ์„ฑ์—๊ฒŒ ๋ฐœ์ƒ๋˜๋Š” ์•”์˜ 30โˆผ40%์™€ ์—ฌ์„ฑ์˜ ๊ฒฝ์šฐ์—๋Š” 60%๊ฐ€ ์„ญ์ทจํ•˜๋Š” ์Œ์‹๋ฌผ๊ณผ ๊ด€๋ จ์ด ๋œ๋‹ค๊ณ  ์–ธ๊ธ‰ํ•˜์˜€๋‹ค. vitamin E(ฮฑ- tocopherol)๋Š” ์ง€์šฉ์„ฑ vitamin์˜ ์ผ์ข…์œผ๋กœ ๊ณผ์‚ฐํ™”์ง€์งˆ์„ ์˜ˆ๋ฐฉํ•˜๋ฉฐ, ๋…์„ฑ๋ฌผ์งˆ์— ๋Œ€ํ•ด ๋ณดํ˜ธ์ž‘์šฉ๊ณผ ๋ฉด์—ญ ์ฆ์ง„ํšจ๊ณผ๊ฐ€ ์žˆ๋‹ค๊ณ  ์•Œ๋ ค์ ธ ์žˆ์œผ๋ฉฐ ์œ„์žฅ๊ด€์—์„œ ํก์ˆ˜๊ฐ€ ์ž˜๋˜๋ฉฐ ์ผ์ •๋Ÿ‰์„ ๊ณ„์† ํˆฌ์—ฌ์‹œ ์ˆ˜์ฃผ ๊ฒฝ๊ณผํ›„ ์‹ ์ฒด์กฐ์ง์—์„œ ์ผ์ • ๋†๋„๋ฅผ ์œ ์ง€ํ•œ๋‹ค. ์ €์ž๋Š” ์ด์™€ ๊ฐ™์€ ์„ฑ์งˆ์„ ๊ฐ€์ง„ vitamin E๊ฐ€ ์•”๋ฐœ์ƒ์— ๋ฏธ์น˜๋Š” ์˜ํ–ฅ๊ณผ ์žฅ๊ธฐ๋ณต์šฉ์‹œ ํ•ญ์•”๋ˆ„์ ํšจ๊ณผ ์—ฌ๋ถ€๋ฅผ ์—ฐ๊ตฌํ•˜๊ณ ์ž ์ƒํ›„ 2โˆผ3๊ฐœ์›”๋œ ์ฒด์ค‘ 100g๋‚ด์™ธ์˜ golden syrian hamster (Mesocricetus auratus) 75๋งˆ๋ฆฌ๋ฅผ ์ •์ƒ๊ตฐ ๋ฐ ๋Œ€์กฐโ… , โ…ก๊ตฐ, ๊ฐ 5๋งˆ๋ฆฌ์”ฉ๊ณผ ์‹คํ—˜โ… , โ…ก, โ…ข๊ตฐ ๊ฐ 20๋งˆ๋ฆฌ์”ฉ ๊ตฌ๋ถ„ํ•˜์—ฌ ๋Œ€์กฐ๊ตฐ์€ ํฌ์„์šฉ๋งค์ธ heavy mineral oil๋งŒ์„, ์‹คํ—˜โ… , โ…ก, โ…ข๊ตฐ์€ 0.5% DMBA(9, 10-dimethyl-1, 2-benzanthracene)๋ฅผ heavy mineral oil์— ์šฉํ•ดํ•˜์—ฌ No.2 brush๋ฅผ ์‚ฌ์šฉํ•˜์—ฌ ์ฃผ 3ํšŒ hamster ์ขŒ์ธก ํ˜‘๋‚ญ์ ๋ง‰์— ๊ฒฉ์ผ ๊ฐ„๊ฒฉ์œผ๋กœ ๋„ํฌํ•˜์˜€์œผ๋ฉฐ vitamin E ํˆฌ์—ฌ๋Š” 10 IU ๋ฅผ ์‹œํŒ๋˜๋Š” ์‹์šฉ์œ  0.2cc์— ๋…น์—ฌ ๋Œ€์กฐโ…ก๊ตฐ๊ณผ ์‹คํ—˜โ…ก๊ตฐ์€ ๋„ํฌ์™€ ๋™์‹œ์—, ์‹คํ—˜โ…ข๊ตฐ์€ ๋„ํฌ 4์ฃผ ์ „๋ถ€ํ„ฐ ์ฃผ 2ํšŒ ๋„ํฌ ์•ˆํ•˜๋Š” ์š”์ผ์„ ์„ ํƒํ•˜์—ฌ ํˆฌ์—ฌํ•˜์˜€๋‹ค. ๋„ํฌ์‹œ์ž‘ 8์ฃผ์งธ ๋ถ€ํ„ฐ 2์ฃผ ๊ฐ„๊ฒฉ์œผ๋กœ 16์ฃผ๊นŒ์ง€ ๋Œ€์กฐ๊ตฐ๊ณผ ์ •์ƒ๊ตฐ์˜ ๊ฐ ํ•œ ๋งˆ๋ฆฌ์”ฉ, ์‹คํ—˜๊ตฐ์˜ 4๋งˆ๋ฆฌ์”ฉ์„ ํฌ์ƒ์‹œ์ผœ ์ขŒ ์ธก ํ˜‘๋‚ญ์ ๋ง‰์„ ์œก์•ˆ์œผ๋กœ ๊ด€์ฐฐํ•˜์—ฌ ์•”๋ฐœ์ƒ ์ข…๋ฌผ์ด ์žˆ๋Š” ๊ฒฝ์šฐ ํฌ๊ธฐ๋ฅผ ์žฌ๊ณ , ๋ฐœ์ƒ ๊ฐฏ์ˆ˜๋ฅผ ๊ธฐ๋กํ•œ ํ›„์— ํ†ต๊ณ„์ฒ˜๋ฆฌํ•˜์˜€๊ณ  ์•”์กฐ์ง์„ ์ ˆ์ œํ•˜์—ฌ ํ‘œ๋ณธ ์ œ์ž‘ํ›„ ๊ด‘ํ•™ํ˜„๋ฏธ๊ฒฝ์œผ๋กœ ๊ฒ€๊ฒฝํ•˜๊ณ  ๋ฐœ์ƒ๋œ ์•”์กฐ์ง์€ ์ „์žํ˜„๋ฏธ๊ฒฝ์œผ๋กœ๋„ ๊ด€์ฐฐํ•˜์—ฌ ๋‹ค์Œ๊ณผ ๊ฐ™์€ ๊ฒฐ๋ก ์„ ์–ป์—ˆ๋‹ค. 1. vitamin E๋ฅผ ํˆฌ์—ฌํ•œ ์‹คํ—˜โ…ก, โ…ข๊ตฐ์€ ์‹คํ—˜โ… ๊ตฐ์— ๋น„ํ•ด ์•”๋ฐœ์ƒ ๊ณผ์ •์˜ ์ง€์—ฐ๊ณผ ๋ฐœ์ƒ๋œ ์ข…๋ฌผ์˜ ํฌ๊ธฐ์™€ ๊ฐฏ์ˆ˜์—์„œ ์ฐจ์ด๊ฐ€ ์žˆ์—ˆ์œผ๋‚˜ ์‹คํ—˜โ…ก๊ตฐ๊ณผ โ…ข๊ตฐ๊ฐ„์˜ ์ฐจ์ด๋Š” ์—†์—ˆ๋‹ค. 2. ์‹คํ—˜โ… ๊ตฐ์€ 8์ฃผ์—๋Š” ๊ฒฝ๋„์˜ ์ดํ˜•์„ฑ์†Œ๊ฒฌ๊ณผ ๊ณผ๊ฐํ™”์ฆ, ๊ทน์„ธํฌ์ฆ์˜ ์ƒํ”ผ์ฆ์‹์†Œ๊ฒฌ์ด ๊ด€์ฐฐ๋˜๊ณ  10์ฃผ์— ์ƒํ”ผ๋‚ด์•”๊ณผ ์ดํ˜•์„ฑ์†Œ๊ฒฌ์ด, 12์ฃผ์— ์นจ์œค์„ฑ ์ƒํ”ผ์•”์ด ์ผ๋ถ€์—์„œ ๊ด€์ฐฐ๋˜๊ณ , 14, 16์ฃผ์‹œ์—๋Š” ์ง„ํ–‰๋œ ์นจ์œค์„ฑ ์ƒํ”ผ์•”๊ณผ ์ƒํ”ผ๋‚ด์•”์ด ๊ด€์ฐฐ๋˜์—ˆ๋‹ค. 3. ์‹คํ—˜โ…ก๊ตฐ์€ 8์ฃผ์— ์ƒํ”ผ์ฆ์‹์†Œ๊ฒฌ, 10์ฃผ์— ์ƒํ”ผ๋‚ด์•”๊ณผ ๊ฒฝ๋„์น˜ ์ดํ˜•์„ฑ์†Œ๊ฒฌ, 12์ฃผ์— ๊ทนํžˆ ์ดˆ๊ธฐ์˜ ์นจ์œค์„ฑ ์ƒํ”ผ์•”์ด ๋™๋ฐ˜๋œ ์ƒํ”ผ๋‚ด์•”, 14, 16์ฃผ์‹œ ์นจ์œค์„ฑ ์ƒํ”ผ์•”๊ณผ ์ƒํ”ผ๋‚ด์•”์ด ๊ด€์ฐฐ๋˜์—ˆ๋‹ค. 4. ์‹คํ—˜โ…ข๊ตฐ์€ 8์ฃผ์— ๊ฒฝ๋„์˜ ์ดํ˜•์„ฑ์†Œ๊ฒฌ, 10์ฃผ์—๋Š” ์ค‘๋“ฑ๋„์˜ ์ดํ˜•์„ฑ์†Œ๊ฒฌ์ด, 12์ฃผ์— ์ƒํ”ผ๋‚ด์•”๊ณผ ์ดํ˜•์„ฑ์ฆ, 14์ฃผ์— ์นจ์œค์„ฑ ์ƒํ”ผ์•”, 16์ฃผ์— ์นจ์œค์„ฑ ์ƒํ”ผ์•”๊ณผ ์ƒํ”ผ๋‚ด์•”์ด ๊ด€์ฐฐ๋˜์—ˆ๋‹ค. 5. ์ „์žํ˜„๋ฏธ๊ฒฝ ์†Œ๊ฒฌ์€ ๊ฐ๊ตฐ ๊ณตํžˆ ์•”๋ฐœ์ƒ์— ๋”ฐ๋ผ ์„ธํฌ๊ฐ„๊ฒฉ์ด ๋„“์–ด์ง€๊ณ  ์„ธํฌ์งˆ๋Œ๊ธฐ์˜ ์ถœํ˜„, ๊ต์†Œ์ฒด์˜ ๊ฐ์†Œ, ๋ถˆ๊ทœ์น™ํ•œ ์„ธํฌํ•ต, ์žฅ์›์„ฌ์œ ์˜ ๊ตฐ์ง‘๋“ฑ์„ ๋ณด์ด๋Š” ์ž˜ ๋ถ„ํ™”๋œ ํŽธํ‰์ƒํ”ผ์•” ์†Œ๊ฒฌ์„ ๋‚˜ํƒ€๋ƒˆ๋‹ค. ์ด์ƒ์˜ ๊ฒฐ๊ณผ vitamin E๋Š” ์•”๋ฐœ์ƒ ์ง€์—ฐํšจ๊ณผ๊ฐ€ ์ธ์ •๋˜๋ฉฐ ๋ฐœ์•”์ „ ์‚ฌ์ „ํˆฌ์—ฌ์— ์˜ํ•œ ํ•ญ์•”๋ˆ„์ ํšจ๊ณผ๋Š” ๋ถˆํ™•์‹คํ•˜๋‹ค๊ณ  ์‚ฌ๋ฃŒ๋œ๋‹ค. [์˜๋ฌธ] The relationship of nutritional supplements and cancer is receiving renewed attention. Vitamin E(ฮฑ-tocopherol) is accepted one of essential nutrients for man and thought to have antioxidant function and free radical scavenger action and etc. The present study was undertaken to investigate the effect of vitamin E on the hamster buccal pouch carcinogenesis induced by DMBA. 75 syrian golden hamster (Mesocricetus auratus), 6 weeks old, were used in this experiment and were divided into normal(5), control โ… , โ…ก(10), experimental group โ… , โ…ก, โ…ข(60). In experimental group and control group, the left buccal pouch of hamster was painted three times a week with 0.5% DMBA in heavy mineral oil and only heavy mineral oil respectively. But in experimental group โ…ก and control group โ…ก, animals received 10 IU of vitamin E twice a week on days alternate to the DMBA painting. In experimental group โ…ข, animals received vitamin E also, but they received 4 weeks before DMBA painting in order to investigate the long term effect of vitamin E. All animals were sacrified serially at 8th, 10th, 12th, 14th, and 16th week. Buccal pouches were photographed and excised. Tumors in the left buccal pouches were measured and counted for statistical analysis. Excised tissues were examined light-and eclectromicroscopically. The results were as follows; 1. In experimental group โ…ก, โ…ข received vitamin E, there was a significant delay in tumor formation up to 12 weeks, and that from 12 to 16 weeks, there were fewer tumors and their average size was smaller than group โ… . But there was no difference between group โ…ก and โ…ข. 2. In experimental group โ… , mild dysplasia with hyperkeratosis and acanthosis was observed at 8 weeks, carcinoma-in-situ and dysplasia at 10 weeks, frankly invasive carcinoma at 12 weeks, extensive tumors with invasion and surface necrosis at 14, 16 weeks. 3. In experimental group โ…ก, hyperkeratosis and acanthosis was observed at 8 weeks, carcinoma-in-situ and mild dysplasia at 10 weeks, frankly invasive carcinoma at 12 weeks, invasive carcinoma and carcinoma-in-situ at 14, 16 weeks. 4. In experimental group โ…ข, mild dysplasia and hyperkeratosis was observed at 8 weeks, moderate dysplasia at 10 weeks, carcinoma-in-situ and dysplasia at 12 weeks, invasive carcinoma and carcinoma-in-situ at 14, 16 weeks. 5. Electromicroscopic studies of developed tumors in each group observend moderately differentiated type of epidermoid carcinoma. They showed nuclear pleomorphism, clumping of tonofilaments, less frequent number of desmosomes widened intercellular spaces with microvillus-like structures and degenerated mitochondria. This results suggest that vitamin E has some inhibition effects on carcinogenesis but there was no long term effect of vitamin E.restrictio

    Using implants for worn dentition with the altered vertical dimension of occlusion based on shortened dental arch concept: a case report

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    ๊ณผ๋„ํ•œ ๋งˆ๋ชจ ๊ฐ™์€ ์ž”์กด ์น˜์•„ ๊ตฌ์กฐ์˜ ํŒŒ๊ดด๋Š” ์ „์น˜์œ ๋„์™€ ์ €์ž‘ ๊ธฐ๋Šฅ์— ์‹ฌ๊ฐํ•œ ์†์ƒ์„ ์ดˆ๋ž˜ํ•  ์ˆ˜ ์žˆ๋‹ค. ์ด๋Ÿฐ ์ฆ์ƒ์„ ๊ฐœ์„ ์‹œํ‚ค๊ธฐ ์œ„ํ•ด์„œ๋Š” ์ƒ์‹ค๋œ ๊ตฌ์น˜๋ถ€๋ฅผ ์ˆ˜๋ณตํ•˜์—ฌ ์ ์ ˆํ•œ ๊ตํ•ฉ์„ ํšŒ๋ณต์‹œ์ผœ์ฃผ๋Š” ๊ฒƒ์ด ํ•„์ˆ˜์ ์ด๋‹ค. ๊ตฌ์น˜๋ถ€์˜ ๋ฌด์น˜์•…๋ถ€๋ฅผ ์ˆ˜๋ณตํ•˜๊ธฐ ์œ„ํ•ด์„œ๋Š” ์˜์น˜๋‚˜ ์ž„ํ”Œ๋ž€ํŠธ๊ฐ€ ์‚ฌ์šฉ๋  ์ˆ˜ ์žˆ๋Š”๋ฐ, ์ž„ํ”Œ๋ž€ํŠธ๋กœ ์ˆ˜๋ณต์‹œ์—๋Š” ๊ฒฝ์ œ์ ์ธ ์ œ์•ฝ์œผ๋กœ ์œ„ํ•ด shortened dental arch ๊ฐœ๋…์„ ์ ์šฉํ•˜๋Š” ๊ฒƒ์ด ์œ ๋ฆฌํ•  ์ˆ˜ ์žˆ๋‹ค. ๋ณธ ์ฆ๋ก€๋Š” 86์„ธ ๋‚จํ™˜์œผ๋กœ, ๋‹ค์ˆ˜์˜ ์น˜์•„๊ฐ€ ์ƒ์‹ค๋˜์–ด ์žˆ์—ˆ๊ณ , ๊ตฌ์น˜๋ถ€ ๊ตํ•ฉ์˜ ๋ถ•๊ดด์™€ ๊ณผ๋„ํ•œ ์น˜์งˆ ์†Œ์‹ค, ์ˆ˜์ง ํ”ผ๊ฐœ๋ฅผ ๊ด€์ฐฐํ•  ์ˆ˜ ์žˆ์—ˆ๋‹ค. ๊ตฌ์น˜๋ถ€์—์„œ ๋ถ•๊ดด๋œ ๊ตํ•ฉ์„ ์žฌํ˜•์„ฑํ•ด์ฃผ๋Š” ๊ฒƒ์„ ์ตœ์šฐ์„  ๊ณผ์ œ๋กœ ์ •ํ•˜์˜€์œผ๋ฉฐ, ๊ฐ€์ฒ ์„ฑ ๋ณด์ฒ ๋ฌผ ๋Œ€์‹ , ๊ตญ๋ฏผ๊ฑด๊ฐ•๋ณดํ—˜์ด ์ ์šฉ๋œ 2๊ฐœ์˜ ์ž„ํ”Œ๋ž€ํŠธ์™€ ๊ณ ์ •์„ฑ ๊ตญ์†Œ์˜์น˜, ๋ ˆ์ง„์„ ์ด์šฉํ•˜์—ฌ ๋ณด์ฒ  ์ˆ˜๋ณต์„ ์™„๋ฃŒํ•˜์˜€๋‹ค. ์†Œ๊ตฌ์น˜ ๋ถ€์œ„์—์„œ 2 mm์˜ ์ˆ˜์ง๊ณ ๊ฒฝ์„ ๊ฑฐ์ƒํ•˜์˜€์œผ๋ฉฐ, shortened dental arch ๊ฐœ๋…์„ ์ ์šฉํ•˜์˜€๋‹ค. ์ด๋ฅผ ํ†ตํ•ด ์ „์•… ์ˆ˜๋ณต์— ๋น„ํ•˜์—ฌ ์ ์€ ๋น„์šฉ์œผ๋กœ ์ด๋ฅผ ๋Œ€์ฒดํ•˜๋Š” ์น˜๋ฃŒ๋ฅผ ๊ณ ์ •์„ฑ ๋ณด์ฒ ๋ฌผ๋กœ ํ•  ์ˆ˜ ์žˆ์—ˆ์œผ๋ฉฐ, ์‹ฌ๋ฏธ์ , ๊ธฐ๋Šฅ์ ์œผ๋กœ ์–‘ํ˜ธํ•œ ๊ฒฐ๊ณผ๋ฅผ ์–ป์—ˆ๋‹ค.N
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