전이금속 촉매 하에 말단 알카인의 산화적 α–첨가 및 β–알킬화 반응

학위논문 (석사)-- 서울대학교 대학원 : 화학부, 2017. 2. 이철범.Described in this dissertation is the development of the transition metal-catalyzed cyclization and oxygenative nucleophilic addition of terminal alkynes which gives cyclopentane and cyclohexane carboxylic acid derivatives as products. Using terminal alkynes tethered with electrophiles such as alkyl halides, aldehydes, imines, and Michael acceptors, the reaction can be carried out with a broad range of nucleophiles such as alcohols and amines in the presence of a suitable base, oxidant and rhodium catalyst. The proposed mechanism involves the formation of a disubstituted metal vinylidene intermediate via β-alkylation followed by transfer oxygenation to form a metalloketene which then undergoes nucleophilic addition. This transformation can provide diverse ester and amide products while forming a 5- and 6-membered ring moiety.ABSTRACT 1 INTRODUCTION 2 RESULT AND DISCUSSION 6 CONCLUSION 27 EXPERIMENTAL SECTION 28 REFERENCES 77 ABSTRACT (IN KOREAN) 78 SPECTRA 79Maste