Magnetic resonance imaging and pathological characteristics of pure mucinous carcinoma in the breast according to echogenicity on ultrasonography

PURPOSE: The aim of this study was to explore the clinical and pathological characteristics of pure mucinous breast carcinoma (PMBC) according to internal echogenicity on ultrasonography (US). METHODS: Thirty-three patients with PMBC diagnosed at surgery were included in this study. Cases of PMBC were classified according to internal echogenicity on US. The imaging features on magnetic resonance (MR) imaging and clinicohistopathological characteristics were compared between the hypoechogenic and the isoechogenic to hyperechogenic groups. RESULTS: Eleven cases of PMBC (33.3%) exhibited hypoechogenicity on US, while 22 cases (66.7%) exhibited isoechogenicity or hyperechogenicity. Of the isoechogenic to hyperechogenic PMBCs, 95.5% showed a high signal on T2-weighted images, which was a significantly greater percentage than was observed for the hypoechogenic group (54.5%) (P=0.010). Of the hypoechogenic PMBCs, 63.6% showed a washout pattern in the delayed phase, which was substantially more than the result of 23.8% observed for the isoechogenic to hyperechogenic PMBCs (P=0.053). CONCLUSION: PMBCs with isoechogenicity or hyperechogenicity were more likely to show a high signal intensity on T2-weighted images than hypoechogenic PMBCs. However, other MR imaging and clinicohistopathological characteristics were not significantly different between the two groups.ope

5-Fluorouracil 내성 인체 대장암 세포주 SNU-C4 배양액에서 발견되는 단백질 중 당분해효소 증가

Thesis(doctors) --서울대학교 대학원 :협동과정 종양생물학전공,2009.8.Docto

한국인 가족성 비용종증 대장암 가계에서 MLH1유전자의 1757_1758insC 배선돌연변이의 시조(始祖) 효과에 관한 연구

Thesis(master`s)--서울대학교 대학원 :협동과정 종양생물학전공,2005.Maste

Sonographically Guided 14-Gauge Core Needle Biopsy: Medical Audit for One Year of 2013

Purpose: The objective of our study was to determine the diagnostic accuracy, underestimation rate and false negative rate of sonographically guided core needle biopsy for breast lesions. Materials and Methods: In this retrospective study, we included a total of 894 lesions from 682 patients who had undergone sonographically guided 14-gauge core needle biopsies between March 2013 and December 2013. The sonographic category of breast lesions and the pathologic results of core needle biopsies were reviewed and correlated with that of surgery or vacuum assisted biopsy, or long term (>1yr) imaging follow-up. Through this, the positive predictive value for each sonographic category, sensitivity, underestimation rate and false negative rate of core needle biopsy were evaluated. Results: A total of 894 cases, the pathologic results for the core needle biopsy were benign in 497, high-risk in 134, ductal carcinoma in situ in 44, invasive cancer in 216, other malignant tumor in 3. The positive predictive values for each sonographic category were as follows: 0.0% in category 2; 4.0% in category 3; 13.4% in category 4a; 48.9% in category 4b; 87.9% in category 4c and 96.3% in category 5. The sensitivity of core needle biopsy was 93.3% (263 of 282). The underestimation rate was 11.9% for high-risk lesion(21.1% of atypical ductal hyperplasia, 10.4% for non-atypical ductal hyperplasia) and 36.4% (16 of 44) for ductal carcinoma in situ. Of 497 benign lesions, 3 lesions were confirmed as malignancy, and the false negative rate was 0.6%. Conclusion: Sonographically guided core needle biopsy for 10 months of 2013 year in our hospital was accurate diagnostic tool for evaluating breast lesion.ope