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    ์กฐ๊ธฐ์ •์‹ ์ฆ ๋Œ€์ƒ์ž๋ฅผ ์œ„ํ•œ ์ง€์—ญ์‚ฌํšŒ๊ธฐ๋ฐ˜ ์‚ฌ๋ก€๊ด€๋ฆฌ ๊ฒฝํ—˜

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    ํ•™์œ„๋…ผ๋ฌธ (์„์‚ฌ)-- ์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› : ๊ฐ„ํ˜ธํ•™๊ณผ, 2017. 2. ์ตœํฌ์Šน.์ „ ์„ธ๊ณ„์ ์œผ๋กœ ์ •์‹ ๋ณ‘์„ ์กฐ๊ธฐ์— ๋ฐœ๊ฒฌํ•˜๊ณ  ์น˜๋ฃŒํ•˜๊ธฐ ์œ„ํ•œ ๊ด€์‹ฌ์ด ๋†’์•„์ง€๊ณ  ์žˆ๋‹ค. 2011๋…„ ์„œ์šธ์‹œ ๊ด‘์—ญ์ •์‹ ๊ฑด๊ฐ•์ฆ์ง„์„ผํ„ฐ๋Š” ์ง€์—ญ์‚ฌํšŒ ๊ธฐ๋ฐ˜์˜ ์กฐ๊ธฐ์ •์‹ ์ฆ ์‚ฌ๋ก€๊ด€๋ฆฌ ํ”„๋กœ๊ทธ๋žจ(Social Treatment for Early Psychosis Program:์ดํ•˜ STEP ํ”„๋กœ๊ทธ๋žจ)์„ ๊ฐœ๋ฐœํ•˜์˜€์ง€๋งŒ ์•„์ง๊นŒ์ง€ ๊ตญ๋‚ด์—์„œ ์กฐ๊ธฐ์ •์‹ ์ฆ์— ๋Œ€ํ•œ ์—ฐ๊ตฌ๋Š” ๋ฏธ์ง„ํ•œ ์ƒํƒœ์ด๋‹ค. ์ด์— ๋ณธ ์—ฐ๊ตฌ๋Š” STEP ํ”„๋กœ๊ทธ๋žจ์„ ์ ์šฉํ•˜๋Š” ์‚ฌ๋ก€๊ด€๋ฆฌ์ž์˜ ๊ฒฝํ—˜์„ ์งˆ์  ๋‚ด์šฉ๋ถ„์„ ๋ฐฉ๋ฒ•์œผ๋กœ ๋ถ„์„ํ•˜์—ฌ, ์ง€์—ญ์‚ฌํšŒ์—์„œ ์กฐ๊ธฐ์ •์‹ ์ฆ ๋Œ€์ƒ์ž๋ฅผ ์œ„ํ•œ ์‚ฌ๋ก€๊ด€๋ฆฌ ํ™œ์„ฑํ™” ๋ฐฉ์•ˆ์„ ๋ชจ์ƒ‰ํ•˜๊ณ  ์‹ค๋ฌด์  ๊ธฐ์ดˆ์ž๋ฃŒ๋ฅผ ๋งˆ๋ จํ•˜๊ณ ์ž ํ•œ๋‹ค. ๋ณธ ์—ฐ๊ตฌ๋Š” 2016๋…„ 7์›”๋ถ€ํ„ฐ 2016๋…„ 10์›”๊นŒ์ง€ ์„œ์šธ์‹œ ์ •์‹ ๊ฑด๊ฐ•์ฆ์ง„์„ผํ„ฐ์—์„œ 1๋…„ ์ด์ƒ ์กฐ๊ธฐ์ •์‹ ์ฆ ์‚ฌ๋ก€๊ด€๋ฆฌ๋ฅผ ๋‹ด๋‹นํ•˜๊ณ  ์žˆ๋Š” ์ •์‹ ๋ณด๊ฑด์ „๋ฌธ์š”์› 10๋ช…์„ ๋Œ€์ƒ์œผ๋กœ ์ง„ํ–‰๋˜์—ˆ๋‹ค. ๋ฉด๋‹ด ์งˆ๋ฌธ์€ ์กฐ๊ธฐ์ •์‹ ์ฆ ์‚ฌ๋ก€๊ด€๋ฆฌ์— ์˜ํ–ฅ์„ ์ฃผ๋Š” ์‚ฌ๋ก€๊ด€๋ฆฌ์ž ์š”์ธ, ๋Œ€์ƒ์ž ์š”์ธ, ๊ตฌ์กฐ์  ์š”์ธ, ๋„คํŠธ์›Œํฌ ์š”์ธ์œผ๋กœ ๊ตฌ๋ถ„ํ•˜์—ฌ ์ง„ํ–‰ํ•˜์˜€๊ณ  ์ธํ„ฐ๋ทฐ ๋‚ด์šฉ์€ ์—ฐ๊ตฌ ์ฐธ์—ฌ์ž์˜ ๋™์˜ํ•˜์— ๋…น์Œ๋˜๊ณ  ํ•„์‚ฌ๋˜์—ˆ๋‹ค. ์ฃผ์š” ์—ฐ๊ตฌ๊ฒฐ๊ณผ๋Š” ๋‹ค์Œ๊ณผ ๊ฐ™๋‹ค. STEP ์‹ค๋ฌด์ž ๊ต์œก์„ ํ†ตํ•ด ์กฐ๊ธฐ๊ฐœ์ž…์˜ ์ค‘์š”์„ฑ์„ ์ธ์‹ํ•œ ์‚ฌ๋ก€๊ด€๋ฆฌ์ž๋Š” STEP ํ”„๋กœ๊ทธ๋žจ์„ ์‹ค๋ฌด์— ์ ์šฉํ•˜๊ธฐ ์œ„ํ•ด ์ „๋ฌธ์ ์ธ ์—ญ๋Ÿ‰์„ ๊ฐœ๋ฐœํ•˜๊ณ  ๋Œ€์ƒ์ž์™€ ๋ผํฌ๋ฅผ ํ˜•์„ฑํ•˜๊ธฐ ์œ„ํ•ด ์ •์ƒํ™”(Normalization) ๊ธฐ๋ฒ•์„ ์ ์šฉํ•˜๊ณ  ์žˆ์—ˆ๋‹ค. ์ด์™€ ๊ฐ™์€ ์‚ฌ๋ก€๊ด€๋ฆฌ์ž์˜ ๋…ธ๋ ฅ์ด ์†Œ์ง„์ด ์•„๋‹Œ ์—ด์ •์œผ๋กœ ์ด์–ด์ง€๋ฉด, ์‚ฌ๋ก€๊ด€๋ฆฌ์ž๋Š” ๋Œ€์ƒ์ž์˜ ๋น ๋ฅธ ํšŒ๋ณต์„ ํ†ตํ•ด ๋ณด๋žŒ์„ ๋Š๊ผˆ๊ณ  ๋Œ€์ƒ์ž์™€ ํ•จ๊ป˜ ์‚ฌ๋ก€๊ด€๋ฆฌ์ž๋„ ์„ฑ์žฅํ•˜๋Š” ๊ฒฝํ—˜์„ ํ•˜์˜€๋‹ค. ๋Œ€์ƒ์ž ์š”์ธ์—๋Š” ์ž๋…€์˜ ์งˆ๋ณ‘์„ ์ธ์ •ํ•˜์ง€ ์•Š๋Š” ๋ถ€๋ชจ๊ฐ€ ์žฅ์• ์š”์ธ์ด ๋˜๋Š” ๋ฐ˜๋ฉด, ํ”„๋กœ๊ทธ๋žจ ๋‚ด์—์„œ ๋งŒ๋‚œ ๋™๋ฃŒ๋“ค์ด ์ •์„œ์ ์ธ ์ง€์ง€์™€ ํšŒ๋ณต ๋ชจ๋ธ์„ ์ œ๊ณตํ•˜๊ณ  ์žˆ์—ˆ๋‹ค. ๋˜ํ•œ ๋Œ€์ƒ์ž์˜ ์š•๊ตฌ์™€ ๊ธฐ๋Šฅ์ˆ˜์ค€์— ๋”ฐ๋ฅธ ์ฐจ๋ณ„์ ์ธ ์‚ฌ๋ก€๊ด€๋ฆฌ๊ฐ€ ์š”๊ตฌ๋˜์—ˆ์œผ๋ฉฐ, ์•ฝ๋ฌผ ์ค‘๋‹จ์œผ๋กœ ์ธํ•œ ์žฆ์€ ์žฌ๋ฐœ๊ณผ ๋†’์€ ์ž์‚ด์‚ฌ๊ณ ๋กœ ์ธํ•ด ์ •์‹ ๊ณผ์ ์ธ ์œ„๊ธฐ๊ฐ€ ์ž์ฃผ ๋ฐœ์ƒํ•˜๊ณ  ์žˆ์—ˆ๋‹ค. ๊ตฌ์กฐ์  ์š”์ธ์—๋Š” ์ƒ์ž„ํŒ€์žฅ์˜ ๊ด€์‹ฌ๊ณผ ์ง€์›์ด ๊ธ์ •์ ์ธ ์—ญํ• ์„ ํ•˜๊ณ  ์žˆ์—ˆ๋‹ค. ๋ฐ˜๋ฉด, ์„œ์šธ์‹œ ์ง€์—ญ์ •์‹ ๊ฑด๊ฐ•์ฆ์ง„์„ผํ„ฐ๋Š” ์ •์‹ ๋ณด๊ฑด์˜๋ฃŒ๊ธฐ๊ด€๊ณผ์˜ ํ˜‘๋ ฅ๊ด€๊ณ„์— ์–ด๋ ค์›€์„ ๊ฒฝํ—˜ํ•˜๊ณ  ์žˆ์—ˆ๊ณ , ์ง€์—ญ์‚ฌํšŒ ์กฐ๊ธฐ์ •์‹ ์ฆ ์‚ฌ์—…์˜ ์ง€์†์„ฑ๊ณผ ์ฒด๊ณ„์„ฑ์˜ ๋ถ€์กฑ์ด ํ•œ๊ณ„์ ์œผ๋กœ ์ง€์ ๋˜์—ˆ๋‹ค. ๋„คํŠธ์›Œํฌ ์š”์ธ์œผ๋กœ ์„œ์šธ์‹œ ๊ด‘์—ญ์ •์‹ ๊ฑด๊ฐ•์ฆ์ง„์„ผํ„ฐ๋Š” ์‚ฌ๋ก€๊ด€๋ฆฌ์ž์˜ ์—ญ๋Ÿ‰๊ฐ•ํ™”๋ฅผ ์œ„ํ•ด ์ „๋ฌธ์ ์ธ ๋งค๋‰ด์–ผ๊ณผ ๊ต์œก์„ ์ œ๊ณตํ•˜๊ณ  ์ง€์—ญ์‚ฌํšŒ์˜ ์‚ฌ๋ก€๊ด€๋ฆฌ ๊ธฐ๋ฐ˜์„ ๋งˆ๋ จํ•˜๊ณ  ์žˆ์—ˆ๋‹ค. ์ •๋ถ€์ฐจ์›์œผ๋กœ๋Š” ์‚ฌ๋ก€๊ด€๋ฆฌ์ž์˜ ์—ด์•…ํ•œ ์ง๋ฌดํ™˜๊ฒฝ๊ณผ ์ •์‹ ์งˆํ™˜์— ๋Œ€ํ•œ ๋Œ€์ค‘์˜ ๋ถ€์ •์ ์ธ ์ธ์‹์„ ๊ฐœ์„ ํ•˜๊ณ  ์กฐ๊ธฐ์ •์‹ ์ฆ์— ํŠนํ™”๋œ ์ •์‹ ๋ณด๊ฑด์‹œ์Šคํ…œ์„ ๊ตฌ์ถ•ํ•ด์•ผ ํ•œ๋‹ค๋Š” ํ•„์š”์„ฑ์ด ์ œ๊ธฐ๋˜์—ˆ๋‹ค. ๋ณธ ์—ฐ๊ตฌ๋Š” ์ง€์—ญ์‚ฌํšŒ์—์„œ ์กฐ๊ธฐ์ •์‹ ์ฆ ์‚ฌ๋ก€๊ด€๋ฆฌ์ž์˜ ๊ฒฝํ—˜์„ 4๊ฐ€์ง€ ์š”์ธ์„ ํ†ตํ•ด ํ™•์ธํ•˜์˜€๊ณ , ๊ฐ ์š”์ธ์— ๋Œ€ํ•œ ์ดํ•ด๋ฅผ ์ œ๊ณตํ•˜์˜€๋‹ค. ์ด๋Š” ์ง€์—ญ์‚ฌํšŒ์—์„œ STEP ํ”„๋กœ๊ทธ๋žจ์ด ํ™œ์„ฑํ™”๋˜๊ณ  ์กฐ๊ธฐ์ •์‹ ์ฆ ๋Œ€์ƒ์ž๋ฅผ ์œ„ํ•œ ํšจ๊ณผ์ ์ธ ์‚ฌ๋ก€๊ด€๋ฆฌ๋ฅผ ์ œ๊ณตํ•  ์ˆ˜ ์žˆ๋Š” ๊ทผ๊ฑฐ๊ฐ€ ๋  ๊ฒƒ์ด๋‹ค. ์ฃผ์š”์–ด: ์‚ฌ๋ก€๊ด€๋ฆฌ, ์กฐ๊ธฐ์ •์‹ ์ฆ, ์ง€์—ญ์‚ฌํšŒ ํ•™ ๋ฒˆ: 2012-20432โ… . ์„œ๋ก  1 1.1 ์—ฐ๊ตฌ์˜ ํ•„์š”์„ฑ 1 2.1 ์—ฐ๊ตฌ์˜ ๋ชฉ์  4 3.1 ์šฉ์–ด์˜ ์ •์˜ 4 โ…ก. ๋ฌธํ—Œ๊ณ ์ฐฐ 5 1.1 ์กฐ๊ธฐ์ •์‹ ์ฆ 5 1.1.1 ์กฐ๊ธฐ๊ฐœ์ž… 5 1.1.2 ๋ฏธ์น˜๋ฃŒ ๊ธฐ๊ฐ„(Duration of Untreated Psychosis : DUP) 7 2.1 ์‚ฌ๋ก€๊ด€๋ฆฌ 9 2.1.1 ์‚ฌ๋ก€๊ด€๋ฆฌ์˜ ๊ฐœ๋… 9 2.1.2 ์‚ฌ๋ก€๊ด€๋ฆฌ ๋ชจ๋ธ 10 2.1.3 ์‚ฌ๋ก€๊ด€๋ฆฌ ๊ตฌ์„ฑ์š”์†Œ 13 2.1.4.์ •์‹ ๊ฑด๊ฐ•์ฆ์ง„์„ผํ„ฐ์—์„œ์˜ ์‚ฌ๋ก€๊ด€๋ฆฌ 14 3.1 ์กฐ๊ธฐ๊ฐœ์ž… ์„œ๋น„์Šค 18 3.1.1.ํ•ด์™ธ ์กฐ๊ธฐ๊ฐœ์ž… ์„œ๋น„์Šค 19 3.1.2 ๊ตญ๋‚ด ์กฐ๊ธฐ๊ฐœ์ž… ์„œ๋น„์Šค 20 3.1.3 STEP(Social Treatment for Early Psychosis Program) 22 โ…ข. ์—ฐ๊ตฌ๋ฐฉ๋ฒ• 26 1.1 ์—ฐ๊ตฌ ์ฐธ์—ฌ์ž ์„ ์ • 26 2.1 ์ž๋ฃŒ ์ˆ˜์ง‘ ๋ฐฉ๋ฒ• 26 3.1 ์œค๋ฆฌ์  ๊ณ ๋ ค 28 4.1 ์ž๋ฃŒ ๋ถ„์„ ๋ฐฉ๋ฒ• 28 โ…ฃ. ์—ฐ๊ตฌ๊ฒฐ๊ณผ 31 1.1 ์—ฐ๊ตฌ ์ฐธ์—ฌ์ž์˜ ์ผ๋ฐ˜์  ํŠน์„ฑ 31 2.1 ์กฐ๊ธฐ์ •์‹ ์ฆ ์‚ฌ๋ก€๊ด€๋ฆฌ ๊ฒฝํ—˜๊ณผ ๊ด€๋ จ๋œ ๋ฒ”์ฃผ 32 2.1.1.์‚ฌ๋ก€๊ด€๋ฆฌ์ž ์š”์ธ 33 2.1.2 ๋Œ€์ƒ์ž ์š”์ธ 38 2.1.3 ๊ตฌ์กฐ์  ์š”์ธ 42 2.1.4 ๋„คํŠธ์›Œํฌ ์š”์ธ 45 โ…ค. ๋…ผ์˜ 52 1.1 ์‚ฌ๋ก€๊ด€๋ฆฌ์ž ์š”์ธ 52 2.1 ๋Œ€์ƒ์ž ์š”์ธ 56 3.1 ๊ตฌ์กฐ์  ์š”์ธ 61 4.1 ๋„คํŠธ์›Œํฌ ์š”์ธ 65 โ…ฅ. ๊ฒฐ๋ก  ๋ฐ ์ œ์–ธ 76 ์ฐธ๊ณ ๋ฌธํ—Œ 79 ๋ถ€๋ก 96 Abstract 98Maste

    Changing trends of infective endocarditis according to the change in health care system in Korea

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    Background: In July 2000, there was a dramatic change in Korean health care system with the medical reform, the separation system of pharmacies and prescriptions. Before then, patients could easily get antibiotics without doctorsโ€™ prescriptions. Since the symptoms and signs of infective endocarditis are very nonspecific, prior self treatment with antibiotics before admission was common. This study was performed to determine the changing trends of infective endocarditis according to the change in health care system. Methods: One hundred eighty eight patients from 8 different medical institutions were included. Medical records were reviewed retrospectively for each patient who was diagnosed as infective endocarditis by Modified Duke criteria. Patients were separated into two different groups (Group I : patients diagnosed before July 2000, Group II : patients diagnosed after November 2000). Clinical characteristics, blood culture positivity, and in-hospital mortality were compared. Results: There was no difference in clinical manifestation between two groups other than malaise. Blood culture positivity was 57.4% in group I and 71.1% in group II. Blood culture positivity was significantly higher in group II (p=0.038). In-hospital mortality tends to be lower in group II, which was 22.3% in group I and 12.9% in group II (p=0.066). The relationship between higher blood culture positivity and lower in-hospital mortality couldnโ€™t be clarified. Conclusion: There was an increase in blood culture positivity and a tendency to decrease in in-hospital mortality after July, 2000, possibly due to health care reform. This, to my knowledge, is the first effort to investigate the changing trends of an actual clinical disease according to the change in health care system.ope

    Epidemiology of HIV/AIDS in East Asia

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    Background:Recent predictions of catastrophic epidemic surge of HIV infection in East Asia concern experts and governmental organizations. As in many other areas, countries in East Asia show diversities in their HIV epidemics, both geographically and temporally. However, they have similar regional, cultural and racial characteristics which allow them to have certain common factors. Having a clear picture of the current extent and feature of HIV/AIDS in this region is a very difficult task largely due to the fast pacing of expending epidemic and difficulty in data-sharing among countries in the region. Hence, we decided to study the epidemiologic feature of HIV/AIDS in East Asia through East Asia Network on HIV (EAN-HIV). Materials and Methods:The epidemiological patterns of HIV/AIDS in East Asian countries were investigated by collecting data through EAN-HIV. Results:The HIV/AIDS epidemic in East Asia started relatively late at mid 1980s. Since then, the number of newly infected HIV/AIDS cases has been steadily increasing with stiffer escalation in recent years. In China and Taiwan, IDU plays an important part in the swiftly growing HIV epidemics; however, in other regions like Korea, Japan, and Hong Kong, MSM (men who have sex with men) seems to be more of a problem. The major subtypes of HIV in East Asia are subtype B, C, and CRF01_AE, and rapidly evolving circulating recombinant forms (CRF) between subtypes such as CRF07_BC give dynamic change to the current status. Conclusion:The incidence of HIV/AIDS is rapidly increasing in East Asia. The epidemic pattern has undergone dynamic changes over time. China seems to be the leading source of HIV/AIDS epidemic in East Asia due to its large population and rapidly growing epidemics.ope

    Ovarian Cystadenofibroma in a Patient with Familial Adenomatous Polyposis

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    Familial adenomatous polyposis (FAP) is a hereditary disease characterized by the appearance of numerous polyps in the large bowel with a high potential for malignant transformation unless untreated. A variety of extracolonic manifestations were reported such as osteoma, epidermoid cyst, desmoid tumor, gastroduodenal polyps, small bowel tumor, congenital hypertrophy of the retinal pigment epithelium, hepatobiliary tumor, thyroid tumor, and tumor of 12 the central nervous system. However, the ovarian involvement of FAP as an extracolonic manifestation was very rare and there have been only few reports. We experienced a rare case of ovarian cystadenofibroma in a patient with FAP as an extracolonic manifestation. We also found colon cancer with multiple hepatic metastasis initially manifested as intestinal obstruction in the same patient. Surgical treatment and subsequent chemotherapy for colon cancer and intraoperative radiofrequency ablation of hepatic metastasis were 15 performed.ope

    Viral shedding of 2009 pandemic H1N1 and evaluation of quarantine recommendations

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    Public health authorities recommend that isolation precautions for influenza should be continued for 7 days after illness onset or until 24 h after the resolution of symptoms, whichever event lasts longer. However, little data are available regarding the duration of isolation for patients with 2009 pandemic H1N1 (pH1N1). We recruited patients with confirmed pH1N1 virus infection at a 2,000-bed tertiary care center. Influenza viral loads from oropharyngeal swab specimens were serially determined by reverse transcriptase quantitative polymerase chain reaction every other day, and the risk factors for prolonged viral shedding were investigated. To evaluate the current recommendations for isolation precautions, we measured the intervals between symptom onset and the last viral RNA detection, and that between the last viral RNA detection and the point at which the patient was symptom-free for 24 h. From November 2009 to January 2010, 26 patients were enrolled, and viral RNA was detected in more than half of the eligible patients (10 of 19, 52.6%) for โ‰ฅ7 days after symptom onset. While evaluating the policy for lifting quarantine, we found that viral RNA was detected in 4 of 15 patients (26.7%) beyond the recommended duration of isolation. In conclusion, viral RNA was detected in a substantial proportion of hospitalized patients even when they fulfilled the recommended conditions for lifting quarantine, and we believe that more prudence is required in this aspect.ope

    A Case of Brucellar Spondylitis with Multiple Spine Involvement

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    Brucellosis, a zoonosis with world wide distribution, is a systemic infection that affects several organs and has protean presentation. Although spondylitis is universally the most common complication of brucellosis and difficult to treat, there is no consensus on the preferred combination of antibiotics use. The authors report a case of a 58-year-old male patient with brucellar spondylitis involving several vertebrae. Diagnosis was made by positive blood culture and magnetic resonance imaging. The authors use a combination method of doxycycline, ciprofloxacin and streptomycin for a period of 3 months. The systemic symptoms were improved after treatment.ope

    Clinical features of re-emerging hepatitis A: an analysis of patients hospitalized during an urban epidemic in Korea.

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    From April 2008 to November 2008, many cases of hepatitis A were reported in Seoul and Gyeonggi Province in Korea. Furthermore, the rate of severe or fulminant hepatitis have significantly increased during the latest epidemic (13.4% vs. 5.2%, p=0.044). Therefore, widespread use of vaccine is warranted to reduce the burden of hepatitis A in Korea.ope

    Recurrent Coccidioidomycosis Manifesting as Osteomyelitis in Korea

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    Coccidioidomycosis is a fungal infection that results from inhaling the airborne arthroconidia of the Coccidioides species. It is an endemic disease in the southwest part of North America and rarely diagnosed in Korea. As tourism to endemic areas and the number of immunocompromised patients have been increasing, the incidence of this infection has increased in non-endemic areas. Treatment is usually successful with antifungal agents; however, recurrence is common. It is difficult to decide when to discontinue the antifungal treatment especially in non-endemic areas where doctors are not familiar with the disease. We report a case of recurrent coccidioidomycosis manifesting as osteomyelitis after the treatment of the patient for disseminated coccidioidal infection. The complement fixation test was a useful tool for the assessment of patient response and to evaluate suspected recurrenceope

    Prevalence and Clinical Characteristics of Pulmonary Arterial Hypertension in Human Immunodeficiency Virus-Infected Patients

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    Background/Aims: Human immunodeficiency virus-associated pulmonary arterial hypertension (HIV-PAH) is a complication of HIV infection. Due to improvements in HIV survival rates following the introduction of highly active antiretroviral therapy, HIV-PAH has become an important cause of HIV-related morbidity. Thus, the objective of this study was to explore the prevalence and characteristics of HIV-PAH. Methods: Ninety-two patients were enrolled in the study from March to August 2010. We investigated clinical characteristics and performed echocardiography. HIV-PAH was defined as having a mean pulmonary arterial pressure (mPAP)โ‰ฅ25 mmHg based on Mahan`s equation, without lung disease or heart disease. The HIV-PAH-possible group was defined as having a tricuspid regurgitation velocity (TRV) of 2.9-3.4 m/s and a pulmonary arterial systolic pressure (PASP) of 37-50 mmHg. Results: Fifteen patients (16.3%) met the criteria of HIV-PAH based on mPAP. With respect to TRV, six patients met the criteria of the HIV-PAH-possible group. Based on the criteria of mPAP, the duration of HIV infection was not different with or without HIV-PAH. HIV RNA titers and CD4 T cell counts tended to be higher in HIV-PAH patients (8,607ยฑ11 vs. 1,067ยฑ64 copies/mL, p=0.371; 471ยฑ148 vs. 499ยฑ252 cells/mm3, p=0.680, respectively). Echocardiographic indices of the right ventricle were significantly deteriorated in the HIV-PAH group as compared with the non-HIV-PAH group (TASPE: 20.52 vs. 23.2, p=0.001; Tei index: 0.42 vs. 0.39, p=0.037). In a multivariate regression analysis, HIV activity factors (HIV duration, HIV RNA titer, and CD4 cell count) were not associated with echocardiographic indices of PAH (mPAP, PASP, and pulmonary vascular resistance). Conclusions: In this study, the prevalence of HIV-PAH was comparable to that of previous studies.ope

    Prognosis Factors of Clostridium difficile Associated Diarrhea

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    Background:Clostridium difficile associated diarrhea (CDAD) has a wide range of clinical manifestations. The prognostic factors of CDAD are not fully understood. Materialsand Methods:A retrospective cohort study of 115 patients with CDAD from Aug. 2002 to Dec. 2003 was conducted to evaluate prognostic factors of CDAD. Bacteriologic factors were determined by detecting the binary toxin gene, tcd A, tcd A rep and tcd B gene. Poor prognosis was defined as diarrhea more than 10 days even with classic treatment, recurrence, death, and moribund discharge. Results:Approximately 79% of isolated strains were toxin A+/B+ strains and 21% were toxin A-/B+ strains. There was no difference in prognosis between toxin A+ and toxin A- strains. 39 (33.9%) cases showed poor prognosis and 76 (66.1%) cases showed good prognosis. Univariate analyses revealed that the poor prognostic factors were old age over 70 years old, male, the number of antibiotics used after onset of symptom, the administration of carbapenems, aminoglycosides, glycopeptides after onset of symptom, history of DM and stroke, and high Charlson comorbidity index. Multiple logistic regression analysis identified old age over 70 years old (odds ratio=3.378, P=0.009) and the administration of carbapenems after onset of symptom (odds ratio 7.210, P<0.001) as the independent poor prognostic factors. Conclusion:Old age over 70 and the administration of carbapenems after onset of symptom were the poor prognostic factors for CDAD caused by none-binary toxin producing strains.ope
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