전처리후 웨이블릿 기반에서의 선형·비선형 복합 디노이징

Thesis (master`s)--서울대학교 대학원 :전기·컴퓨터공학부,2002.Maste

Expression of insertion-truncated form of CD99 molecule in human brain and neural precursor cell lines during development

학위논문(박사)--서울대학교 대학원 :의학과 병리학전공,1999.Docto

Improved thermal stability of poly(glycidyl nitrate) by end group modification

학위논문(석사) - 한국과학기술원 : 신소재공학과, 1997.8, [ vi, 57 p. ]한국과학기술원 : 신소재공학과

Developing korean bancassurance model through european and american banacassurance case study and literature review

학위논문(석사) - 한국과학기술원 : 경영정보전공, 2004.2, [ v, 77 p. ]한국과학기술원 : 경영정보전공

Suggestions for Improving South Korea's Fall Accidents Prevention Technology in the Construction Industry: Focused on Analyzing Laws and Programs of the United States

Since the enactment of the Occupational Safety and Health Act in 1981, the Korea Occupational Safety and Health Agency has endeavored to prevent fall accidents in the construction industry. However, many fatalities still occur in the South Korean construction industry. Meanwhile, the United States improved various systems and conducted studies to prevent fall accidents, significantly reducing such occurrences in the construction industry. The objective of this study is to present improvements to South Korea's fall prevention technology by analyzing the laws and programs of the United States. To achieve this, this study has analyzed the United States' fall prevention technology and derived improvements applicable in South Korea through an expert opinion survey. This study suggests to (1) set the height standard of a fall accident to 2 m, (2) adopt an active fall prevention system, (3) create a map of fallen fatalities, and (4) employ safety experts to support foreign workers. In the future, the results of this study are expected to be used as basic data for policies and programs related to fall accidents in the construction industry

Expression of the immune checkpoint molecule V-set immunoglobulin domain-containing 4 is associated with poor prognosis in patients with advanced gastric cancer

Abstract Background: Recent clinical studies on immune checkpoint (IC) inhibitors in the context of advanced gastric cancer (AGC) have failed to show significant survival benefits but have suggested the possible role of IC inhibitors in anti-AGC immunity. Considering the low efficacy of targeted drugs in AGC, there is an urgent need for the discovery of new targets for the development of immunotherapeutics and prognostic markers for patient selection. This study aimed to investigate the expression of a new IC molecule, V-set Ig domain-containing 4 (VSIG4), and its clinical significance in AGC and other major cancers. Methods: We analyzed the expression of VSIG4 and its correlation with survival in various carcinomas, including 882 surgically resected samples from patients with stage II-III AGC (two academic hospitals). Results: VSIG4 positivity in AGC was significantly associated with overall survival (OS; Hazard ratio (HR) = 2.661, 95% confidence interval [CI] = 2.012-3.519, P < 0.001) and event-free survival (HR = 2.8, 95% CI = 2.18-3.72, P < 0.001). These findings were successfully validated in independent cohorts. VSIG4 expression was also significantly correlated with low intratumoral CD8 + T-cell infiltration (CD8i) (P = 0.029) and high Foxp3 + /CD8i ratio (P = 0.026), which is consistent with the previously reported immunological function of VSIG4. However, VSIG4 expression was not associated with survival in other cancers (colon, P = 0.459; lung, P = 0.275; kidney, P = 0.121; breast, P = 0.147). Conclusion: Our results suggest that VSIG4 is an independent prognostic factor in AGC and also implies that VSIG4 is a second-tier IC molecule in AGC, thus, providing an important basis for the development of gastric cancer-specific immunotherapeutics. Keywords: Advanced gastric cancer; Immune checkpoint molecule; Immunotherapy; Tumor microenvironment; V-set Ig domain-containing 4

Upward trend in follicular lymphoma among the Korean population: 10-year experience at a large tertiary institution

Background: Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma (NHL) in Western countries. However, it is relatively rare in Asia. This study examined epidemiologic characteristics of FL in South Korea, with an emphasis on recent trends of increase in cases. Methods: We retrospectively examined 239 cases of newly diagnosed FL at a large tertiary institution in Korea (Asan Medical Center, Seoul, Republic of Korea) between 2008 and 2017. Age-adjusted incidence rates and clinicopathological variables were analyzed, and joinpoint regression analysis was used to identify the changes. Results: The age-adjusted incidence of FL significantly increased during the study period (p = .034), and the ratio of (relative incidence) patients with FL to patients with NHL increased from 4.28% to 9.35% in the same period. Over the 10-year study assessment duration, the proportion of patients with stage III/IV FL (p = .035) and expression of BCL2 (p = .022) or BCL6 (p = .039) significantly increased. From 2013?2017, the proportion of patients with highrisk Follicular Lymphoma International Prognostic Index (FLIPI) score increased (21.5% to 28.7%), whereas that of low-risk FLIPI decreased (55.4% to 38.6%), although those results were not statistically significant (p = .066). Conclusions: We found an increasing incidence of FL, with a disproportionate increase in the incidence of high-stage disease and recent changes in the clinicopathologic features of the Korean patient population