Target gene prediction of human microRNAs from the Rfam database by in silico analysis

Thesis(master`s)--서울대학교 대학원 :협동과정 생물정보학전공,2004.Maste

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Thesis(doctors) --서울대학교 대학원 :협동과정 생물정보학전공,2008.8.Docto

Network Comparison of Inflammation in Colorectal Cancer and Alzheimer’s Disease

Recently, a large clinical study revealed an inverse correlation of individual risk of cancer versus Alzheimer’s disease (AD). However, no explanation exists for this anticorrelation at the molecular level; however, inflammation is crucial to the pathogenesis of both diseases, necessitating a need to understand differing signaling usage during inflammatory responses distinct to both diseases. Using a subpathway analysis approach, we identified numerous well-known and previously unknown pathways enriched in datasets from both diseases. Here, we present the quantitative importance of the inflammatory response in the two disease pathologies and summarize signal transduction pathways common to both diseases that are affected by inflammation