100 research outputs found

    κ°€μ‘±μƒν™œμ˜ κ°œμΈν™”μ™€ μΉœλ°€μ„±μ˜ νƒˆμ œλ„ν™” - 이성애 μ²­λ…„ 동거λ₯Ό μ€‘μ‹¬μœΌλ‘œ

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    ν•™μœ„λ…Όλ¬Έ(석사) -- μ„œμšΈλŒ€ν•™κ΅λŒ€ν•™μ› : μ‚¬νšŒκ³Όν•™λŒ€ν•™ μ‚¬νšŒν•™κ³Ό, 2022.2. 배은경.λ³Έ μ—°κ΅¬λŠ” μ—°μ• , 결혼, μΆœμ‚°μ„ λͺ¨λ‘ ν¬κΈ°ν•˜μ˜€λ‹€λŠ” Nν¬μ„ΈλŒ€ 담둠이 μ²­λ…„λ“€μ—κ²Œ μ§‘μ€‘λ˜κ³  μžˆλŠ” ν˜„μ‹€μ—μ„œ μΉœλ°€μ„±μ„ μœ μ§€ν•˜λ €λŠ” λ‹€μ–‘ν•œ ν˜•νƒœμ˜ κ°€μ‘± κ²½ν—˜μ˜ μ—¬λŸ¬ μΈ΅μœ„κ°€ 획일적으둜 ν•΄μ„λ˜κ³  μžˆλ‹€λŠ” λ¬Έμ œμ œκΈ°μ—μ„œ μΆœλ°œν•œλ‹€. λ§Žμ€ 청년듀이 경제 μœ„κΈ° 이후 μ·¨μ—…λ‚œ, μ£Όκ±°λ‚œ λ“±μ˜ 어렀움을 κ²ͺκ³  μžˆλŠ” 것은 μ‚¬μ‹€μ΄μ§€λ§Œ μΉœλ°€μ„±μ˜ μ˜μ—­μ΄ λͺ¨λ‘ λ¬΄λ„ˆμ‘Œλ‹€κ³  ν•˜κΈ°μ—λŠ” μΉœλ°€μ„±κ³Ό μ„ΉμŠˆμ–Όλ¦¬ν‹°λ₯Ό λ°”νƒ•μœΌλ‘œ ν•œ 동거와 같은 κ°€μ‘± ꡬ성은 μ—¬μ „νžˆ μ‘΄μž¬ν•˜κ³  μžˆλ‹€. ν•˜μ§€λ§Œ μ‹€μ œ λ‹€μ–‘ν•œ 가쑱에 λŒ€ν•œ 상상이 μ–Όλ§ˆλ‚˜ ꡬ체적으둜 λ˜μ—ˆλŠλƒ ν–ˆμ„ λ•Œ μ‚¬νšŒμ  인식 외에도 ν˜„μž¬μ˜ λ²•μ²΄μ œλŠ” 이λ₯Ό λ°˜μ˜ν•  λ§Œν•œ μΆ©λΆ„ν•œ 질적 담둠을 ν˜•μ„±ν•˜μ§€ λͺ»ν•˜κ³  μžˆλ‹€. 무엇보닀 κ°œμΈμ€ μ‚¬νšŒμ—μ„œ ν˜Όμžμ„œλ§Œ μƒν™œμ„ μ˜μœ„ν•  수 μ—†μœΌλ©° λˆ„κ΅°κ°€μ™€ λŒλ΄„κ³Ό λΆ€μ–‘μ˜ μ±…μž„μ„ ν•¨κ»˜ ν•΄μ•Ό ν•˜λŠ” μ‘΄μž¬λ‹€. 이성애적 κ΄€κ³„μ—μ„œ λ™κ±°λŠ” κ·ΈλŸ¬ν•œ λŒλ΄„μ˜ 문제λ₯Ό ν•¨κ»˜ ν•΄κ²°ν•˜λ©° 심리적 μ•ˆμ •κ°μ„ ν˜•μ„±ν•  뿐 μ•„λ‹ˆλΌ μ‚¬νšŒμ  μ§ˆμ„œμ— κ΄€ν•œ 생각, μ •μΉ˜μ  λ³€ν™”κΉŒμ§€ μ΄λŒμ–΄λ‚΄λŠ” κ²½ν—˜μ΄ 되고 있으며 μ΄λŠ” 청년듀이 μΉœλ°€μ„±μ„ λ‚˜λ¦„μ˜ λ°©μ‹μœΌλ‘œ μœ μ§€ν•˜κΈ° μœ„ν•œ μƒˆλ‘œμš΄ ν†΅λ‘œκ°€ 되고 μžˆλ‹€. κ·Έ λ°°κ²½μ—λŠ” κ°€μ‘± κ΅¬μ„±μ˜ κ·ΌλŒ€μ  ν˜•νƒœκ°€ μ•„λ‹Œ μƒˆλ‘œμš΄ μΉœλ°€μ„±μ˜ 방식이 μΆ”κ΅¬λ˜λŠ” κ°œμΈν™”λΌλŠ” 흐름이 자리작고 μžˆλŠ”λ°, μ΄λŠ” κ°€μ‘±μƒν™œμ˜ κ°œμΈν™”μ™€ μΉœλ°€μ„±μ˜ νƒˆμ œλ„ν™”λΌλŠ” μƒˆλ‘œμš΄ μΉœλ°€μ„±μ˜ 방식을 μΆ”κ΅¬ν•˜κ²Œ λ§Œλ“€μ—ˆλ‹€. μ—¬κΈ°μ„œ κ°œμΈν™”λž€ 개인의 μΌλŒ€κΈ°κ°€ λ…Έλ™μ‹œμž₯을 μ€‘μ‹¬μœΌλ‘œ κ³„νšλ˜κ³ , μœ μ—°ν•œ '이동성'을 μš”κ΅¬λ°›κ³  κ°€λΆ€μž₯적 κ°€μΉ˜μ— κΈ°μ΄ˆν•œ κ·ΌλŒ€μ  κ°€μ‘± κ·œλ²”μ„ μœ μ§€ν•˜κΈ° μ–΄λ ΅κ²Œ 된 μ‚¬νšŒμ  λ³€ν™”λ₯Ό μ˜λ―Έν•œλ‹€. λ”°λΌμ„œ λ³Έ μ—°κ΅¬λŠ” μΉœλ°€μ„± μœ μ§€λ₯Ό μœ„ν•œ 쑰건을 주둜 경제적 μ–΄λ €μ›€μœΌλ‘œ μΉ˜ν™˜ν•΄λ²„λ¦¬λŠ” μ°©μ‹œν˜„μƒμ„ κ΅μ •ν•˜κΈ° μœ„ν•΄ 20~30λŒ€ μ²­λ…„λ“€μ˜ μ‹€μ œ 동거 계기, κ²½ν—˜, 동거λ₯Ό 톡해 μ–»κ²Œ λ˜λŠ” 결혼과 동거에 λŒ€ν•œ 인식을 μ‹¬μΈ΅λ©΄λ‹΄ν•˜μ—¬ μ΄λ“€μ˜ κ°€μ‘±μƒν™œμ„ κ°œμΈν™” 이둠을 톡해 λΆ„μ„ν•˜κ³ μž ν•œλ‹€. 이에 λ”°λ₯Έ λ³Έ μ—°κ΅¬μ˜ λ‚΄μš© 및 κ²°κ³ΌλŠ” λ‹€μŒκ³Ό κ°™λ‹€. 첫째, μ—°κ΅¬μ°Έμ—¬μžμ˜ 동거 κ³„κΈ°λŠ” λͺ¨λ‘ β€˜κ·Έλƒ₯ μžμ—°μŠ€λŸ½κ²Œβ€™ μ‹œμž‘λœ κ²ƒμœΌλ‘œ κ·Έ μ•ˆμ—μ„œ μ—°κ΅¬μ°Έμ—¬μžλ“€μ€ ν˜„μ‹€μ  λ¬Έμ œλ“€κ³Ό κ°ˆλ“±μ„ κ²ͺ으며 μΉœλ°€μ„±μ— κ΄€ν•œ μƒˆλ‘œμš΄ μ§ˆμ„œλ₯Ό κ΅¬μ„±ν•˜κ³  μžˆμ—ˆλ‹€. 이듀은 κ°œμΈν™”λœ μ‚Άμ˜ 쑰건듀 μ†μ—μ„œλ„ 두 μ‚¬λžŒμ΄ ν•¨κ»˜ μΉœλ°€μ„±μ„ μœ μ§€ν•΄ λ‚˜κ°€κΈ° μœ„ν•œ μ„±μ°°κ³Ό ν–‰λ™μ‘°μœ¨μ„ ν•΄ λ‚˜κ°€κ³  μžˆμ—ˆλ‹€. 이λ₯Ό 톡해 μ—°κ΅¬μ°Έμ—¬μžλ“€μ€ 인격적 μ–΄λ₯Έλ¨μ„ μŠ΅λ“ν•˜κ³  μžˆμ—ˆμœΌλ©°, λ‚¨μ„±λ“€μ˜ 경우 μ—¬μ„±λ“€μ˜ 삢에 κ΄€ν•œ 이해도λ₯Ό λ†’μ΄λŠ” 계기가 λ˜κΈ°λ„ ν–ˆλ‹€. λ‘˜μ§Έ, μ—°κ΅¬μ°Έμ—¬μžλ“€μ˜ λ™κ±°λŠ” 전톡적 κ°€μ‘±μ£Όμ˜λ‘œλΆ€ν„° λ²—μ–΄λ‚˜κ³ μž ν•˜λŠ” νƒˆμ œλ„ν™” ν˜„μƒμœΌλ‘œ λ³Ό 수 μžˆλ‹€. λ³Έ μ—°κ΅¬μ—μ„œ 전톡적 κ°€μ‘±μ£Όμ˜λž€ μœ κ΅μ γ†κΆŒμœ„μ£Όμ˜μ γ†κ°€λΆ€μž₯적인 가쑱ꡬ성을 μ˜λ―Έν•˜λŠ” κ²ƒμœΌλ‘œ, μ—°κ΅¬μ°Έμ—¬μžλ“€μ€ λͺ¨λ‘ μ–‘κ°€ 가쑱이 삢에 κ°œμž…ν•˜κ²Œ λ˜λŠ” κ²°ν˜Όμ— κ΄€ν•œ 큰 뢀담감을 μ•ˆκ³  μžˆμ—ˆλ‹€. ν•œκ΅­μ—μ„œ β€˜κ²°ν˜Όμ΄ μ•„λ‹Œβ€™ λ™κ±°λŠ” μ—¬μ „νžˆ μ‚¬νšŒμ  낙인 문제λ₯Ό κ²ͺ게 ν–ˆμ§€λ§Œ, μ΄λŸ¬ν•œ 뢀정적 μš”μ†Œμ—λ„ λΆˆκ΅¬ν•˜κ³  각자의 μƒν™œμ„ 자율적으둜 μ‘°μ •ν•˜κ³  κ°μžκ°€ ν‰λ“±ν•œ κ΄€κ³„μ—μ„œ 삢을 μ˜μœ„ν•΄ λ‚˜κ°ˆ 수 μžˆλŠ” 동거 μΉœλ°€μ„±λ§Œμ˜ νŠΉμ§•μ€ 이듀이 관계λ₯Ό 지속해 λ‚˜κ°ˆ 수 있게 ν–ˆλ‹€. νŠΉκΈ°ν•  λ§Œν•œ 지점은 μ΄λ“€μ˜ 관계가 λ‚˜λ¦„μ˜ 결속λ ₯을 가지고 μžˆλ‹€λŠ” 점이닀. μ—°κ΅¬μ°Έμ—¬μžλ“€μ€ 동거 κ³Όμ •μ—μ„œ 헀어짐을 μ—Όλ‘ν•˜κΈ°λ³΄λ‹€ κ΄€κ³„μ˜ μ˜μ†μ„±μ„ κΈ°λŒ€ν•˜λ©° 동거λ₯Ό μ‹œμž‘ν–ˆμœΌλ©°, 동거 μ»€ν”Œ 특유의 κΈ΄μž₯감을 ν˜•μ„±ν•΄ λ‚˜κ°€κ³  μžˆμ—ˆλ‹€. 헀어짐이 μ‰¬μšΈ κ²ƒμ΄λΌλŠ” 기쑴의 인식과 달리 동거 κ΄€κ³„λŠ” μ‹€μ§ˆμ μΈ ꡬ속λ ₯을 μƒν˜Έ ν˜•μ„±ν•˜κ³  μžˆμ—ˆλ‹€. μ…‹μ§Έ, λ™κ±°λŠ” μ—°κ΅¬μ°Έμ—¬μžλ“€μ—κ²Œ λŒ€μ•ˆμ  μƒμ• κ³Όμ •μœΌλ‘œμ„œ λ™κ±°μ˜ 지속 κ°€λŠ₯성을 확보해 μ£Όκ³  μžˆμ—ˆλ‹€. μ΄λ“€μ—κ²Œ κ°€μ‘±μ˜ μ˜λ―ΈλŠ” 법λ₯ μ  ν…Œλ‘λ¦¬ 보닀 λŒ€μ²΄μ μœΌλ‘œ μΉœλ°€μ„± κ·Έ 자체둜 μΈμ‹λ˜μ—ˆμœΌλ©° μ΄λŠ” 결혼 κ³„νš 여뢀와 관계없이 μ•žμœΌλ‘œμ˜ μ‚Άμ˜ 기쀀점을 μ„Έμš°κ³  μ±…μž„κ°μ„ κ°–κ²Œ ν•˜λŠ” 주체적 λ™κΈ°λ‘œ μž‘μš©ν–ˆλ‹€. μ΄λŸ¬ν•œ λ³€ν™”λŠ” 개인의 독립성이 μ¦λŒ€λœ μƒν™©μ—μ„œ μΉœλ°€μ„±μ„ μœ μ§€ν•˜κΈ° μœ„ν•œ μƒˆλ‘œμš΄ ν˜•νƒœμ˜ 생애과정을 κ³„μ†ν•΄μ„œ λͺ¨μƒ‰ν•˜κ²Œ ν•˜λŠ” ν†΅λ‘œλ₯Ό λ§Œλ“€μ–΄μ£Όμ—ˆλ‹€. λ³Έ μ—°κ΅¬λŠ” 동거에 κ΄€ν•œ 질적 연ꡬ가 λΆ€μ‘±ν•œ ν˜„μ‹€μ—μ„œ κ΄„ν˜Έ 속에 λ“€μ–΄κ°€ μžˆλŠ” μ²­λ…„λ“€μ˜ μ‹€μ œ μΉœλ°€μ„±κ³Ό κ΄€λ ¨ν•œ κ²½ν—˜λ“€μ„ λ“œλŸ¬λ‚΄κ³ μž ν•˜μ˜€κ³ , κ°œμΈν™”μ™€ μ‹ μžμœ μ£Όμ˜μ  λ³€ν™” μ†μ—μ„œ μΉœλ°€μ„±μ„ ν¬κΈ°ν•˜μ§€ μ•ŠλŠ” 사둀듀을 톡해 기쑴의 3ν¬μ„ΈλŒ€ λ‹΄λ‘  기각을 μ‹œλ„ν–ˆλ‹€. λ˜ν•œ κ°œμΈν™”λΌλŠ” μ‚¬νšŒμ  λ³€ν™” μ†μ—μ„œ 동거 μ—°κ΅¬λŠ” κ°€μ‘±μƒν™œμ— λŒ€ν•œ λ‹€μ–‘ν•œ 상상λ ₯을 κ°–κ²Œ ν•΄μ£ΌλŠ” μ‹œμž‘μ μ΄ 될 수 μžˆλ‹€λŠ” μ μ—μ„œ κ·Έ 의의λ₯Ό 찾을 수 μžˆλ‹€.제 1 μž₯ μ„œ λ‘  1 제 1 절 문제제기 1 제 2 절 선행연ꡬ κ²€ν†  7 제 3 절 이둠적 μžμ› 22 제 4 절 연ꡬ λͺ©μ  32 제 5 절 연ꡬ 방법 34 제 2 μž₯ λ™κ±°μ—μ„œ κ²½ν—˜ν•˜λŠ” μΉœλ°€μ„± 39 제 1 절 λ™κ±°μ˜ μ‹œμž‘: β€˜κ·Έλƒ₯ μžμ—°μŠ€λŸ½κ²Œβ€™ 39 제 2 절 ν˜„μ‹€μ  λ¬Έμ œλ“€κ³Ό κ°ˆλ“± 43 제 3 절 μΉœλ°€μ„±μ˜ κ²½ν—˜κ³Ό 양상 51 제 3 μž₯ β€˜κ²°ν˜Όμ΄ μ•„λ‹Œβ€™ 동거 60 제 1 절 μ‚¬νšŒμ  낙인 61 제 2 절 동거 μΉœλ°€μ„±μ˜ νŠΉμ§•κ³Ό λ™κ±°μ˜ 지속 65 제 3 절 β€˜ν—€μ–΄μ§β€™μ˜ 어렀움 71 제 4 μž₯ 동거 β€˜κ°€μ‘±β€™μ˜ κ°€λŠ₯μ„± 75 제 1 절 가쑱이라 말(μ•ˆ)ν•˜κΈ° 75 제 2 절 λ™κ±°μ˜ 이점과 무게 79 제 3 절 λŒ€μ•ˆμ  μƒμ• κ³Όμ •μ˜ λͺ¨μƒ‰ 82 제 5 μž₯ κ²°λ‘  88 제 1 절 μš”μ•½ 88 제 2 절 λ…Όμ˜ 90 μ°Έκ³ λ¬Έν—Œ 94석

    Construction and application of standard data structure for simulation of shipbuilding scheduling

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    Competitiveness of shipbuilding and ocean product engineering of our country will be raised by Ship and Ocean plant product Engineering based on simulation that is such as a reliable production capacity, improvement of productivity and reducing costs. But the simulation system for shipbuilding and ocean plant is getting emphasized to be developed due to a shortage of simulation tool for the shipbuilding and ocean plant. Existing processes of production planning for shipbuilding should be analyzed to develop a shipbuilding and ocean interaction verification simulation system. Based on analyzed process, data of shipyard midterm planing and activity process is arranged and standardized After the function for shipbuilding and ocean interaction verification simulation system is grasped. Simulation input data type is based on extensible mark-up language for user to use input data for simulation system with standardized data structure. Through development of interface that changes to XML type when the simulation system is used in shipyard, the simulation system can be functioned even if user inputs each different data.List of tables List of figures Abstract 1. μ„œλ‘  1.1. 연ꡬ λ°°κ²½ 및 ν•„μš”μ„± 1.2. 연ꡬ λ‚΄μš© 2. μ‘°μ„ ν•΄μ–‘ 생산곡정 νŠΉμ„± 2.1. μ‘°μ„ ν•΄μ–‘ μƒμ‚°νŠΉμ„± 뢄석 2.2. κ΅­λ‚΄μ™Έ κΈ°μˆ λ™ν–₯ 3. μ‘°μ„ ν•΄μ–‘ 생산곡정 μΌμ •κ³„νš 자료ꡬ쑰 3.1. XML 3.2. XML μŠ€ν‚€λ§ˆ 3.3. WBS CODE 3.4. XML μŠ€ν‚€λ§ˆ λΆ„λ₯˜ 3.5. μΌμ •κ³„νš μŠ€ν‚€λ§ˆ 3.5.1. 쀑일정 μŠ€ν‚€λ§ˆ 3.5.2. WorkType μŠ€ν‚€λ§ˆ 3.5.3. WorkPackage μŠ€ν‚€λ§ˆ 3.5.4. WorkOrder μŠ€ν‚€λ§ˆ 3.5.5. Activity μŠ€ν‚€λ§ˆ 3.6. λΈ”λ‘μ •μ˜ 3.7. μ„€λΉ„μ •μ˜ 4. XML λ³€ν™˜ μΈν„°νŽ˜μ΄μŠ€ 4.1. μΈν„°νŽ˜μ΄μŠ€ 4.2. κ΅¬ν˜„ 5. κ²°λ‘  5.1. 연ꡬ결과 5.2. ν–₯ν›„κ³Όμ œ μ°Έκ³ λ¬Έ

    Blood Procalcitonin Level as A Diagnostic Marker of Pediatric Bacterial Meningitis: A Systematic Review and Meta-Analysis

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    Early diagnosis and treatment of bacterial meningitis in children are essential, due to the high mortality and morbidity rates. However, lumbar puncture is often difficult, and cerebrospinal fluid (CSF) culture takes time. This meta-analysis aims to determine the diagnostic accuracy of blood procalcitonin for detecting bacterial meningitis in children. We conducted a systematic search on electronic databases to identify relevant studies. Pooled sensitivity, specificity, and diagnostic odds ratio (DOR) were calculated, and a hierarchical summary receiver operating characteristic curve and area under the curve (AUC) were determined. Eighteen studies with 1462 children were included in the analysis. The pooled sensitivity, specificity, and the DOR of blood procalcitonin for detecting bacterial meningitis were 0.87 (95% confidence interval (CI): 0.78–0.93); 0.85 (95% CI: 0.75–0.91), and 35.85 (95% CI: 10.68–120.28), respectively. The AUC for blood procalcitonin was 0.921. Blood procalcitonin also showed higher diagnostic accuracy for detecting bacterial meningitis than other conventional biomarkers, including serum C-reactive protein and leukocyte count, CSF leukocyte and neutrophil count, and CSF protein and glucose levels. Blood procalcitonin can be a good supplemental biomarker with high diagnostic accuracy in detecting bacterial meningitis in children.ope

    Differences in Language Ability and Emotional-Behavioral Problems according to Symptom Severity in Children with Autism Spectrum Disorder

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    Purpose: The aim of this study was to investigate differences in language ability and emotional-behavioral problems according to the severity of social communication impairments (SCI) and restricted and repetitive behaviors (RRB) in children with autism spectrum disorders (ASD). Materials and methods: We grouped 113 children with ASD aged 3-12 years according to the severity of SCI and RRB, and investigated language differences and emotional-behavioral problems among the severity groups. If differences in language abilities between the groups were observed, they were further subdivided to examine possible predictors of both receptive and expressive language abilities. Results: In cluster analyses using subdomains of the Autism Diagnostic Interview-revised, severe SCI individuals showed lower language ability than their milder counterparts, while RRB showed no differences. Receptive and expressive language in the severe SCI group was negatively predicted by social communication and social motivation, respectively. The severe RRB group showed significantly higher levels of anxiety/distress, somatic complaints, thought problems, attention problems, and aggressive behavior, while the severe SCI group was reported to be more withdrawn. Conclusion: The results of this study suggest that the severity of SCI greatly affects language ability. In children with severe SCI, social communication and social motivation negatively predicted receptive language and expressive language, respectively. Children with severe RRB may have more emotional-behavioral problems that require active intervention.ope

    The Impact of Employment Support and Career Guidance of Specialized vocational High Schools on Job Satisfaction : With Focus on the Mediating Effect of Job and Major Congruence

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    λ³Έ μ—°κ΅¬λŠ” νŠΉμ„±ν™”κ³ μ—μ„œ μ΄λ£¨μ–΄μ§€λŠ” μ§„λ‘œμ§€λ„ 및 취업지원 ν”„λ‘œκ·Έλž¨μ΄ μ§μ—…λ§Œμ‘±λ„μ— μ–΄λ–€ 영ν–₯을 λ―ΈμΉ˜λŠ”κ°€λ₯Ό μ‚΄νŽ΄λ³΄κΈ° μœ„ν•˜μ—¬ νŠΉμ„±ν™”κ³ μ˜ μ§„λ‘œμ§€λ„ 및 취업지원과 μ§μ—…λ§Œμ‘±λ„ 사이에 μ§λ¬΄μΌμΉ˜λ„κ°€ λΆ€λΆ„μ μœΌλ‘œ λ§€κ°œν•  κ²ƒμ΄λΌλŠ” 가섀을 μ„€μ •ν•˜κ³ ,이λ₯Ό ꡬ쑰방정식 λͺ¨ν˜•μ„ μ„€μ •ν•˜μ—¬ λΆ„μ„ν•˜μ˜€λ‹€. 이λ₯Ό μœ„ν•˜μ—¬ ν•œκ΅­κ³ μš©μ •λ³΄μ›μ˜ '2011λ…„ 고쑸자 μ·¨μ—…μ§„λ‘œμ‘°μ‚¬(HSCOMS)' 자료λ₯Ό ν™œμš©ν•˜μ˜€λ‹€. λ³Έ μ—°κ΅¬μ˜ 뢄석 κ²°κ³Ό, νŠΉμ„±ν™”κ³ μ˜ μ§„λ‘œμ§€λ„ 및 취업지원에 λŒ€ν•œ λ§Œμ‘±λ„κ°€ λ†’μ„μˆ˜λ‘ μ‘Έμ—…μƒλ“€μ˜ μ§μ—…λ§Œμ‘±λ„κ°€ λ†’κ²Œ λ‚˜νƒ€λ‚¬μœΌλ©°, μ§λ¬΄μΌμΉ˜λ„κ°€ λ†’μ„μˆ˜λ‘ μ§μ—…λ§Œμ‘±λ„κ°€ λ†’μ•„μ‘Œλ‹€. λ˜ν•œ νŠΉμ„±ν™”κ³ μ˜ μ§„λ‘œμ§€λ„ 및 취업지원 ν”„λ‘œκ·Έλž¨μ€ 학생듀이 μ „κ³΅μ—λΆ€ν•©ν•˜λŠ” 일자리둜 μ§„μž…ν•˜λŠ”λ° μœ μ˜λ―Έν•œ 영ν–₯을 μ£Όκ³ , μ§λ¬΄μΌμΉ˜λ„λ₯Ό 맀개둜 μ§μ—…λ§Œμ‘±λ„μ— 긍정적 영ν–₯을 λ―ΈμΉ˜λŠ” κ²ƒμœΌλ‘œ λ‚˜νƒ€λ‚¬λ‹€.This study seeks to examine the impact of specialized vocational high schools' employment support and career guidance on graduates' job satisfaction. Assuming a mediating effect of congruence between jobs and majors among career guidance, employment support, and job satisfaction, a structural equation model was proposed to analyze the study's model using the "2011 Korea Employment Information Service's High School Graduates Occupational Mobility Survey". The study results showed a positive influence from career guidance and employment support on graduates' job satisfaction. Also, higher congruence between jobs and majors results in higher job satisfaction. In addition, the study revealed that the career guidance and employment support programs in specialized vocational high schools have a significant effect on the students' efforts to find a job that is relevant to their majors. Job and major congruence also had positive influence on job satisfaction by acting as a mediator

    MicroRNA-139-5p Regulates Fibrotic Potentials via Modulation of Collagen Type 1 and Phosphorylated p38 MAPK in Uterine Leiomyoma

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    Purpose: This study aimed to elucidate whether microRNA-139-5p is involved in the pathogenesis of uterine leiomyoma. Materials and methods: Human leiomyoma and matched human smooth muscle samples were obtained from 10 women who underwent hysterectomy for uterine leiomyoma. MicroRNA (miRNA) expression was analyzed by quantitative real-time polymerase chain reaction. To assess the effects of miR-139-5p on cultured leiomyoma cells, cell migration, collagen gel contraction, wound healing, and the expression levels of hallmark proteins were evaluated in cells transfected with a miR-139-5p mimic. Results: The expression of miR-139-5p was significantly lower in leiomyoma tissues than in matched smooth muscle tissues. Restored miR-139-5p expression in miR-139-5p mimic-transfected human leiomyoma cells resulted in decreased contractility of the ECM and cell migration. In addition, upregulation of miR-139-5p decreased the protein expression of collagen type 1 and phosphorylated p38 MAPK. Conclusion: Expression of miR-139-5p is downregulated in leiomyoma cells and modulation of miR-139-5p may be involved inthe pathogenesis of leiomyomas through the regulation of collagen type 1 and phosphorylated p38 MAPK. Therefore, miR-139-5p is a potential therapeutic target for leiomyoma.ope

    Hormone autocrination by vascularized hydrogel delivery of ovary spheroids to rescue ovarian dysfunctions

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    The regeneration potential of implantable organ model hydrogels is applied to treat a loss of ovarian endocrine function in women experiencing menopause and/or cancer therapy. A rat ovariectomy model is used to harvest autologous ovary cells while subsequently producing a layer-by-layer form of follicle spheroids. Implantation of a microchannel network hydrogel with cell spheroids [vascularized hydrogel with ovarian spheroids (VHOS)] into an ischemic hindlimb of ovariectomized rats significantly aids the recovery of endocrine function with hormone release, leading to full endometrium regeneration. The VHOS implantation effectively suppresses the side effects observed with synthetic hormone treatment (i.e., tissue overgrowth, hyperplasia, cancer progression, deep vein thrombosis) to the normal levels, while effectively preventing the representative aftereffects of menopause (i.e., gaining fatty weight, inducing osteoporosis). These results highlight the unprecedented therapeutic potential of an implantable VHOS against menopause and suggest that it may be used as an alternative approach to standard hormone therapy.ope

    Predictive Factors of Conception and the Cumulative Pregnancy Rate in Subfertile Couples Undergoing Timed Intercourse With Ultrasound

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    The aim of this study was to determine predictive factors for pregnancy and assess the cumulative pregnancy rate (CPR) and live birth rate (CLBR) in subfertile couples undergoing timed intercourse (TI) using ultrasound. This retrospective cohort study included 285 women (854 cycles) who started TI with ultrasound between January 2017 and October 2019. The overall clinical pregnancy rate was 28.1% (80/285) per couple and 9.4% (80/854) per cycle. Pregnant women had a higher body mass index (BMI), higher percentage of irregular menstrual cycles, a shorter duration of subfertility, lower serum follicle-stimulating hormone levels, and higher anti-MΓΌllerian hormone levels than non-pregnant women. A longer duration of subfertility (β‰₯24 months vs. 25 kg/m2; odds ratio: 3.202; 95% confidence interval: 1.020-10.046) in couples with ovulatory factor and a longer duration of infertility β‰₯24 months (vs. <24 months; odds ratio: 0.185; 95% confidence interval: 0.042-0.819) in couples with non-ovulatory factors were significant independent predictive factors for pregnancy. No significant differences were found in the cycle characteristics between pregnant and non-pregnant women. The CPR substantially increased during the first three cycles and significantly increased until the sixth cycle. No significant increase was observed in the CPR after the sixth cycle. The CLBRs substantially increased during the first three cycles and significantly increased until the fourth cycle. No significant increase was observed in the CLBRs after the fifth cycle. When comparing CPRs and CLBRs according to subfertile causes, CRPs was significantly different and CLBRs was different with borderline significance. Our findings may indicate that women with a longer duration of subfertility or subfertility due to endometriosis have poor outcomes during TI with ultrasound. Women who failed to achieve conception by the fourth or fifth cycle of TI with ultrasound may be encouraged to consider advancing to the next treatment strategy.ope

    Relationship between the expression of cyclin B1, D1 and the various prognostic factors in ovarian carcinoma

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    μ˜ν•™κ³Ό/석사[ν•œκΈ€] λ‚œμ†Œμ•”μ—μ„œ μ‹€μ‹œκ°„ μ •λŸ‰ 역전사 μ€‘ν•©νš¨μ†Œ 연쇄 λ°˜μ‘ (quantitative real-time reverse transcriptase-polymerase chain reaction, quantitative real-time RT-PCR)을 μ΄μš©ν•œ cyclin B1κ³Ό D1의 mRNA λ°œν˜„κ³Ό Western blot analysisλ₯Ό μ΄μš©ν•œ cyclin B1κ³Ό D1의 λ‹¨λ°±μ§ˆ λ°œν˜„μ„ μ—°κ΅¬ν•˜κ³  λ˜ν•œ 이것과 μ—¬λŸ¬ μž„μƒ μ˜ˆν›„ μΈμžλ“€κ³Όμ˜ 상관관계λ₯Ό μ•Œμ•„λ³΄κ³ μž ν•˜μ˜€λ‹€.μ—°μ„ΈλŒ€ν•™κ΅ μ„ΈλΈŒλž€μŠ€λ³‘μ› μ‚°λΆ€μΈκ³Όμ—μ„œ 2002λ…„ 3μ›”λΆ€ν„° 2005λ…„ 2μ›”κΉŒμ§€ 수술적 치료λ₯Ό 받은 ν™˜μžλ₯Ό λŒ€μƒμœΌλ‘œ 연ꡬλ₯Ό μ‹œν–‰ν•˜μ—¬ μ‹ μ„ ν•œ λ‚œμ†Œμ•” 쑰직 36예, 정상 λ‚œμ†Œ 쑰직 5예λ₯Ό μ–»μ—ˆλ‹€.μ‹€μ‹œκ°„ μ •λŸ‰ 역전사 μ€‘ν•©νš¨μ†Œ 연쇄 λ°˜μ‘μ— μ˜ν•œ λ‚œμ†Œμ•” μ‘°μ§μ—μ„œμ˜ cyclin B1κ³Ό D1 mRNA 2-β–³β–³CT κ°’μ˜ 평균은 각각 5.83 Β± 12.03κ³Ό 17.60 Β± 22.20 μ˜€κ³ , λŒ€μ‘°κ΅°μ€ 각각 0.55 Β± 0.35κ³Ό 0.50 Β± 0.26둜 두 ꡰ간에 차이λ₯Ό λ³΄μ΄λ‚˜ ν†΅κ³„μ μœΌλ‘œ μœ μ˜ν•˜μ§€ μ•Šμ•˜λ‹€. (p=0.67, p=0.07) Western blot analysis에 μ˜ν•œ cyclin B1κ³Ό D1 densitometer 값을 λŒ€μ‘°κ΅°μ—μ„œ 1둜 λ³΄μ•˜μ„ λ•Œ, λ‚œμ†Œμ•” 쑰직은 각각 1.30 Β± 0.73κ³Ό 1.81 Β± 1.28둜 두 ꡰ간에 차이λ₯Ό λ³΄μ΄λ‚˜ ν†΅κ³„μ μœΌλ‘œ μœ μ˜ν•˜μ§€ μ•Šμ•˜λ‹€. (p=0.76, p=0.06) Cyclin B1κ³Ό D1의 mRNA 및 λ‹¨λ°±μ§ˆ λ°œν˜„μ€ μž„μƒ 병리학적 μ˜ˆν›„ 인자인 λ‚œμ†Œμ•”μ˜ 외과적 병기, 혈청 λ‚΄ CA-125, μœ μ„Έν¬ 뢄석법을 ν†΅ν•œ DNA μ •λŸ‰κ²€μ‚¬ λ“±κ³Ό ν†΅κ³„μ μœΌλ‘œ 상관관계λ₯Ό 보이지 μ•Šμ•˜λ‹€.결둠적으둜, λ³Έ μ—°κ΅¬μ—μ„œλŠ” cyclin B1κ³Ό D1의 mRNA 및 λ‹¨λ°±μ§ˆ λ°œν˜„μ΄ λ‚œμ†Œμ•” μ‘°μ§μ—μ„œ λŒ€μ‘°κ΅°λ³΄λ‹€ μ¦κ°€λ˜μ–΄ cyclin B1κ³Ό D1이 λ‚œμ†Œμ˜ μ’…μ–‘ν˜•μ„± (tumorigenesis)κ³Ό 악성도에 κ΄€μ—¬ν•  κ²ƒμœΌλ‘œ μΆ”μ •λ˜μ—ˆλ‹€. κ·ΈλŸ¬λ‚˜ cyclin B1κ³Ό D1의 mRNA 및 λ‹¨λ°±μ§ˆ λ°œν˜„μ€ μž„μƒ 병리학적 μ˜ˆν›„ μΈμžλ“€κ³Ό ν†΅κ³„μ μœΌλ‘œ 상관관계λ₯Ό 보이지 μ•Šμ•˜λ‹€. Cyclin이 λ‚œμ†Œμ•”μ—μ„œ μ˜ˆν›„ μΈμžλ‘œμ„œ κ°€μΉ˜κ°€ μžˆλŠ”μ§€ ν‰κ°€ν•˜λ €λ©΄ λ°œν˜„ 양상과 μΉ˜λ£Œμ œμ— λŒ€ν•œ λ°˜μ‘, μƒμ‘΄μœ¨ 등을 μ—°κ΄€μ‹œν‚¨ 연ꡬ가 λ’·λ°›μΉ¨λ˜μ–΄μ•Ό ν•  κ²ƒμœΌλ‘œ μ‚¬λ£Œλœλ‹€. [영문]Objective: The objective of this study was to evaluate the relationship between the expression of cyclin B1, D1 and the various prognostic factors in ovarian carcinoma.Material and Methods: In this study, fresh ovarian tissue samples were obtained from 41 patients treated surgically at Yonsei University College of Medicine from May of 2002 to February of 2005. These included 36 ovarian carcinoma and 5 normal ovarian tissues that served as the control. Quantitative real-time RT-PCR and Western blot analysis were used in detecting the expression of mRNA and protein of cyclin B1, D1, respectively.Results: The mean 2-β–³β–³CT value of cyclin B1 and D1 mRNA in ovarian carcinoma tissue obtained through quantitative real-time RT-PCR was 5.83 Β± 12.03, 17.60 Β± 22.20, respectively, and the mean value in the control was 0.55 Β± 0.35, 0.50 Β± 0.26, respectively. The results showed difference in the expression, but were not statistically significant. (p=0.67, 0.07) If the mean densitometer value of cyclin B1 and D1 protein in the control obtained by Western blot analysis was 1, the mean value in ovarian carcinoma tissue was higher (1.30 Β± 0.73, 1.81 Β± 1.28, respectively). (p=0.76, 0.06) The expression of cyclin B1, D1 and various prognostic factors was not statistically related.Conclusion: Our results showed that the expression of cyclin B1 and D1 in ovarian carcinoma tissue was higher than in the normal control. This suggested that cyclin B1, D1 and the tumorigenesis and the degree of malignancy was closely related. But the expression of cyclin B1, D1 and various prognostic factors was not statistically related. Further studies based on the correlation between cyclin and response to treatment or survival rate are needed to support cyclin as a prognostic factor of ovarian carcinoma.ope
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