Clinical study of surgical diseases of large intestine in Korea

의학과/석사[한글] [영문]This clinical study of surgical diseases of large intestine in Korea was done with those patients who have been diagnosed histologically and treated surgically from 1952 to 1967 at Yonsei Medical Center and with articles which had been reported by several authors in Korea. Intestinal tuberculosis is still frequently seen in Korea where the number of active pulmonary tuberculosis cases is as high as 5.1 percent of all populations, while the disease is extremly rare in western countries since the use of antituberculous agents. Because there are no typical symptoms and signs in tuberculous colitis, and also because of occasional difficulty in differentiating tuberculosis of the colon from colonic carcinoma, it is often a candidate of operative disease of large bowel in Korea. Although diverticulosis and diverticulitis of large bowel is one of the most common disease in geriatrie patients in America and Europe, it is one of the extremly rare diseases in Korea. We presume that this phenomena is due to diet habit; possibly the low residue diet in the west may delay the propulsion and accentuate the dessication of the intracolonic contents, causing increased pressure within lumen thereby develops the diverticulosis around the sigmoid colon. Ulcerative colitis and polyposis of the colon are decidely rare in Korea in comparison with western countries. The carcinoma of the large bowel is less frequent seen in Korea than in the west where it is most common cancer. We are of the opinion that the low rate of incidence of the carcinoma of large bowel is due to the following factors; first, the low rate of incidence of polyp and ulcerative colitis which thought premalignant lesion in colon, second, the living conditions including diet. Crohn's disease was at first described as "terminal ileitis" but later similar pathologic changes in stomach and large bowel have been reported. In several cases that we have studied, Crohn's disease was located more often in the large bowel than in terminal ileum unlike the cases reported in western countries.restrictio

열대 해면동물로부터 분리된 생리활성 테르페노이드와 알칼로이드 물질의 구조결정

학위논문 (박사)-- 서울대학교 대학원 : 약학과, 2017. 2. 신종헌.화학적 분석방법과 생리활성 측정을 통하여 선별된 4 종의 열대 해면 (Coscinoderma sp., Dysidea sp., Callyspongia sp. 그리고 Acanthostrongylophora sp.) 에서 추출한 유기물질들을 다양한 크로마토 그래피 법으로 분리 및 정제 하여 25 개의 순수한 물질들을 얻었다. 각각의 분광학 자료에 의하여 19 종의 신물질들을 구조 결정하였으며 6 종의 기지물질들을 동정하였다. 이들의 입체구조 결정을 위하여 화학적 방법과 분광학 자료분석 등 다양한 방법이 시도되었다. 분리된 물질들은 8 종의 suvanine 계 sesterterpene sulfates 및 lactams, 2 종의 deacyl irciniasulfonic acid 계 modified fatty acids, 7 종의 meroterpenoid 계 sesquiterpene qunones, 2 종의 nitrogenous macrocycles, 6 종의 manzamine 계 carboline-macrocycles 인 것으로 밝혀졌다. 분리된 물질들은 세포독성검사 (K562 human erythroleukemia cell, A549 lung carcinoma cell), 항미생물검사 (그람양성박테리아, 그람음성 박테리아, 병원성진균), 효소저해 검사 (Na+/K+-ATPase, isocitrate lyase, sortase A) 등이 실시되었고, 몇몇의 물질들은 주목할만한 세포독성, 항미생물활성, Na+/K+-ATPase 저해활성이 있는 것으로 나타났다.I. Introduction 1 II. Studies on the Metabolites from Marine Sponges 7 1. Suvanine Sestertepenes and Deacyl Irciniasulfonic acids from a Tropical Coscinoderma sp. Sponge 7 1-1. Introduction. 8 1-2. Results and discussion 10 1-3. Experimental section 22 2. Meroterpenoids from a Tropical Dysidea sp. Sponge 46 2-1. Introduction. 46 2-2. Results and discussion 48 2-3. Experimental section 62 3. Callyazepin and (3R)-Methylazacyclodecane, Nitrogenous Macrocycles from a Callyspongia sp. Sponge 74 3-1. Introduction. 74 3-2. Results and discussion 76 3-3. Experimental section. 88 4. New Manzamine Alkaloids from the Indonesian Sponge Acanthostrongylophora sp. 97 4-1. Introduction. 97 4-2. Results and discussion 99 4-3. Experimental section 106 III. Conclusion 120 Summary 121 References 127 Appendix A : NMR Spectroscopic Data 136 Appendix B : Supporting Information 158 Abstract in Korean 171 Publication List 173Docto

Halenaquinone derivatives from tropical marine sponge Xestospongia sp.

Tropical marine sponges are fertile sources of secondary metabolites with novel molecular architectures. A variety of pentacyclic quinone and hydroquinone compounds has been isolated from marine sponge Xetospongia sp. These secondary metabolites have exhibited useful biological activities such ascardiotonicity, cytotoxicity, and enzyme inhibition. During our research for bioactive substances from tropical marine organisms, we isolated halenaquinolsulfate, xestoquinolsulfate, halenaquinone, tetrahydrohalenaquinone A, B, adociaquinone B, and xestosaprol from Xestospongia sp. collected from Chuuk, Federated State of Micronesia. The structures of these halenaquinone derivatives were elucidated on the basis of the spectral methods.2

규칙 도출 기법을 이용한 시장세분화에 관한 연구

학위논문(석사) - 한국과학기술원 : 산업공학과, 1989.2, [ [iii], 57 p. ]This study suggests an algorithm for splitting the values of dependent variable (class) while maximizing the information gain about numerical and nominal attributes. Rule induction has been proposed as a way to speed up an acquisition of knowledge for development of expert systems, especially it is a method of automatically developing rules from sets of examples. For market segmentation, the original ID3 algorithm must be modified since it does not exist intermediate stopping rule. Thus, this study suggests an adequate stopping rule. The modified algorithm contains the pruning measure based on Shannon``s entropy and the measure of total information gain. This algorithm is applied to market segmentation problem in medium-large level computer market, in order to develop an adequate market strategy. The derived rule-tree, that transformed in the form of a production rule, classifies the competitive products and in the several market segment well.한국과학기술원 : 산업공학과