93 research outputs found
Validation of risk prediction models for the development of HBV-related HCC: a retrospective multi-center 10-year follow-up cohort study
Recently, modified REACH-B (mREACH-B) risk prediction model for hepatocellular carcinoma (HCC) development was proposed. We validated the accuracy of the mREACH-B model and compared its accuracy with those of other prediction models. Between 2006 and 2012, 1,241 patients with chronic hepatitis B (CHB) were recruited. All patients underwent transient elastography at enrollment. The median age of the study population (840 males, 401 females) was 49 years. The median PAGE-B, LSM-HCC, and mREACH-B values were 10, 10, and 8, respectively. Among patients without cirrhosis (n = 940, 75.7%), the median REACH-B value was 9. During the follow-up period (median 77.4 months), 66 (5.3%) and 83 (6.7%) patients developed HCC and liver-related events (LRE), respectively. Higher liver stiffness (LS) independently predicted HCC (hazard ratio [HR] = 1.047) and LRE development (HR = 1.047) (all P < 0.05). The mREACH-B significantly predicted HCC (AUC = 0.824 at 3-year and 0.750 at 5-year) and LRE development (AUC = 0.782 at 3-year and 0.739 at 5-year) (all P < 0.001) and it performed similarly or significantly better than the PAGE-B and LSM-HCC (AUC = 0.715-0.809 at 3-year and 0.719-0.742 at 5-year for HCC; AUC = 0.704-0.777 at 3-year and 0.721-0.735 at 5-year for LRE). Among patients without cirrhosis, mREACH-B predicted HCC (AUC = 0.803 vs. 0.654-0.816 at 3-year and 0.684 vs. 0.639-0.738 at 5-year) and LRE development (AUC = 0.734 vs. 0.619-0.789 at 3-year and 0.674 vs. 0.626-0.729 at 5-year) similarly to PAGE-B, REACH-B, and LSM-HCC. mREACH-B appropriately predicted HCC and LRE development in patients with CHB and showed similar or superior accuracy to those of PAGE-B, REACH-B, and LSM-HCC.ope
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Όλ¬Έ(μμ¬)--μμΈλνκ΅ νκ²½λνμ :νκ²½κ³ννκ³Ό νκ²½κ΄λ¦¬μ 곡,1996.Maste
A Study on the Potential Impact of Autonomous Vehicles on Suburban Migration and Commute Time Limit : Focused on Metropolitan Areas
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Όλ¬Έ (μμ¬)-- μμΈλνκ΅ λνμ : νκ²½λνμ νκ²½κ³ννκ³Ό, 2018. 2. μ΄μμ±.μμ¨μ£Όνμλμ°¨μ λμ
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νλ―λ‘ λ³νμ κ°λλ₯Ό μμΈ‘ν΄λ³Έλ€. λ³Έ μ°κ΅¬μ κ²°κ³Όλ₯Ό μμ¨μ£Όνμλμ°¨μ λμ
μ λ°λΌ λνλ λ³νλ€μ λλΉνκΈ° μν μ°Έκ³ μλ£λ‘ μ μνλ―λ‘ ν₯ν μ€λ§νΈμν° κ΅¬μΆμ μμ΄ κ²½μ μ , μ¬νμ , νκ²½μ μΌλ‘ λμ± μ ν©ν λ°μ λ°©ν₯μ λλͺ¨νλλ° κΈ°μ¬νκ³ μ νλ€.The introduction of autonomous vehicles (AVs) can be considered as the introduction of a disruptive technology which would completely change the paradigm of transportation. In particular, level 4 self-driving (fully autonomous driving) will allow passengers to freely relax without driving, do work or enjoy leisure during transportation times. This means that AVs will lead to the decrease in transportation costs and create benefits during transportation. Commuters who prefer cheaper and more spacious housing and better natural environment are expected to show a tendency preferring suburban areas in relation to their residential choice with this decrease in transportation cost. Suburbanization is linked to many urban problems such as job-housing mismatch and inner city decline. Therefore, the factors related to suburbanization need to be predicted in order to derive sustainable urban development policies
The hypothesis of this study is that the introduction of AVs will lead to the decrease in transportation costs and this will trigger a tendency of suburban migration among citizens of Seoul. In order to verify this, this study surveys 383 respondents who live in Seoul, Korea. First, the characteristics of respondents who are willing to utilize AVs are investigated. Second, the characteristics of respondents who are willing to move to suburban areas with the introduction of AVs are also investigated. Third, the potential change in transportation time and preferred commute time limit with AVs is predicted. Based on the results of this study, it is suggested that measures for urban planning should be designed to prepare for the changes that will result from the future introduction of AVs to the city.β
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λΆλ‘ 63Maste
λλ¦Ό : 건μ€λΆλ¬Έ ꡬ쑰쑰μ
Thesis(master`s)--μμΈλνκ΅ κ²½μμ λ¬Έλνμ :κ²½μνκ³Ό Global MBAμ 곡,2007.8Maste
Artemisiaμ Green Tea μΆμΆ 볡ν©λ¬Όμ Heat-shock Protein 27 λ°ν μ¦κ°λ₯Ό ν΅ν μμ½μ¬μ± μμΌ μ΅μ ν¨κ³Ό
Background/Aims: Several lines of evidence from epidemiologic and laboratory studies have shown that the consumption of Artemisia or green tea extracts (MPGT) is inversely associated with the risk of alcohol-induced damage and other chronic diseases. Supported by previous studies showing that the combined extract of Artemisia and green tea, MPGT, exerted significantly either antioxidative or anti-inflammatory actions against Helicobacter pylori-associated gastric diseases, it was hypothesized that MPGT can offer protection against alcoholic gastritis.Methods: Ethanol was administered to induce gastric damage in Wistar rats, which had been pretreated with various doses of MPGT, to measure the rescuing action of a MPGT pretreatment against ethanol-induced gastric damage. In addition, the molecular mechanisms for the preventive effects were examined.Results: The MPGT pretreatment (100, 300, and 500 mg/kg) alleviated the ethanol-induced gastric damage, which was evidenced by the significant decrease in calcium-dependent phospholipase A2, MAPKs, and NF-B levels compared to ethanol alone. Furthermore, the MPGT pretreatment preserved 15-prostaglandin dehydrogenase, whereas cyclooxygenase-2 was decreased significantly. All of these biochemical changes led to the significant alleviation of alcohol-associated gastric mucosal damage. Ethanol significantly increased the TUNEL positivity in the stomach, but MPGT decreased the apoptotic index significantly, which was associated with significantly lower pathological scores of ethanol-induced mucosal ulcerations. The significant protective changes observed alcoholic gastritis with MPGT were related to the increased expression of cytoprotective genes, such as heat-shock protein (HSP)27, HSP60, and PDGF.Conclusions: The efficient anti-inflammatory, anti-apoptotic, and regenerative actions of MPGT make it a potential nutrient phytoceutical to rescue the stomach from alcoholic gastritis.Financial support: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministryof Education (2014R1A1A2058732 to JM Park), by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET)through High Value-added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (116015-03-1-CG000), andalso by Japanese Society for Promotion of Science
맀λ¬λ¦° λΆνμ νλ€λ¦Ό μ΅μ λ₯Ό μν λΉμ Ό μμ€ν μ μ¬μ©νμ§ μλ μ μ΄ μμ€ν
Thesis (doctoral)--μμΈλνκ΅ λνμ :μ κΈ°Β·μ»΄ν¨ν°κ³΅νλΆ,2002.Docto
A study on the management system and working range of optician in Korea
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무λ²μλ₯Ό λ²μ΄λ κ΅κ³Όλͺ©μ΄ λμ΄λ κ²μ΄ νμ€μ΄λ€. μ΄λ¬ν νμ€μ λ¬Έμ μ μ΄ λΆκ°λλ κ³³μ γμλ£κΈ°μ¬ λ±μ κ΄ν λ²λ₯ μνλ Ή μ 2μ‘° 1ν 8νΈγκ° μκ²½μ¬μ μ
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λ¬΄μΈ μλ ₯보μ μ μμ΄μλ μλκ΅΄μ κ²μ¬κΈ°κΈ°λ₯Ό μ¬μ©ν νκ°μ κ΅΄μ κ²μ¬μ μκ°μ κ΅΄μ κ²μ¬λ‘ κ°λ₯νλ€. κ·Έλ¬λ―λ‘ βμλκ΅΄μ κ²μ¬κΈ°κΈ°λ₯Ό μ¬μ©νμ§ μλνλ νκ°μ κ΅΄μ κ²μ¬βλΆλΆμ κ΅μ‘κ³Όμ κ³Ό κ΅κ°μνμ μΆμ λ²μμμ λ°°μ νλ κ²μ΄ νλΉνλ€. μ΄λ₯Ό ν΅ν΄ μκ²½μ¬μ κ΄λ ¨λ γμλ£κΈ°μ¬ λ±μ κ΄ν λ²λ₯ γκ³Ό κ΅μ‘κ³Όμ , κ΅κ°μνμ λλ₯Ό λ°λ‘ λλ μκ³λ°λμ²λΌ λλ κ²μ΄ μλλΌ κ°μ΄ λλ μλ λ°ν΄κ° λλλ‘ νμ¬μΌ νλ€.
[μλ¬Έ]restrictio
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Όλ¬Έ(μμ¬) --μμΈλνκ΅ λνμ :μνκ³Ό λ΄κ³Όν μ 곡,2007.Maste
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