7 research outputs found
Development and Evaluation of a Creative Problem Solving Program for Cyberbullying Prevention
λ³Έ μ°κ΅¬λ μ°½μμ λ¬Έμ ν΄κ²°λ°©λ²μ νμ©ν μ¬μ΄λ²λΆλ§ μλ°©κ΅μ‘ νλ‘κ·Έλ¨μ κ°λ°νκ³ κ°λ°λ νλ‘κ·Έλ¨μ ν¨κ³Όλ₯Ό νμΈνκΈ° μνμ¬ μ΄λ±νκ΅ νμ₯μ μ μ©νμ¬ μ΄κΈ° μ²μλ
μ μ¬μ΄λ²λΆλ§ κ²½ν, μ¬μ΄λ²λΆλ§ νλ, μ°½μμ λ¬Έμ ν΄κ²°μ λ―ΈμΉλ ν¨κ³Όμ λν΄μ μ΄ν΄λ³΄κ³ μ νμλ€. λ³Έ μ°κ΅¬μμλ Treffinger, Isaksenμ Dorval(2000)μ μ°½μμ λ¬Έμ ν΄κ²°κ³Όμ μ κ·Όκ±°νμ¬ μ°½μμ λ¬Έμ ν΄κ²°λ°©λ²μ νμ©ν μ¬μ΄λ²λΆλ§ μλ°©κ΅μ‘ νλ‘κ·Έλ¨μ κ°λ°νμλ€. μ°κ΅¬ μ°Έμ¬μλ κ²½κΈ°λμ μμ¬ν μ΄λ±νκ΅ 5νλ
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μ΄λ€(μ€νμ§λ¨: 25λͺ
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). λ³Έ μ°κ΅¬μμλ μ€νμ§λ¨μ μνλ μ²μλ
λ€μκ² 4μ£Όκ° 8μ°¨μλ‘ κ΅¬μ±λ νλ‘κ·Έλ¨μ μννμμΌλ©°, κ°μ μκΈ° λΉκ΅μ§λ¨μ μνλ μ²μλ
μκ²λ 1νμ± μ 보μ λ¬μ μλ°©κ΅μ‘μ μ€μνμλ€. νλ‘κ·Έλ¨ μ€ν μ Β·νμ μ°¨μ΄λ₯Ό λΉκ΅νκΈ° μνμ¬ λ³Έ μ°κ΅¬μμλ μ¬μ΄λ²λΆλ§ κ²½ν, μ¬μ΄λ²λΆλ§ νλ, λμΈκ΄κ³ λ¬Έμ ν΄κ²°κ³Ό μ°½μμ λ¬Έμ ν΄κ²° μ²λλ₯Ό νμ©νμλ€. μ°κ΅¬ κ²°κ³Ό, μ¬μ΄λ²λΆλ§λ°©κ΄ λ° λ°©μ΄ νλ, μ¬μ΄λ²λΆλ§ νλ, μ°½μμ λ¬Έμ ν΄κ²°, λμΈ λ¬Έμ ν΄κ²°μ΄ ν₯μλ κ²μ μ μ μμλ€.
μ€νμ§λ¨κ³Ό λΉκ΅μ§λ¨μ λΉκ΅νμμ λμλ μ¬μ΄λ²λΆλ§ λ°©κ΄ λ° λ°©μ΄ νλ, μ¬μ΄λ²λΆλ§ νλ, λμΈ λ¬Έμ ν΄κ²°μμ μ μν μ°¨μ΄λ₯Ό 보μ΄λ κ²μ νμΈν μ μμλ€. μ΄λ₯Ό ν΅νμ¬ μ°½μμ λ¬Έμ ν΄κ²°λ°©λ²μ νμ©ν μ¬μ΄λ²λΆλ§ μλ°©κ΅μ‘ νλ‘κ·Έλ¨μ΄ μ²μλ
μ μ¬μ΄λ²λΆλ§ μλ°©μ ν¨κ³Όμ μΌ λΏλ§ μλλΌ λ¬Έμ ν΄κ²°μμ¦μ§μν€λλ°λ λμμ΄ λ¨μ μ μ μμλ€.N
ν λ‘λ¨ΈλΌμ μ λ ν©νμ΄λμ μ’ μ μ΅μ ν¨κ³Όμ κ΄ν μ°κ΅¬
νμλ
Όλ¬Έ (λ°μ¬)-- μμΈλνκ΅ λνμ : νλκ³Όμ μ’
μμλ¬Όνμ 곡, 2015. 8. κΉλ²μ€.Heat shock proteins (HSPs) are molecular chaperones that have critical roles in maintaining protein homeostasisthey are critical for cell survival especially under stresses such as hypoxia. HSPs, particularly HSP90 and HSP70, are highly expressed in a wide range of tumors. The expression of several HSPs has been shown to be correlated with tumor cell proliferation, differentiation and apoptosis in several cancers. A reverse-transcriptase subunit of telomerase (hTERT) derived peptide, GV1001 (Kael-GemVex Co. Ltd., Seoul, Korea) is a 16mer amino acid peptide, which was selected based on computer algorithms that predicted strong HLA class II binding properties encoded by multiple alleles from the HLA-DR, -DP, and ?DQ loci, thereby eliciting the T helper cell response in up to 80% of vaccinated patients and multiple nested HLA class I binding motifs. Subject to peptide processing by endogenous APCs, vaccination with GV1001 may thus recruit both CD4+ T cells and CD8+ cytotoxic T cells. Although GV1001 has been developed as a vaccine against various cancers, we have shown that GV1001 interacts with HSPs and lowers the level of intracellular and surface HSPs from various cancer cells. In hypoxic conditions, GV1001 treatment of cancer cells resulted in decreases of HSP90, HSP70, and HIF-1Ξ±. Subsequently, proliferation of cancer cells and synthesis of VEGF were significantly reduced by treatment with GV1001 in hypoxic conditions. In an experiment with a nude mouse xenograft model, GV1001 exerted a similar tumor suppressive effect, further confirming its anti-tumor efficacy. Higher apoptotic cell death, reduced proliferation of cells, and fewer blood vessels were observed in GV1001-treated tumors compared to the control. In addition, a significant decrease in Tie2+ CD11b+ monocytes, which were recruited by VEGF from tumor cells and have a critical role in angiogenesis, was observed in the GV1001-treated tumors. Collectively, the results suggest that GV1001 possesses potential therapeutic efficacy in addition to its ability to induce anti-cancer immune responses by suppressing both HSP70 and HSP90.Abstract
Contents
List of Figures
Introduction
Purpose
Materials and Methods
Results
Discussion
Conclusion
References
Korean AbstractDocto
Content Analysis of Creative Problem Solving Program for Cyberbullying Prevention
λ³Έ μ°κ΅¬λ μ°½μμ λ¬Έμ ν΄κ²°λ°©λ²μ νμ©ν μ¬μ΄λ²λΆλ§ μλ°© κ΅μ‘ νλ‘κ·Έλ¨ μ°Έμ¬ κ²½νμ΄ μ²μλ
λ€μμ λ³νμ λ―ΈμΉλ μν₯μ νμΈνκ³ μ νμλ€. μ΄λ₯Ό μνμ¬ νλ‘κ·Έλ¨μ μ°Έκ°ν μ΄λ±νκ΅ 5νλ
μ²μλ
27λͺ
μ νλμ§μ μ°κ΅¬μμ κ΄μ°° μλ£λ₯Ό λ°νμΌλ‘ λ΄μ©λΆμμ μ€μνμλ€. λ³΄λ€ κ΅¬μ²΄μ μΌλ‘λ μ°Έμ¬ νμ κ°, μ°Έμ¬ νμ-κ΅μ¬ κ°μ μΈμ΄μ νλ λ±μ μνΈμμ©μ μ¬μ΄λ²λΆλ§κ³Ό κ΄λ ¨λ λ΄μ©κ³Ό μ°½μμ λ¬Έμ ν΄κ²°μ κ΄λ ¨λ λ΄μ©μΌλ‘ λλμ΄ λΆμνμλ€. κ·Έ κ²°κ³Ό, μ°Έμ¬ μ²μλ
μ μ 맀λͺ¨νΈν μ¬μ΄λ²λΆλ§ λ¬Έμ λ₯Ό λ³΄λ€ κ΅¬μ²΄μ μΌλ‘ μΈμνκ³ λ€μνκ³ μ κ·Ήμ μΈ ννμ λ¬Έμ ν΄κ²°λ°©μμ μ μν μ μκ² λμλ€. λΏλ§ μλλΌ ν΄κ²°λ°©μμ μ€μνλ λ° μμ΄ μ 체μ μΈ μν©μ κ³ λ €νμ¬ κ΅¬μ²΄μ μΈ μ€μ² λ°©μμ κ³ μνλ λͺ¨μ΅μ 보μλ€. μ°½μμ λ¬Έμ ν΄κ²°μ μμ΄μλ νμ°μ Β·μλ ΄μ μ¬κ³ μ ν₯μμ 보μμΌλ©°, μμ΄λμ΄μ μμ Β·μ§μ μΈ‘λ©΄μ ν₯μμ 보μλ€. μ΄λ₯Ό ν΅ν΄μ μ°Έμ¬ μ²μλ
λ€μ΄ μ°½μμ λ¬Έμ ν΄κ²°μ νμ©νμ¬ μ¬μ΄λ²λΆλ§μ μ§νλ‘κ³ μ°½μμ μΌλ‘ λμν μ μμΌλ¦¬λΌ κΈ°λλλ€. μ΄λ¬ν μ°κ΅¬ κ²°κ³Όμ κΈ°μ΄νμ¬ μ°½μμ λ¬Έμ ν΄κ²°μ νμ©ν μ¬μ΄λ²λΆλ§ μλ°© κ΅μ‘ νλ‘κ·Έλ¨ κ°μ μ¬νμ λν΄ μ μνμλ€.N
Experiences During the Leave of Absence and Their Impact on Growth and Development of College Students
λ³Έ μ°κ΅¬λ ν΄νμ΄λΌλ μλ‘μ΄ νκ²½μμ λνμλ€μ΄ κ²½νν λ€μν νλμ μ΄ν΄λ³΄κ³ , νμλ°λ¬ κ΄μ μμ κ·Έλ¬ν κ²½νμ΄ νμλ€μ μ±μ₯κ³Ό λ°λ¬μ μ΄λ ν μν₯μ λ―ΈμΉλμ§λ₯Ό νμνκ³ μ νμλ€. μμΈ μμ¬ 4λ
μ Aλνμ μ¬ν μ€μΈ ν΄ν κ²½νμ΄ μλ νμ 11λͺ
μ λμμΌλ‘ λ©΄λ΄μ μννμλ€. λ©΄λ΄ λ΄μ©μ λͺ¨λ μ μ¬ν ν, μ£Όμ λΆμ λ°©λ²μ μ μ©νμ¬ λΆμνμλ€. μ°κ΅¬ κ²°κ³Ό, λνμλ€μ ν΄ν μ€ μ§μ , μ¬νμ , μκΈ° μ±μ°°μ κ²½νμ νλ€. ꡬ체μ μΌλ‘ μ§μ κ²½νμ μκΈ°μ£Όλ νμ΅κ³Ό λͺ°μ
, νμ₯ 체νκ³Ό μ§λ‘ μ±μ, κ°λ³ν νμ΅ κ²½νκ³Ό κΈμ μ νμ
μ μ λ±μ΄μλ€. μ§μ κ²½νμ νμλ€μ μ§λ‘ κ°μΉκ΄μ ν립νκ³ μ§λ‘μ±μλμ μν₯μ λ―ΈμΉλ κ²μΌλ‘ λνλ¬λ€. μ¬νμ κ²½νμ λ€μμ± μ΄ν΄μ κ°λ°©μ νλλ₯Ό κΈΈλ λ μΈμ κ΅λ₯, μΆμ λν κ°μΉκ΄κ³Ό μ§λ‘λ₯Ό λ°κΏμ€ λ¬Ένμ λ³ κ²½ν, νμ₯ μ λ¬Έκ° κ΅λ₯μ μ§λ‘ νμ, ν° μ‘°μ§ λ¦¬λ κ²½νκ³Ό μκΈ°ν¨λ₯κ°μ΄λ€. μ΄λ¬ν κ²½νμ ν΅ν΄ νμλ€μ μ¬κ³ λ₯Ό νμ₯νκ³ νμΈμ λν μ΄ν΄κ° λμμ§λ λ± κ°μΉκ΄μ΄ μ¬μ 립 λ κ²μ νμΈν μ μμλ€. μκΈ° μ±μ°°μ κ²½νμ 무기λ ₯μ λ¨μΉκ³ λμ ν΄ λ³Έ κ²½νκ³Ό μμ μ±μ·¨, λμ μ ν΄μΈ κ²½νκ³Ό μ±μν μμκ°λ
, λλ₯Ό λλμλ³Έ μκ°κ³Ό λ΄λ©΄μ μ±μ λ±μ΄ μλ€. μκΈ° μ±μ°°μ κ²½νμ νμλ€ μμ μ λν μ±μ°°κ³Ό μ΄ν΄νλ κ³Όμ μ ν΅ν΄ λ΄μ μ±μμ μ΄μ§νκ³ μμλ€. λ³Έλ‘ μμλ λ³Έ μ°κ΅¬μ κ²°κ³Όκ° μ£Όλ μ΄λ‘ μ ν¨μμ μ μ±
μ μμ¬μ μ μ μνμλ€
Latent Profiles of Internet Use and its Relationship with Cyber Delinquency among South Korean Adolescents
λ³Έ μ°κ΅¬μμλ μ²μλ
λ€μ μΈν°λ· μ¬μ© μ νμ νμΈνκ³ μ΄λ¬ν μ νμ΄ μ¬μ΄λ²λΉν κ°ν΄ λ° νΌν΄μ λ―ΈμΉλ μν₯μ νμΈνκ³ μ νμλ€. μ°κ΅¬λ₯Ό μνμ¬ International Self-Report Delinquency Studyμ 4μ°¨λ
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μ λ€μν μΈν°λ· μ¬μ©μ λνμ¬ μ΄ν΄νκ³ λΉν μ νλ³ λ§μΆ€ κ°μ
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