Dynamic simulation of gas hydrate reservoirs in the Shenhu area,the northern South China Sea

为进一步了解南海北部神狐海域天然气水合物的成藏匹配条件,利用典型二维地震剖面,构建了该区的地质模型,并对其进行了天然气水合物成藏动力学的模拟。研究结果表明:神狐海域具备天然气水合物成藏的温度、压力条件;生物气和热解气的资源潜力巨大,满足水合物形成的气源条件;运移条件优越,有利于天然气水合物的聚集成藏。并提出了该区天然气水合物的成藏模式。The north slope of the South China Sea is structurally characterized by a passive continental margin and has various Cenozoic oil-and gas-bearing depositional basins,where hydrocarbon resources are abundant,and the geological and tectonic settings,the temperature and pressure regimes as well as the methane-generative potential of thick organic-rich sediments are all favorable for the formation of gas hydrate.As a result,this region is also an ideal area for studying gas hydrate accumulations.In order to understand natural conditions of the gas hydrate formation,based on the typical 2-dimensional seismic image of the Shenhu area,a geological model of gas hydrate reservoirs was established and a dynamic simulation of gas hydrate accumulations was carried out as well.The results indicated that the temperature and pressure of the Shenhu area are appropriate for gas hydrate accumulations,source rocks there have a huge gas-generative potential and hydrocarbon migration conditions are favorable,providing an abundant gas source and good pathways for the gas hydrate formation.A forecasting model of the gas hydrate formation was given based on basin analysis,indicating that the Shenhu area is a better prospect area of gas hydrate because of its huge potential of gas hydrate resources.国土资源部公益性行业科研专项(200811014)“天然气水合物成藏的控制因素研究”;国家自然科学基金项目(No.40930845)“南海北部深水盆地油气渗漏系统与天然气水合物富集机制研究”;国家重点基础研究发展规划(973)项目(2009CB219501)“南海北部天然气水合物成藏的气源条件研究”联合资

Y型聚乙二醇干扰素琢-2b注射液治疗HCV基因2/3型慢性丙型肝炎患者疗效和安全性的多中心随机对照试验研究

目的以标准剂量的聚乙二醇干扰素(Peg IFN)α-2a联合利巴韦林作为阳性对照,评价新型试验药物Y型Peg IFNα-2b注射液联合利巴韦林治疗2型/3型慢性丙型肝炎(CHC)患者的疗效和安全性。方法采用多中心、随机开放、阳性药对照的Ⅲ期临床试验,筛选符合要求的2型/3型CHC患者,按照2:1的比例随机分配到Y型Peg IFNα-2b组和Peg IFNα-2a组,同时口服利巴韦林,疗程24 w,停药随访24 w。采用Abbott Real Time HCV Genotype II检测HCV基因型,采用Cobas Taq Man实时定量PCR法检测血清HCV RNA水平。详细记录不良事件。主要疗效指标为持续病毒学应答(SVR),并进行非劣效检验。结果本试验实际入组2型/3型CHC患者255例,实际治疗241例。全分析集(FAS)数据显示,158例试验组和83例对照组患者SVR分别为85.4%(95%CI 79.94%~90.94%)和79.5%(95%CI 70.84%~88.20%,P=0.2402);对符合方案分析集(PPS)人群分析显示,试验组和对照组患者SVR分别为87.9%(95%CI 82.45%~93.27%)和85.9%(95%CI 77.82%~94.01%,P=0.7060),率差的95%可置信区间均符合非劣效标准;对PPS人群分析显示,85.8%受试者获得了早期病毒学应答(RVR),RVR的阳性预测值为90.1%;试验组和对照组不良事件发生率相似,分别为95.6%和95.2%,严重不良事件发生率分别为3.8%和3.6%。结论应用Peg IFNα联合利巴韦林治疗2型/3型CHC患者,新型试验药物Y型Peg IFNα-2b具有与对照药物Peg IFNα-2a相似的疗效和安全性。国家科技部“十二五”重大专项(编号:2012ZX10002-003)；“重大新药创制”十二五科技重大专项(编号:2012ZX09303019)

南海北部陆坡神狐海域天然气水合物成藏的流体运移体系

通过新近纪断裂体系和底辟构造特征综合分析认为，底辟构造、高角度的断裂和垂向裂隙系统构成了南海北部神狐海域天然气水合物成城的主要流体运移体系．神狐海域断层发育，可分为晚中新世活动的NW（NNW）向断层和上新世以来活动的NE（NNE）断层曲组．NE向断层活动强度小，规模大，从下至上切穿上新世以来沉积层，组成高角度断裂和垂向裂隙系统．底辟构造在地震剖面上呈直立的、上小下大的烟囱状通道，局部横向扩张呈囊状、花状，形成大型的反射模糊带．底辟构造的发育在上覆沉积层产生了树枝状、似花状组合形态的高角度断裂和垂向裂隙系统，构成了良好的流体运移通道和疏导体系．当富含甲烷气体的流体通过底辟构造、断裂及裂隙系统垂向或侧向运移时，在合适的温压条件下形成天然气水合物