高校新型官产学研合作平台研究——以厦门大学深圳研究院为例

“官产学研“合作是政府、高校、科研院所、企业以共同发展目标为基础,按照一定的机制和规则,将彼此的资源有效融合,实现多方共赢的联盟。本研究通过运用SWOT分析法对高校新型“官产学研“合作平台的案例研究、战略分析,归纳总结我国高校新型“官产学研“合作平台的优点、缺点、机遇和挑战,提出可资借鉴的战略调整对策,具有较强的理论价值和实践意义

Ultrasound Guided Percutaneous PDT For Advanced Liver Cancer A Report of 30 Cases

为探讨治疗中晚期肝癌的理想方法，扩大和发展光动力疗法，自1994年6月起，我们应用光动力疗法（PdT）治疗中晚期肝癌30例，其中肝细胞癌28例、腺癌2例。肿瘤直径7~10CM的13例、10CM以上至16CM的17例。伴肺转移5例、骨转移5例、门静脉或腔静脉浸润4例。首次治疗19例、其他方法治疗无效或复发者11例。本研究采用氩激光泵浦染料激光器系统，获得630nM波长的连续波治疗光。光敏剂选用血卟啉衍生物（HPd）。治疗时通过b超引导经皮肝穿，将光纤导入肿瘤组织中布点照射。治疗后未见肝功能明显损伤，未出现肝穿出血、腹膜炎等严重并发症，没有一个月内病情恶化者。有14例患者只作一次治疗，其中5例出院后失访；另9例肿瘤部分缓解率为22%。16例患者接受二、三次治疗，肿瘤部分缓解率达到62%。随访病例中有8例已存活1年以上。patients with advanced liver cancer were treated by interstitial photodynamic therapy (PDT).These included 28 hepatocellular carcinoma and two adenocarcinoma, 19 primary tumors and 11 recurred Following other treatments.The diameter of tumors were 7 10 cm in 13 cases and 10 16 cm in 17 cases.In this study, an argon laser pumped dye laser system was used to give a CW laser beam at 630 nm which was split and coupled into three optical Fibers.The patients received injection of photosensitizer of hematoporphyrin derivative (HpD) i.v.at a dose of 5 mg/kg body weight 48 h prior to laser irradiation.Then the Fibers were inserted into tumor by ultrasonic visualization guided percutaneous liver puncture.The inserted irradiation points were spaced in entire tumor volume and the tumor was irradiated with a light output power of 300 mW For 12 minuts per point.Totally 52 treatments were perFormed in 30 patients.Among them, 14 cases were treated by only one time and 16 cases 2 or 3 times.The Follow up were carried out in 25 cases For 3 18 months.The results show that signiFicant remission was 22% (2/9) in those patients by only one treatment and 62% (10/16) in those by 2 or 3 treatments.The reduction rate of tumor size was over 90% in Five out of six cases aFter 3 treatments.8 patients have been surviving over one year.No obvious change was Found in all patients examined by liver Function test, renal Function test and blood routine examination.The level of AFP depicted a descending tendency aFter PDT.Our Findings indicate that PDT is eFFective and saFe For the treatment of large liver cancers including those recurred Following hepatic resection and those Failed in hepatic artery inFusion embolic chemotherapy.福建省“八五”攻关资

Application of Interstitial Photodynamic Therapy For Liver Cancer under Real time US Guidance

报道30例超声引导间质性激光动力学疗法（InTErSTITIAlPHOTOdynAMICTHErAPy，IPdT）治疗中晚期肝癌新方法的临床应用结果，旨在评价其临床应用价值。采用氩激光泵浦染料激光器，获得630nM波长的连续治疗光，光敏剂选用血卟啉衍生物（HPd），于超声引导下将光纤导入肿瘤组织内进行间质性照射。结果表明：1有14例患者仅行一次治疗（其中5例失访），肿瘤部分缓解率为22%，16例患者接受2~3次治疗，肿瘤部分缓解率达62%。随访病例中已有8例存活一年以上。2所有病例未见严重并发症。这种治疗方法是一种有效而安全的治疗肝癌新方法。To evaluate the eFFicacy of interstitial photodynamic therapy (IPDT) For liver cancer, 30 patients with liver cancer were treated with IPDT under US guidance.An argon laser pumped dye laser system was used to give a CW laser beam at 630 nm.The patients were injected intravenously with photosensitizer hematoporphyrin derivative (HpD) at a dose of 5 mg/kg body weight 48 h beFore IPDT.Then the optical Fibers were inserted into tumor under ultrasound guidance, the tumors were irradiated with CW laser.Clinical results showed that ①14 cases were treated only one time, the partial remission rate of the tumor was 22%, 16 cases were treated by 2￣3 times, the partial remission rate of tumors was 62%.In 8 cases the survival time was over one year; ②No severe complication and side reaction were Found aFter IPDT in this series.It is suggested that IPDT is a saFe and eFFective new method For treatment of liver cancer.福建省“八五”攻关基