跨海通道的大跨度公铁两用斜拉桥研究

跨海大桥是最需要考虑节约资源和进行环境保护的桥梁。而大跨度公铁两用斜拉桥是目前占用跨海通道资源最少的大桥,也是跨海大桥设计的首选桥型。在广泛调研跨海大桥和收集文献资料的基础上,对我国近年来修建的跨海大桥进行了梳理统计,发现我国已经建设的公路跨海大桥大部分的主航道桥是斜拉桥。对部分国内外大跨度公铁两用斜拉桥的结构设计关键技术进行了论述;结合大跨度公铁两用斜拉桥的结构特点,对适用于大跨度公铁两用斜拉桥的结构体系和桥面布置进行了对比分析;提出了影响公铁两用斜拉桥跨度增大的问题与对策;还针对跨海通道的公铁两用斜拉桥的设计寿命大于100 年,在要求跨海桥梁设计安全可靠经济美观的同时,还要在运营阶段得到妥善的养护维修,才能实现耐久性与可持续发展的目标。因此对大跨度公铁两用斜拉桥的钢梁和钢斜拉索的耐久性进行了分析研究。研究结果可为同类型跨海大桥的设计提供一定的技术参考

Establishment of a nude mouse model of glioma orthotopic xenograft with double-fluorescent labeling

目的建立一种稳定、可实时监测的胶质瘤原位移植瘤裸鼠模型。方法用带有荧光素酶（luciferase-Luc）和绿色荧光蛋白（green fluorescent protein-GFP）基因的慢病毒感染U251神经胶质瘤细胞,流式细胞仪筛选稳定表达GFP-Luc荧光的细胞系,并通过CCK-8实验、细胞周期实验、Transwell肿瘤迁移及侵袭实验等评价荧光细胞的增殖、迁移和侵袭能力是否改变;将细胞接种至裸鼠大脑尾状核,建立胶质瘤原位移植瘤模型,利用小鼠活体成像系统监测脑内肿瘤的生长情况,并通过石蜡切片,HE染色评价细胞在裸鼠脑内的病理特征及成瘤能力。结果成功构建稳定表达GFP荧光和luciferase荧光的U251胶质瘤细胞系及动物模型,慢病毒整合并未改变细胞的增殖、迁移及侵袭能力;模型生长周期适中,成瘤率高,瘤体在颅内生长稳定,HE切片符合人胶质瘤特征。结论双荧光标记的胶质瘤细胞相比于传统细胞更有利于胶质瘤动物模型的实验研究;U251-GFP-Luc胶质瘤细胞裸鼠模型,其肿瘤生长和病理特性与人胶质瘤相似,且可实时观察肿瘤生长,可作为胶质瘤实验研究的理想动物模型。Objective To establish a stable and real-time monitorable nude mouse model of orthotopic glioma xenograft. Methods U251 glioma cell line was infected by a leutiviral vector containing green fluorescent protein （GFP） and luciferase （Luc） gene. Ceils stably expressing fluorescence of GFP and Luc were sorted by flow cytometry. CCK-8 test and Transwell tumor invasion and migration assay were used to compare the biological features between the ceils stably expressing GFP-Luc fluorescence and cells without fluorescence. Then the ceils were implanted intracranially in the right caudate nucleus of athymic BaIb/c nude mice to establish the tumor model. The growth of intracerebral tumor was monitored over time by a bioluminescence imaging （BLI） system. Hematoxylin-eosin （HE） staining was used to evaluatethe histopathological features and tumorigenicity of the transplanted glioma cells in the brain of nude mice. Results U251 glioma cell line with stably expressing GFP-Luc fluorescence and the corresponding orthotopic xenograft model were successfully established. There was no statistically significant difference in the proliferation, invasion and migration abilities between the cells with stably expressing GFP-Luc fluorescence and the control cells. This model showed a high tumor formation rate and stable tumor growth, and takes a moderate time to establish this model. Conclusions Compared with the traditional glioma cells, GFP-Luc-transfected human glioma cells are more feasible for the studies of glioma in vivo. The tumor growth and pathological characteristics in this U251-GFP-Luc glioma model are similar to human glioma, and the growth of this tumor can be real-time monitored. It can be used as an ideal animal model for experimental studies of glioma.国家自然科学基金（编号：30970733）

Research Progress of Silicon-Based Spin Injection

自旋注入、自旋探测和自旋操控是构建半导体自旋电子器件的基础。在硅基材料上采用电的方式进行自旋注入,有利于自旋器件与微电子芯片的集成化,是当前该领域的研究热点课题之一。简要概述了硅基自旋注入的研究进展,首先介绍了半导体自旋注入的原理和方法,着重评述了以磁隧道结(MTJ)结构为核心的硅基自旋注入的研究进程,然后详细论述了硅基自旋注入的测试原理、器件结构和实验方法,最后给出了硅基自旋注入的主要研究目标和发展方向,并展望了硅基自旋电子器件的前景。The spin injection,spin detection and spin manipulation in semiconductor are the foundation for building spintronic devices.The silicon-based materials using electrical methods to spin injection can be beneficial to the integration of microelectronic chip with spintronic devices,and which is one of hot topics of research in this field.The research progress of the silicon-based spin injection is summarized briefly.The principle and method of the spin injection for semiconductors are introduced firstly.And then the research progress of silicon-based spin injection with magnetic tunnel junction( MTJ) as the core structure is reviewed.After that,the test principle,device structure and experimental method of silicon-based spin injection are discussed in detail.Finally,the main direction and research goal of silicon-based spin injection are pointed out,and the outlook of silicon-based spintronic devices is prospected.国家自然科学基金资助项目(61176092); 国家自然科学青年基金资助项目(11104232); 陇原青年创新人才扶持计

电场驱动HgCdTe/CdTe量子阱拓扑相变引起的光吸收增强研究

HgTe/CdTe量子阱是研究拓扑绝缘体新奇物性的一个很好载体。采用Kane八带k·p模型,对电场驱动Hg1-xCdxTe/CdTe量子阱拓扑相变及其相变前后的光吸收性质进行了研究,并使用BHZ模型对吸收系数进行了解析计算和分析。结果表明:在电场能够驱动Hg1-xCdxTe/CdTe量子阱拓扑相变后继续增大电场,其能带可变为墨西哥帽形状,联合态密度将会增强,导致光吸收相比于无电场时显著增强,与解析计算结果相吻合。对于平行界面偏振光(TE)吸收曲线在带边还形成了双峰结构。文章结果可用于新型红外光电探测器、激光器以及频率选择器等量子阱器件的研究和设计。福建省自然科学基金项目(2016J05163);;中央高校基本科研业务费专项资金项目(20720160019

STUDY ON THE MORPHOLOGY AND ULTRASTRUCTURE of THE INNER EAR of OREOCHROMIS SP.

罗非鱼内耳器官结构与典型硬骨鱼的内耳结构一致。球状囊呈椭圆体状，其耳五充满整个囊体，耳石上有明显的中央沟，中央沟在形态上与球状囊听斑一致；听囊呈圆形，听囊耳五约占整个听囊一半，耳石较薄且较透明，有明显外缘区和中央区之分；椭圆囊呈不规则椭球体状，其耳石占椭圆囊的较小部分，耳石表面粗糙。罗非鱼耳石膜为一层胶质膜，位于耳石和听斑之间，并触及所有毛细胞，膜有大量小孔，小孔处恰为毛细胞的纤毛束伸入，纤毛束透过小孔触及到耳石。扫描电镜观察表明，罗非鱼内耳听斑也由毛细胞和支持细胞组成，听斑表面有大量具一定分布规律的纤毛束。罗非鱼内耳听觉器官主要有三种纤毛束类型：f＿1、f＿2和f＿3型。按照纤毛束的取向一致性，球状囊听斑划分三个区；听囊听斑和椭圆囊听斑均划分两个区。This paper deals with the morphological structure of the inner ear of anonostariophysine Fish, Oreochromis sp,From the lake of Xiamen University,using light andscanning electron microscopy.The results are as Follows;1.The structure of the ear in Oreochromis sp.is the same as that of“the typical teleostear”.which consists of three semicircular canals(anterior,posterior and horizontalsemicircular canals)and three otolithic organs(utriculs,lagena and sacculus).Each Fish hastwo ears between which no connection was obesrved.The bilateral mirror symmbtry of eachsaccular pair often involves divergence of the anterior ends 25-30°away From thebody-midline.2.The sacculus is particularly large and utricular-shaped, with a single large otolith Fil-ling the whole otolithic sac,The saccular otolith is a laterally Flattened elipsoid with a deepmedial sulcus with which the sensory epithelium is closely connected.The lagena is generallysmall and round in shape with a small and thin triangular otolith Filling only halF of thesacculus.The utriculus is irregular in shape.The utricular otolith is also small and has roughsurFace,Filling only a small part of the sacculus;3.The otolithic membrane is a thin gelatinous structure lying between the macula andthe otolith,contacting all the sensory cellshcluding those in regions not directly“undcF”theotolith.The membrane has a large number of small holes where the ciliary bunddles extendand contact the otolith.4.The results of scanning electron microscopy reveal that the maculae consist of sensoryeells and supporting cells and the surFace of the sensory epithelia of each of the otolithic or-gans is distributed with a lot of ciliary bundles in a certain pattern.There are mainly threetypes of three ciliary bundle F_1, F_2 and F_3.in the inner ear organs of the Oreochromissp.Each otolithic macula can be divided into a number of regions within which all the ciliarybundles are morphologically polarized in the same two in lagenar macula and two in utricularmacula,Morphologically,the utricular macula is dish-shaped and has a lateral extension,the lagenar macula is the shape of a Fat crescent and the saccular macula is elongate but widerat the rostral than the caudal end, like the shape of a tadpole.国家自然科学基

1．55μm Si基光电探测器的研究进展

从材料的生长、器件结构的选择等方面对1．55μm锗光电探测器的研究进展进行了综述，对Ge量子点共振腔增强型光电探测器的应用前景进行了探讨与展望

中国地震预报论坛2019年学术交流在青海海东举办

中国地震学会地震预报专业委员会与中国科学院力学研究所和青海省地震局于2019年8月26—28日在青海海东市联合举办了中国地震预报论坛2019年学术交流会。来自全国行业内外的150名代表参加了此次学术交流。大会设置了8个专题;共交流报告50篇,其中,口头报告30篇,张贴展板20篇;30篇口头报告中,特邀口头报告9篇,行业系统外口头报告7篇,行业内雏鹰报告9篇。除了一贯的最佳张贴报告评选之外,大会还对张贴报告首次设立了最佳创意奖,对雏鹰报告设置了最佳形象奖。大会按照惯例举行了Panel讨论,针对大地震的物理机制以及预测地震所依赖的观测技术展开了积极的讨论。大会学术交流之后举办了关于地震滑坡灾害的实体科普调研活动。本次论坛会前征集到论文摘要142篇。针对特别设立的宜宾地震专题,快速征集到摘要8篇,分别涉及前震识别、震源机制解析、孕震构造环境、动力学条件、视应力变化与电离层异常等。全部论文摘要集在《国际地震动态》第8期刊出。《高原地震》和《地震》分别出版了部分报告的全文