我院抗肿瘤药物和全静脉营养液不合理医嘱原因分析

收集我院静脉用药调配中心2013年1月至2014年3月间药师审核的抗肿瘤药物和全静脉营养液的医嘱,对其中不合理用药问题进行整理、归纳和总结,并提出合理化建议。审核的17683组医嘱中,存在不合理用药的医嘱有163组,占0.922%。不合理用药主要表现为:不合理的溶媒使用量、不合理的药物剂量、医生疏忽导致的用药错误、不合理的用药持续时间、不合理的给药途径、不合理的用药配伍和选择、肠外营养液组方中能量配比不合理

1例胃癌患者化疗后呕吐的病例分析

通过1例胃癌患者化疗后呕吐的药物治疗过程,阐述癌症患者呕吐的各种原因及目前治疗呕吐的各种方法。该名患者在尝试目前几乎所有的止吐方法后症状仍无法得到有效改善,因此医务人员探寻新的止吐方法对于改善晚期肿瘤患者的生活质量显得尤为重要

1例胃癌患者化疗后呕吐的病例分析

通过1例胃癌患者化疗后呕吐的药物治疗过程,阐述癌症患者呕吐的各种原因及目前治疗呕吐的各种方法。该名患者在尝试目前几乎所有的止吐方法后症状仍无法得到有效改善,因此医务人员探寻新的止吐方法对于改善晚期肿瘤患者的生活质量显得尤为重要

Therapeutic Efficacy of Itraconazole versus Fluconazole in the Treatment of Vulvovaginal Candidiasis:A Meta-analysis

目的:系统评价伊曲康唑对比氟康唑治疗单纯性外阴阴道念珠菌病(VVC)的临床疗效,以为临床提供循证参考。方法:计算机检索PubMEd、EMbASE、MEdlInE、THE COCHrAnE lIbrAry、中文科技期刊数据库、中国期刊全文数据库、万方数据库,收集伊曲康唑对比氟康唑治疗单纯性VVC的随机对照试验(rCT),提取资料后采用rEV MAn 5.2统计软件进行META分析。结果:纳入7项rCT,合计1 006例患者。META分析结果显示,氟康唑组患者总治愈率[Or=0.50,95%CI(0.32,0.79),P=0.003]、第一阶段随访的真菌学治愈率高于伊曲康唑组[Or=0.61,95%CI(0.42,0.89),P=0.01],两组比较差异有统计学意义;两组患者临床治愈率、第二阶段随访的真菌学治愈率以及复发率比较差异无统计学意义。结论:氟康唑治疗单纯性VVC的疗效优于伊曲康唑,可以提高患者的总治愈率和第一阶段随访的真菌学治愈率。由于纳入研究数量较少、质量偏低,该结论尚需大样本、高质量的rCT进一步证实。OBJECTIVE:To evaluate the clinical efficacy of itraconazole versus fluconazol in the treatment of simple vulvovaginal candidiasis(VVC) systematically and to provide evidence-based reference for clinical use.METHODS:Retrieved from PubMed,EMBase,Medline,The Cochrane Library,VIP,CNKI and Wanfang database,RCT about itraconazole versus fluconazol in the treatment of simple VVC were collected,and Meta-analysis was conducted by using Rev Man 5.2 statistical software after extracting data.RESULTS:A total of 7 RCT were included,involving 1 006 patients.Meta-analysis showed that total cure rate[OR=0.50,95%CI(0.32,0.79),P=0.003] and 1st microbiological cure rate [OR=0.61,95%CI(0.42,0.89),P=0.01] of control group were higher than trial group;there was statistical significance;there was no significant difference in cure rate,2nd microbiological cure rate and recurrence rate between 2 groups.CONCLUSIONS:Itraconazole maybe perform better than fluconazole in the treatment of simple VVC,and can improve cure rate and 1st microbiological cure rate.Due to small-scale and low-quality included studies,the conclusion should be further validated by large-scale and high-quality RCTs.国家科技支撑计划子课题(No.2013BAI06B04Y023081