Progress in Chiral Sensors

手性工程的崛起对简单、经济、快速、实时、在线的手性检测技术提出了挑战。手性传感器是一个重要的发展趋势。本文综述了近年来在手性电化学传感器、基于石英晶体微天平的手性质量化学传感器及手性光学传感器方面的研究进展,重点介绍了各种传感器的制备及其在手性检测中的应用,并展望了该领域的发展前景。The development of chiral engineering requires chiral analytical technologies with simple handling,low cost,high speed,real time and on-line operation.Chiral sensor system represents a major branch of future research.In this paper,the progress in chiral electrochemical sensor,chiral mass chemical sensor based on quartz crystal microbalance and chiral optical sensor is reviewed.The preparations and applications of these chiral sensors are introduced.The prospects of this field are also put forward.福建省自然科学基金项目(No.C0540024);; 福建省教育厅课题(No.JA05301)资

Thermodynamic Studies on Mechanism of Chiral Resolution by Liquid Chromatography

手性识别是分子识别的一个重要组成部分。液相色谱手性拆分机理研究有助于色谱条件的优化和新型手性固定相的设计,也有助于理解手性识别机制。本文就线性色谱与非线性色谱条件下手性拆分过程对应热力学参数的推求方法进行了评述,阐述了相关热力学参数的涵义及其在色谱保留及手性拆分机理探讨中的应用,并展望了该领域的研究前景。Chiral recognition is an important part of molecular recognition.Studies of mechanistic aspects of chiral resolution by liquid chromatography are helpful to optimize chromatographic conditions,to design novel chiral stationary phases and to understand chiral recogniton mechanisms.In this paper,the methodologies for deriving corresponding thermodynamic parameters in the chiral resolution processes by linear or nonlinear chromatography are reviewed.The meaning of correlative parameters is explained.The applications of these parameters in the studies of mechanistic aspects of retentions and chiral resolutions by liquid chromatography are expatiated,and corresponding research prospects are put forward.福建省自然科学基金(No.C0540024);; 福建省教育厅课题(No.JA05301)资

Thermodynamic studies on mechanism of chiral resolution by liquid chromatography

Chiral recognition is an important part of molecular recognition. Studies of mechanistic aspects of chiral resolution by liquid chromatography are helpful to optimize chromatographic conditions, to design novel chiral stationary phases and to understand chiral recogniton mechanisms. In this paper, the methodologies for deriving corresponding thermodynamic parameters in the chiral resolution processes by linear or nonlinear chromatography are reviewed. The meaning of correlative parameters is explained. The applications of these parameters in the studies of mechanistic aspects of retentions and chiral resolutions by liquid chromatography are expatiated, and corresponding research prospects are put forward