Late Quaternary Sediment Stratigraphy and Marine Cycles in the Pingtan Island, Fujian Province

选择位于福建平潭岛北部芦洋埔海积平原的PT01钻孔,岩芯长度28.3 m,采用加速器碳同位素(AMS 14C)和光释光(OSL)测年建立地层年代框架,认为晚更新世富含有孔虫等海相生物化石的地层应归属于MIS 5高海面期,即MIS 5e的潮下带滨海相沉积。结合岩性特征、古生物化石、沉积物色度、粒度分析及其参数等指标,进行了沉积单元的划分,重建了MIS 6末期以来的沉积相变化过程,揭示出MIS 5期间的多次海平面波动变化,即MIS 5高海面期沉积环境仍存在滨海、潮坪、潟湖、风成砂等沉积相之间的转换,并可能存在短暂的陆相或风化过程。而该区整个末次冰期的沉积缺失或较薄,上部全新世沉积也不发育,厚度仅为3.79 m,以沼泽相―风成砂相为主。A 28.3 m long core, PT01, from the Pingtan Island, Southeast China, is selected to be studied. Radiocarbon dating(AMS 14C) and optical stimulated luminescene(OSL) are used for establishing chronology. Combining age-dating results with marine microfossil and color index, we classify the Late Quaternary sediment stratigraphy in the coastal region of Fujian Province. It is suggested that the late Pleistocene marine deposit, dated back to 124 ka, and abundant marine microfossil(e.g. foraminifer and ostracods), would belong to the Marine Isotope Stages 5(MIS 5). Moreover, the late Quaternary sediment could be divided into three units based on the analysis of lithology, microfossil, grain size and color index. Our results reveal that the sediment environment during the MIS 5 was significantly controlled by global sea level change which varied among coast, tidal flat, lagoon, and eolian sand, and probably there existed weathering process. A hiatus during the last glacial(MIS 2-4) was attributed to low relative sea level. And the Holocene deposit, as thick as 3.79 m, developed poorly and was mainly comprised of swamp facies and eolian dune.国家自然科学基金(41230101、41072128

基于改进自编码器的文本分类算法

词的向量化表达是文本挖掘应用的必要前提。为了改善自编码器在词嵌入中的效果,提高文本分类的准确性,提出了一种改进的自编码器并将其用于文本分类。在传统自编码器的基础上,在隐藏层加入了一个全局调整函数,其将绝对值小的特征值调整到绝对值大的特征值上,实现了隐藏层特征向量的稀疏化。得到调整后的特征向量之后,采用全连接神经网络进行文本分类。在20news数据集上的实验结果表明,所提方法具有更好的词向量嵌入式效果,并且在文本分类中也具有更好的效果。赛尔网络下一代互联网技术创新项目(NGII20160410)资

Two New Compounds Isolated from A Seaweed-associated Fungus, Aspergillus sp. AF044

目的:研究海藻真菌 ASPErgIlluS SP. Af044 的化学成分。方法:通过色谱层析柱对提取物进行分离纯化, 并通过波谱解析(一维、二维的核磁共振谱和质谱)确定化合物的结构。结果:分离纯化得到3个化合物, 分别鉴定为6-HydrOXy-5-METHOXy- 3-METHyl-3, 6-dIHydrO-2H-PyrAn-4-CArbOXylIC ACId (1), 8, 9-dIHydrOXy-8, 9-dEOXyASPyrOnE(2) And PEnICIllIC ACId(3)。结论:化合物 1和 2 是首次发现的新化合物。化合物 3 在多种真菌菌株中分离得到。] AIM: To study the chemical constituents of the seaweed fungus Aspergillus sp.AF044.METHODS: The fermentation extract was isolated and purified by column chromatography (MPLC, Sephadex LH-20, normal Si gel).RESULTS: Three compounds (1 - 3) were isolated and determined as 6-hydroxy-5-methoxy-3-methyl-3, 6-dihydro-2H-pyran-4-carboxylic acid (1), 8, 9-dihydroxy-8, 9-deoxyaspyrone (2) and penicillic acid (3) based on their spectral data (1H, 13C, HMQC, HMBC, 1H-1H COSY and NOE).CONCLUSION: 1 and 2 are new compounds; Penicillic acid was isolated from many fungi.ThisprojectwassupportedtheKeyGrantofChineseMinistryofEducation(No.306010)---

Effects of a combination therapy with a compound Chinese medicine and an enteral nutrition powder in the treatment of mice with chronic obstructive pulmonary diseases

目的 评估健脾益气复方中药颗粒剂联合肠内营养粉剂安素治疗慢性阻塞性肺疾病（COPD）的有效性与安全性。方法 选取雄性小鼠96只,其中24只作为正常对照组,其余72只采用烟熏小鼠法建立COPD模型,随机分3组：COPD模型组、安素治疗组（0.558 g/m L安素,0.1 m L/10 g小鼠）及中药联合安素治疗组（0.558 g/m L安素,0.1 m L/10 g小鼠＋2.5 g/m L中药,0.06 m L/10 g小鼠）。所有小鼠在实验全程进行体重监测,并分别在治疗前、治疗后2周及5周进行血清学检测及肺组织切片检查。结果 与正常对照组小鼠相比,COPD模型组小鼠体重增加明显减缓,血清总蛋白和白蛋白含量均明显降低（P〈0.05）,血清谷草转氨酶和谷丙转氨酶含量均明显升高（P〈0.05）。与COPD模型组小鼠相比,中药联合安素治疗组小鼠的体重明显回升,治疗后5周,血清总蛋白和白蛋白含量均显著增加（P〈0.05）,血清谷草转氨酶和谷丙转氨酶含量均明显下降（P〈0.05）。病理切片结果也证实了中药联合安素治疗对COPD肺部病理改变具有明显改善作用。结论 健脾益气复方中药联合肠内营养粉剂安素可明显改善COPD营养不良状况,并有效改善其肺组织受损情况。Objective To evaluate the validity and safety of a combination therapy with a compound Chinese medicine and an enteral nutrition powder ensure on chronic obstructive pulmonary diseases （COPD）. Methods Among 96 male mice, 24 mice were randomly selected as a normal control group, the other 72 mice were induced as COPD mice after 60-day smoking. These COPD mice were then randomly divided into 3 groups： COPD positive group, Ensure treatment group （0.558 g/mL Ensure, 0.1 mL/10 g mice）, combina- tion therapy group （0.558 g/mL Ensure, 0.1 mL/10 g mice＋2.5 g/mL traditional Chinese medicin, 0.06 mL/10 g mice）. The weights of all mice were monitored during the whole experimental period. The serologic tests were carried out before and at different time points （2 weeks or 5 weeks） after the treatments began. Meanwhile, histological examinations of their lungs were performed. Results Compared with the normal control group mice, COPD mice showed a lower amount of serum albumin （P 〈 0.05） and a higher level of serum aminotransferase activity （P 〈 0.05） with a much slower rate in weight gaining. After 5-week treatments with the combination albumin were increased gradually （P 〈 0.05） therapy, compared with the COPD positive group, the amounts of serum and the serum aminotransferase activities were returned to normal （P 〈 0.05）. Results from histological examinations confirmed the efficacy of the combination therapy on COPD mice. Conclusion The combination therapy with a compound Chinese medicine and an enteral nutrition Ensure is effective in improvement of poor nutrition status in COPD mice induced by smoking, and effectively improve the lung tissue damage.福建省福州市卫生系统科技计划项目（2014-S-W29）;福建省福州市科技计划项目（2015-S-141-4）;福建省福州经济技术开发区科技计划项目（2015mw08）

藻类影响虾池若干水质因子初探

本文在分析几口虾池藻类的种类与数量的同时,检测了这些虾池的几种生态因子(PH、dO、比重和nH_3—n),并结合室内小水体模拟实验,讨论了浮游植物的种类与数量对养殖虾池生态的影响。结果认为,以硅藻(如骨条藻和角毛藻等)或绿藻(如小球藻等)为优势的虾池,养殖生态较稳定,对虾养殖状况较好

The correlation between body mass index,waist-to-hip ratio,waist circumference chronic hepatitis B with nonalcoholic fatty liver diseases

目的探讨体质量指数(bMI)、腰臀比(WHr)与慢性乙型肝炎(CHb)并非酒精性脂肪性肝病(nAfld)的相关性。方法研究对象为厦门大学附属东南医院肝病中心住院的110例nAfld患者和143例CHb并nAfld患者,选取同期健康体检者23例为对照组。采用方差分析(AnOVA)、bOnfErrOnI法,比较三组间bMI、WHr、腰围(WC)、空腹血糖(fbg)、胆固醇(TCHO)、甘油三酯(Tg)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(AlT)、碱性磷酸酶(AlP)、谷氨酰转移酶(ggT)的差别,分析各项指标与CHb并nAfld的相关性。结果与对照组相比,nAfld组和CHb并nAfld组的bMI、WHr、WC、Tg、AST、AlT、ggT水平均显著增加(P0.05)。结论 CHb并nAfld患者的发病机制与血脂紊乱相关,尤其是高Tg血症,临床中监测WHr与WC有助于CHb并nAfld的早期诊断。Objective To explore the correlation between body mass index (BMI),waist to hip ratio (WHR) and chronic hepatitis B (CHB) patients with nonalcoholic fatty liver diseases (NAFLD).Methods A total of 110 subjects with NAFLD and 143 CHB patients with NAFLD were enrolled in Dongnan Affiliated Hospital of Xiamen University,and 23 normal subjects were selected as control group.Differences of BMI,WHR,waist circumference (WC),fasting plasma glucose (FPG),total cholesterol (TCHO),triglyceride (TG),aspartate aminotransferase (AST),alanine aminotransferase (ALT),alkaline phosphatase (ALP),gamma-glutamyl transpeptidase (GGT) among three groups were analyzed by ANOVA and Bonferroni correction methods.Results Compared with the control group,the levels of BMI,WHR,WC,TG,AST,ALT,GGT were significantly higher in CHB patients with NAFLD and NAFLD patients (P< 0.05).WHR and WC of NAFLD patients were higher than that of CHB patients with NAFLD.There was no significant difference in other indexes.Conclusions The hepatic steatosis changes in CHB patients with NAFLD are mainly caused by the metabolic factors.WHR and WC may be helpful for early diagnosis in CHB patients with NAFLD.福建省漳州市科技计划资助项目(No.Z04094

非活动性HBsAg携带者并妊娠期急性脂肪肝一例报道

妊娠急性脂肪肝(ACuTE fATTy lIVEr Of PrEgnAnCy,AflP)多发生于妊娠28~40周,临床上并不少见,近年报道该病例有增多趋势[1];AflP起病急、病势凶险,病死率及早期诊断与治疗措施密切相关;随着乙肝疫苗的广泛接种,我国HbSAg阳性率显著降低,但仍高达7.18%[1],育龄期孕妇HbSAg阳性率达8.16%[2],高于普通人群的HbSAg阳性率,非活动性HbSAg携带者并AflP临床上较为少见,本文报道1例如下。一、病历摘要患者,女,20岁,因“停经24周,乏力

慢性乙型肝炎伴劳-蒙-毕综合征1例

患者,男性,10岁,因“乏力、食欲不振、尿黄8月余“于2010年5月入院。患儿父母诉患儿自幼双手六指畸形,右侧隐睾,于3岁时曾行左侧畸形手指矫正术,7岁发现智力落后于同龄儿、生长缓慢,9岁行右侧睾丸复位固定术。患者为第1胎第1产,父母非近亲结婚,母孕期间曾有“上呼吸道感染“病史,否认家族中有其他遗传病病史

妊娠急性脂肪肝2例报告

病例1:女,27岁。停经36周伴瘙痒、呕吐、腹泻、尿少15 d。查体:皮肤、巩膜重度黄染,未见肝掌、蜘蛛痣,静脉穿刺部位片状瘀斑、心率86次/MIn、律齐、未闻及杂音,双下肺闻及少许干湿啰音;腹部膨隆,双下肢轻度水肿。实验室检查:血常规:WbC 18.65x109/l、n 0.885、PlT 82x109/l;生化:glu 3.6 MMOl/l、urEA 8.16 MMOl/l、r