从磷酰化氨基酸到丝组二肽

磷是重要的生命元素之一,参与生命活动的各种生化反应进程。L-氨基酸是组成蛋白质的基本结构单元,氨基酸的N-磷酸化,使氨基酸分子被激活,成为一种"微型活化酶",可以发生多种生化反应,比如成肽反应。丝组二肽(L-丝氨酰-L-组氨酸)就是在N-磷酸化氨基酸的成肽反应过程中产生,并发现是具有多种生物酶活性的最小的功能肽,是现代水解酶的原始进化雏形。本文详细回顾了从N-磷酸化氨基酸到丝组二肽发现的研究历程,有痛苦、有迷茫,也有欢喜,充分体现了科学探索的魅力所在

磷化学与化工进展

磷是一种不可更新、难以替代的资源,磷的资源危机将对我国社会可持续发展乃至人类的生存构成严重威胁.以现在的开采和使用速度,世界的磷资源将在50年后面临枯竭,而我国的磷资源将在20年后出现危机.近些年来,国际磷肥价格持续增长,同时,磷矿资源所具有的战略意义也正日益显现.一些研究人员认为,在今后几十年中,随着全球高质量的

分子进化的基本化学规律

N-磷酰 - α-氨基酸在水或有机溶剂中可以同时自组装生成肽及核苷酸 ,而 β-氨基酸或 γ-氨基酸在同样条件下则不发生任何反应 .这种分子结构的特征是由磷化学的特性所决定的 .五配位磷化合物对 α-氨基酸及核糖具有专一的化学选择性 ,这种化学选择性推动了自然选择

丙氨酰-谷氨酰胺二肽合成工艺研究进展

目的:为丙氨酰-谷氨酰胺二肽(Ala-Gln)类药物的进一步研究和生产提供参考。方法:以\"丙氨酰-谷氨酰胺二肽\"\"合成工艺\"\"谷氨酸水解法\"\"D-氯(溴)代丙酸法\"\"N-羧基内酸酐法\"\"活化酯法\"\"三苯基膦/六氯乙烷缩合法\"\"Ala-Gln peptides drugs\"\"Synthetic process\"\"Appel condensation method\"等为关键词,组合查询在中国知网、Web of Science等数据库中收录的1987年1月-2017年12月发表的相关研究文献,进行归纳和总结。结果与结论:共检索到相关研究文献678篇,其中有效文献25篇。Ala-Gln以往的合成方法主要有谷氨酸水解法、D-氯(溴)代丙酸法、N-羧基内酸酐法、活化酯法、酶催化合成法等,这些方法存在步骤烦琐、反应成本高、带有毒性、合成路线长、大批量生产的产率难以控制等缺点,严重制约了其推广应用。三苯基膦/六氯乙烷缩合法具有合成成本低、可行性好、稳定性高、合成周期短等突出优点,为推动Ala-Gln类药物大规模的生产和应用提供了可能。国家自然科学基金资助项目(No.21778042);;福建省自然科学基金资助项目(No.2016J05200

(1R,4R)-1-(hydroxydiphenylmethyl)-7,7-dimethylbicyclo [2.2.1] heptan-2-one

The title compound, C22H24O2, has been obtained by a Grignard reaction of (1S, 4R)-methyl 7,7-dimethyl-2-oxo-bicyclo[2.2.1]heptane-1-carboxylate with phenylmagnesium bromide. Intramolecular hydrogen bonding is observed between the carbonyl group and the hydroxy group

A Novel and General Method for the Formation of S-Aryl, Se-Aryl, and Te-Aryl Phosphorochalcogenoates

A new and general method for the synthesis of S-, Se-, and Te-aryl phosphorochalcogenoates (chalcogenophosphates) has been developed. S-P, Se-P, and Te-P bonds were formed by the coupling of readily available dialkyl phosphites with diaryl dichalcogenides at 30 degrees C in dimethyl sulfoxide in the presence of catalytic amounts of copper iodide and diethylamine. The reaction proceeded smoothly without exclusion of moisture or air.Major Program of National Natural Science Foundation of China [20732004, J0630429]; Projects of International Cooperation of the Ministry of Science and Technology of the Peoples Republic of China [2006DFA43030

(1S,4R)-N-[(S)-2-Hydroxy-1-phenylethyl]-7,7-di-methyl-2-oxobicyclo [2.2.1] heptane-1-carboxamide

The title compound, C18H23NO3, has been obtained by the reaction of (1S, 4R)-7,7-dimethyl-2-oxobicyclo[2.2.1] heptane-1-carbonyl chloride with (S)-2-amino-3-phenylpropan-1-ol. The carbonyl functionality of the carboxamide group and the hydroxy group are involved in O-H (. . .) O intermolecular hydrogen bonds

Generalized projective representations for sl(n+1)

It is well known that n-dimensional projective group gives rise to a non-homogeneous representation of the Lie algebra sl(n + 1) on the polynomial functions of the projective space. Using Shen's mixed product for Witt algebras (also known as Larsson functor), we generalize the above representation of sl(n + 1) to a non-homogeneous representation on the tensor space of any finite-dimensional irreducible gl(n)-module with the polynomial space. Moreover, the structure of such a representation is completely determined by employing projection operator techniques and well-known Kostant's characteristic identities for certain matrices with entries in the universal enveloping algebra. In particular, we obtain a new one parameter family of infinite-dimensional irreducible sl(n + 1)-modules. which are in general not highest-weight type, for any given finite-dimensional irreducible sl(n)-module. The results could also be used to study the quantum field theory with the projective group as the symmetry. (C) 2010 Elsevier Inc. All rights reserved

推荐一个化学生物学教学实验——电喷雾质谱研究磷酰基对丙氨酸与溶菌酶分子间相互作用的影响

介绍一个利用电喷雾质谱研究生物大分子与化学小分子相互作用的实验方法。讨论了该实验在化学生物学专业本科生教学工作中的实践效果

Novel regio- and stereoselective phosphonyl radical addition to glycals promoted by Mn(II)-air: syntheses of 1,2-dideoxy 2-C-diphenylphosphinylglycopyranosides

National Natural Science Foundation of China [21272219, 20972142]; State Key Laboratory of Bio-organic and Natural Products Chemistry, CAS [08417]1,2-Dideoxy-2-C-diphenylphosphinylglycopyranosides were first synthesized by the novel Mn(II)-air promoted reaction of diphenylphosphine oxide with various glycals in high yields with excellent regio- and stereoselectivities, which was clarified as a radical addition reaction controlled by the oxygen of vinyl ether