467 research outputs found
Studying the Function of Tespa1 in T Cell by Bone Marrow Reconstitution Model and Listeria Infection Model
T细胞是机体后天免疫系统的重要成员,在抗感染免疫、抗肿瘤免疫和自身免疫病中均发挥重要作用。T细胞在胸腺中完成发育后进入外周免疫器官发挥作用,这背后涉及到一系列复杂的调控机制。厘清T细胞在发育过程中和在外周免疫器官发挥免疫反应中的分子机制,有助于我们为临床抗感染和肿瘤免疫治疗中提供新的免疫干预靶点。近年来陆续发现一些新的分子在胸腺T细胞发育中发挥重要作用,其中Tespa1是最近新报道的一个对T细胞发育具有重要作用的基因。Tespa1分子的缺失会导致T细胞在发育过程中无法进行阳性选择,从而影响T细胞的发育,但是Tespa1分子中影响T细胞发育的关键结构域仍不清楚。我们利用骨髓重构模型验证了Tesp...T cells are an important member of the acquired immune system, T cells play an important role in anti-infection immunity, antitumor immunity and in autoimmune diseases. After completion of T cells in the thymus to complete its development, T cells function in peripheral immune organs, behind this involves a series of complicated regulatory mechanism. Clarifying the molecular mechanism of T cells i...学位:理学硕士院系专业:生命科学学院_生物化学与分子生物学学号:2162014115252
A Study on National Defense Education in University on the Background of Information War
高校国防教育作为我国国防教育不可或缺的一部分,在强化国民国防观念,增强国民国防意识方面发挥着重要的作用。如今,在经济全球化、信息网络化、文化多元化的时代背景下,更加要求我们应该提高高校国防教育教学质量,从而加强高校学生人文知识的学习和人文精神的培养,增强国防教育的吸引力。 本文在对信息化战争背景进行阐释分析的基础上,围绕高校国防教育的特色,深化以内容为主的教学改革,提出如何优化信息化战争背景下高校国防教育的途径和方法:一是确立国家信息安全意识,将防范网络环境下的信息侵略纳入高校国防教育体系;二是建立更趋完善的国防教育体制,优化高校国防教育体系;三是转变教学手段、重新整合教学方法以升华高校国防...National Defense Education in university , an integral part of the National Defense Education in our country, plays an important role in strengthening national defense concept and strengthening the consciousness of national defense . nowadays with the economic globalization, the information network and cultural diversity coming, it demands us to improve the teaching quality of National Defense Edu...学位:教育硕士院系专业:教育研究院_高等教育学学号:X200820900
Method of error compensation for precise grinding the helical rotor tooth profile
针对成形法精密磨削加工螺杆转子螺旋面的问题,研究了螺杆转子加工过程中由工艺系统误差产生的齿廓加工误差的补偿方法。提出了一种基于首件转子磨削后的齿; 廓测量误差,进行预处理再修整砂轮的新算法。使用处理后的补偿数据对砂轮修整后,加工误差明显减小与收敛,大大提高了磨削转子的齿廓制造精度。Aiming at the process of the machining screw rotor helical surface by; forming precision grinding, the compensation method of tooth profile; error caused by the process system error in the process of screw rotor; machining is researched. A new pretreatment and refinish grinding wheel; algorithm is proposed which based on the measurement error of the tooth; profile after the first rotor grinding. After the grinding wheel was; dressed base on the compensated data, machining error is obviously; reduced and convergence, the machining precision of root is improved; obviously.陕西省地方重大资助项
Alkenylcarbyne Complexes Derived from the Reactions of OsXCl-(PPh3)(3) (X=H, Cl) with Propargyl Chloride and Phosphine Ligand-Controlled Transformation of Hydride-Carbyne to Carbene
简单的锇起始物OsHCl(PPh_3)_3(1)或OsCl_2(PPh_3)_3(2)与3-氯-3-甲基-1-丁炔反应可分别得到锇的烯基卡拜配合; 物OsHCl_2(=CCH=CMe_2)(PPh_3)_2(3)和OsCl_3(=CCH=CMe_2)(PPh_3)_2(4).化合物3与二苯基; (苯乙炔基)膦反应可转化为三个二苯基(苯乙炔基)膦配位的锇烯基卡宾配合物OsCl_2(=CHCH=CMe_2)(Ph_2PC=CPh)_3(5); ,而化合物4与二苯基(苯乙炔基)膦反应得到膦配体取代产物OsCl_3(=CCH=CMe_2)(Ph_2PC=CPh)_2(6).二苯基(苯乙炔基; )膦配体较弱的供电子能力及较小的空间位阻是促成化合物3发生锇上的原子氢配体到卡拜碳的1,2-迁移而转化为卡宾配合物5的原因.Reactions of the simple osmium precursors OsHCl(PPh3)(3) (1) or OsCl2(PPh3)(3) (2) with 3-chloro-3-methylbut-1-yne afforded OsHCl2( CCH=CMe2)(PPh3)(2) (3) or OsCl3( CCH=CMe2)(PPh3)(2) (4), respectively. Treatment of 3 with Ph2PC CPh led to alp formation of the tris-diphenyl(phenylethynyl)phosphine alkenylcarbene complex OsCl2(=CHCH=CMe2)(Ph2PC CPh)(3) (5), while complex 4 underwent simple phosphine ligand substitution with Ph2PC CPh to give OsCl3( CCH=CMe2)(Ph2PC-CPh)(2) (6). Presumably, upon the phosphine ligand substitution of PPh3 in 3 by Ph2PC CPh, the relatively electron -poor nature of the later decreased the electron density of the osmium center, and thus promoted the transformation of the hydride-carbyne to carbene via the 1,2 -shift of the hydride ligand from Os to the carbyne carbon, which was then further facilitated by the coordination of a third less bulky Ph2PC-CPh ligand to the osmium center to give the stable 18e product 5.National Basic Research Prpgram of China (973 Program) [2012CB821600];; National Natural Science Foundation of China [21072161
OsXCl(PPh)(X=H,Cl)与炔丙基氯反应合成烯基卡拜配合物及膦配体调控的锇-氢卡拜向卡宾配合物的转化
简单的锇起始物OsHCl(PPh)(1)或OsCl(PPh)(2)与3-氯-3-甲基-1-丁炔反应可分别得到锇的烯基卡拜配合物OsHCl(≡CCH=CMe)(PPh)(3)和OsCl(≡CCH=CMe)(PPh)(4).化合物3与二苯基(苯乙炔基)膦反应可转化为三个二苯基(苯乙炔基)膦配位的锇烯基卡宾配合物OsCl(=CHCH=CMe)(PhPC≡CPh)(5),而化合物4与二苯基(苯乙炔基)膦反应得到膦配体取代产物OsCl(≡CCH=CMe)(PhPC≡CPh)(6).二苯基(苯乙炔基)膦配体较弱的供电子能力及较小的空间位阻是促成化合物3发生锇上的原子氢配体到卡拜碳的1,2-迁移而转化为卡宾配合物5的原因.国家重点基础研究发展计划(973计划,No.2012CB821600);国家自然科学基金(No.21072161)资助项目~~
Analysis on Accounting Information Disclosure of Commercial Banks in China
商业银行是经营货币信用的特殊行业,信用中介的身份使其经营风险高于一般企业。有效的会计信息披露能使银行外部利益相关者了解商业银行所面临的风险及其风险管理能力,从而做出相应的经济决策,以达到规避风险,最大化获利的目的。有效的会计信息披露也能督促商业银行完善自身经营缺陷,从而提高其抵御风险的能力。我国商业银行会计信息披露规范的建设起步较晚,然而伴随着国外商业银行进入中国市场步伐的临近和我国商业银行进入资本市场渴望的加深,完善商业银行会计信息披露规范的需求也日益强烈。本文拟对我国现有商业银行会计信息披露规范的状况及实际执行情况进行分析,并结合境外金融发达国家或地区和国际性组织的成熟规范,对我国商业银行...As a special industry operating money credit, the risks of commercial banks are higher than those of other industries. The banking supervisors and market participants need effective accounting information disclosed by commercial banks to assess their risks and their ability to manage them, and then make relevant decisions. At the same time effective accounting information can urge commercial banks...学位:工商管理硕士院系专业:管理学院工商管理教育中心_工商管理硕士(MBA)学号:20021501
The Discuss about the Improvement of Balanced Scorecard in Enterprise Application
当今社会,企业竞争日益激烈,经营管理过程中面临越来越多的挑战。能否合理评价经营者和企业内部各个部门的绩效,建立更加科学、公平和更具前瞻性、指导性的绩效评价方法,将会极大影响企业的健康发展和企业的前途。传统经营绩效评价方法以财务指标为中心,用单一的投资回报率、利润指标、生产率等作为绩效评价依据,无法全面反映企业经营绩效。针对传统经营绩效评价方法存在的局限性,近年来,国内外掀起了运用平衡计分卡的热潮。平衡计分卡是战略管理工具,是指导企业发展,评价企业发展的工具。平衡计分卡以一套平衡的框架,把愿景和战略转变为目标和指标。它的最大优点就是把企业的战略、愿景、目标、绩效指标、行动方案联系起来,从财务、客...In today’s furious competition world, nearly all enterprises face more and more challenge. The ability to build a forward performance measurement system, which can appraise the performance of managers and corporations fairly and scientifically, will influence badly the healthy development and the corporation’s future. Traditional measurements, which can not reflect wholly, were centered on fin...学位:工商管理硕士院系专业:管理学院企业管理系_企业管理(含财务管理、市场营销、人力资源管理)学号:K20020730
美国国际收支演变中的服务贸易作用及启示
二战以来,美国服务业迅猛发展,已成为世界服务贸易的头号强国。观察美国半个多世纪以来的国际收支多次变化,发现其服务贸易的发展与同期国际收支变化呈现出一定的相关性。对美国国际收支的演变过程进行描述,对服务贸易在其中的作用进行深入分析,提出其对我国服务贸易发展的重要启示
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