167 research outputs found
Transplantation of Porcine Hepatocytes Cultured with Polylactic Acid-O-Carboxymethylated Chitosan Nanoparticles Promotes Liver Regeneration in Acute Liver Failure Rats
In this study, free porcine hepatocytes suspension (Group A), porcine hepatocytes embedded in collagen gel (Group B), porcine hepatocytes cultured with PLA-O-CMC nanoparticles and embedded in collagen gel (Group C), and PLA-O-CMC nanoparticles alone (Group D) were transplanted into peritoneal cavity of ALF rats, respectively. The result showed that plasma HGF levels were elevated post-transplantation with a peak at 12 hr. The rats in Group C showed highest plasma HGF levels at 2, 6, 12, 24 and 36 hr post-transplantation and lowest HGF level at 48 hr. Plasma VEGF levels were elevated at 48 hr post-transplantation with a peak at 72 hr. The rats in Group C showed highest plasma HGF levels at 48, 72, and 96 hr post-transplantation. The liver functions in Group C were recovered most rapidly. Compared with Group B, Group C had significant high liver Kiel 67 antigen labeling index (Ki-67 LI) at day 1 post-HTx (P < .05). Ki-67 LI in groups B and C was higher than that in groups A and D at days 5 and 7 post-HTx. In conclusion, intraperitoneal transplantation of porcine hepatocytes cultured with PLA-O-CMC nanoparticles and embedded in collagen gel can promote significantly liver regeneration in ALF rats
CARDIOPROTECTIVE ROLES OF THE CHINESE MEDICINAL FORMULA BAO-XIN-TANG ON ACUTE MYOCARDIAL INFARCTION IN RATS
Background: Bao-Xin-Tang (BXT) is a traditional Chinese medicinal formula used for the treatment of coronary heart disease and
known to have favorable therapeutic benefits. The current study was designed to determine whether BXT has a cardioprotective role
for acute myocardial infarction. The underlying mechanisms were also explored.
Materials and Methods: The Sprague-Dawley rat model of acute myocardial infarction was established by occluding the left anterior
descending branch of the coronary artery. After a 3-h ischemic period, we determined the myocardial infarction size, inflammatory
components, and antioxidant activities.
Results: The data showed that BXT could reduce the infarction size and lower the levels of C-reactive protein, interleukin-6, and
myeloperoxidase, and increase the activities of superoxide dismutase and the anti-inflammatory cytokine, interleukin-10. These results
indicate that administration of BXT, following acute myocardial infarction, could reduce infarct size.
Conclusion: The effects of BXT may be related to its anti-inflammatory and anti-oxidative properties
Immobilizing chromate reductase NfoR on magnetic biochar reduced Cr(VI) in copper-containing wastewater
High speed self-testing quantum random number generation without detection loophole
Quantum mechanics provides means of generating genuine randomness that is
impossible with deterministic classical processes. Remarkably, the
unpredictability of randomness can be certified in a self-testing manner that
is independent of implementation devices. Here, we present an experimental
demonstration of self-testing quantum random number generation based on an
detection-loophole free Bell test with entangled photons. In the randomness
analysis, without the assumption of independent identical distribution, we
consider the worst case scenario that the adversary launches the most powerful
attacks against quantum adversary. After considering statistical fluctuations
and applying an 80 Gb 45.6 Mb Toeplitz matrix hashing, we achieve a
final random bit rate of 114 bits/s, with a failure probability less than
. Such self-testing random number generators mark a critical step
towards realistic applications in cryptography and fundamental physics tests.Comment: 34 pages, 10 figure
Establishment and biological characterization of a dermal mesenchymal stem cells line from bovine
Transcriptome analysis of Sporisorium scitamineum reveals critical environmental signals for fungal sexual mating and filamentous growth
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