Multifunctional Core-Shell Upconverting Nanoparticles for Imaging and Photodynamic Therapy of Liver Cancer Cells

通讯作者地址: Chen, XL (通讯作者),Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China 地址: 1. Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China 2. Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China 3. Xiamen Univ, Dept Elect Sci, Fujian Key Lab Plasma & Magnet Resonance, Xiamen 361005, Peoples R China 4. Xiamen Univ, Dept Commun Engn, Fujian Key Lab Plasma & Magnet Resonance, Xiamen 361005, Peoples R China 电子邮件地址: [email protected]; [email protected] upconversion nanoparticles (UCNPs) have attracted considerable attention for their application in biomedicine. Here, silica-coated NaGdF4:Yb,Er/NaGdF4 nanoparticles with a tetrasubstituted carboxy aluminum phthalocyanine (AlC4Pc) photosensitizer covalently incorporated inside the silica shells were prepared and applied in the photodynamic therapy (PDT) and magnetic resonance imaging (MRI) of cancer cells. These UCNP@SiO2(AlC4Pc) nanoparticles were uniform in size, stable against photosensitizer leaching, and highly efficient in photogenerating cytotoxic singlet oxygen under near-infrared (NIR) light. In vitro studies indicated that these nanoparticles could effectively kill cancer cells upon NIR irradiation. Moreover, the nanoparticles also demonstrated good MR contrast, both in aqueous solution and inside cells. This is the first time that NaGdF4:Yb,Er/NaGdF4 upconversion-nanocrystal-based multifunctional nanomaterials have been synthesized and applied in PDT. Our results show that these multifunctional nanoparticles are very promising for applications in versatile imaging diagnosis and as a therapy tool in biomedical engineering.NSFC 21101131 21021061 20925103 20871100 Fok Ying Tung Education Foundation 121011 NSF of Fujian Province 2009J06005 Fundamental Research Funds for the Central Universities 2010121015 Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry NFFTBS J103041

抽水蓄能电站进水阀枢轴密封更换工艺简述

抽水蓄能机组作为现阶段成熟的储能手段，对消纳吸收新能源，保障电网稳定具有重要意义。论文对抽水蓄能电站进水阀枢轴密封更换的工艺进行简述，便于各电站借鉴采纳，提高工作效率和安全性。</jats:p

Optimal Preparation of Dithioamino Starch Xanthogenate and Its Characterization

以可溶淀粉和原乙酸三甲酯进行缩醛反应生成淀粉环酯,在氨水中交联、接枝共聚、磺化合成出以氮为中心的交联接枝共聚淀粉黄原酸盐(dithioamino starch xanthogenate,DSX)。通过正交试验设计方法优化制备条件,结果表明:原料淀粉10g、交联剂(环氧氯丙烷)1.77g、引发剂(过硫酸铵)0.053g、接枝单体(丙烯酰胺)3.37g和二硫化碳6.30g,合成的产物(DSX)对模拟废水中Cu2+的去除率达到98.5%。采用红外图谱、元素分析、核磁、热分析、扫描电镜等多种手段对产物进行表征。In order to synthesize a novel dithioamino starch xanthogenate（DSX）,the acetalization reaction between soluble starch and trimethyl orthoacetate was carried out to form starch acetal-3,6 ring ester,followed by cross-linking in aqueous ammonia,graft copolymerization with acrylamide and sulfonation.Using orthogonal array design,the optimal reaction system was determined to consist of： 10 g of starch,1.77 g of cross-linking reagent,0.053 g of initiator,3.37 g of graft monomer and 6.30 g of carbon disulfide.The synthesized product could remove 98.5% Cu2＋ from simulated wastewater.Further,its structure was characterized by FT-IR,elemental analysis,nuclear magnetic resonance（13C-NMR and H-NMR）,thermogravimetric analysis（TG） and scanning electron microscope（SEM）.国家自然科学基金项目(41061044);广西自然科学基金重点项目(2010GXNSFD013016);广西教育厅“广西高校优秀人才资助计划”项目(桂教人[2007]70号