荒漠肉苁蓉苯乙醇苷对酒精诱导的慢性肝损伤的修复作用（英文）

为了研究荒漠肉苁蓉对酒精诱导的慢性肝损伤的修复效果及其作用机制,从荒漠肉苁蓉中提取并纯化苯乙醇苷。抗氧化活性研究结果表明,苯乙醇苷具有显著的抗氧化活性。另外,分别通过体外和体内实验研究了苯乙醇苷的肝保护活性。在体外实验中,苯乙醇苷可显著提高Hep G2细胞的存活率。对酒精诱导的肝损伤小鼠模型进行动物体内实验,结果表明苯乙醇苷可显著恢复由酒精诱导的血清指标(丙氨酸氨基转氨酶、天冬氨酸转氨酶、&gamma;-谷氨酰转肽酶、酸性磷酸酶、甘油三酯和低密度脂蛋白胆固醇)和肝脏生化指标(超氧化物歧化酶、谷胱甘肽S-转移酶、谷胱甘肽、谷胱甘肽过氧化物酶、丙二醛和甘油三酯)水平。模型动物的肝组织显微结构中,突出的病理学脂肪微泡和细胞坏死情况也由于灌胃苯乙醇苷而显著减弱。这些结果表明,针对酒精诱导的慢性肝损伤,苯乙醇苷具有显著的肝保护活性。所述机制涉及对相应酶(包括超氧化物歧化酶、谷胱甘肽S-转移酶、谷胱甘肽过氧化物酶)活性以及对脂质过氧化物(丙二醛)的调节。</p

Total morphosynthesis of biomimetic prismatic-type CaCO3 thin films

我校材料学院姜源副教授，与浙江大学唐睿康教授课题组、德国Konstanz大学Helmut Cölfen教授课题组合作，首次利用全合成手段获得了仿贝类棱柱层结构的碳酸钙薄膜，并实现了仿生薄膜微结构的精准调控，由此获得了优异的力学性能。本研究团队基于生物矿物的空间结构异质性，并参考了传统晶态薄膜材料合成中的液相外延方法，首次设计出了多步仿生矿化路线，在常温液相条件下成功地构筑了利用聚电解质稳定的矿物种子层，并在此基础上利用外延矿化方法构筑了碳酸钙的棱柱层结构。本研究制备的棱柱层薄膜不但与相对应的生物矿物在微结构上具有高度的相似性，同时还具有类似的硬度和杨氏模量。文中提出的基于种子层外延生长的多步矿化路线是获得棱柱层仿生结构的普适方法，也加深了人们对于生物矿化机制的认识。【Abstract】Biomimetic mineralization can lead to advanced crystalline composites with common chemicals under ambient conditions. An exceptional example is biomimetic nacre with its superior fracture toughness. The synthesis of the prismatic layer with stiffness and wear resistance nonetheless remains an elusive goal. Herein, we apply a biomimetic mineralization method to grow prismatic-type CaCO3 thin films, mimicking their biogenic counterparts found in mollusk shells with a three-step pathway: coating a polymer substrate, deposition of a granular transition layer, and mineralization of a prismatic overlayer. The synthetic prismatic overlayers exhibit structural similarity and comparable hardness and Young’s modulus to their biogenic counterparts. Furthermore, employment of a biomacromolecular soluble additive, silk fibroin, in fabrication of the prismatic thin films leads to micro-/nano-textures with enhanced toughness and emerging under-water superoleophobicity. This study highlights the crucial role of the granular transition layer in promoting competition growth of the prismatic layer.Y.J. acknowledges financial support from the National Natural Science Foundation of China (NSFC; 21303144) and Science Foundation of the Fujian Province, China (2014J01207). R.T. acknowledges financial support from NSFC (21625105). X.Y.L. thanks NSFC (U1405226), the “111” Project (B16029), Fujian Provincial Bureau of Science & Technology (2014H6022), and the 1000 Talents Program from Xiamen University