柯尔施政治思想的发展

通过重读柯尔施的著作及信件,追溯了其政治思想的发展历程。作为一个马克思主义者,柯尔施一直在批判和反思马克思主义,并从无产阶级行动的角度找到理论与实践的关联。他坚持在工人自治运动中寻求民主解放的可能,并用革命与反革命、政治与经济的对立来表达政治矛盾。他提出了一系列理论假设,并尝试背离经典马克思主义的理论阐释方法去重塑他理想中的"马克思主义"

Experimental study on effect of Changrun Formula in regulating expression of AQP3 and AQP9 in colon mucosa of functional constipation rats

目的:观察肠润方对功能性便秘模型大鼠结肠黏膜AQP3、AQP9表达的影响,探究其调控AQP3、AQP9表达的分子机制。方法:60只SD大鼠随机分为空白组、模型组、阳性对照组(麻仁丸组)、肠润方组、肠润方联合P38MAPK抑制剂SB203580组。用复方地芬诺酯制造大鼠便秘模型,采用免疫组织化学及实时荧光定量PCR(q RT-PCR)检测大鼠便秘模型近端及远端结肠黏膜AQP3、AQP9的表达;Western Blot检测信号传导通路相关分子P38MAPK及P-P38MAPK的表达。结果:造模成功后,模型组近端结肠黏膜AQP3表达较空白组明显上升,而远端结肠黏膜AQP9表达较空白组明显下降(t值分别为3.148和7.069,P值均0.05)。肠润方联合P38MAPK抑制剂SB203580治疗后,近端结肠黏膜AQP3 m RNA水平显著上升(t=5.922,P0.05). The level of AQP3 m RNA in proximal colonic mucosa was significantly increased(t=5.922, P<0.01), and AQP9 m RNA was significantly decreased in distal colonic mucosa(t=4.038, P<0.01); The relative expression of P-P38/P38 protein was significantly decreased(t=19.419, P<0.01). Conclusion: The therapeutic action ofChangrun Formula on functional constipation rat models might through inhibiting the expression of AQP3 in proximal colon, and accelerating on expression of AQP9 in distal colon, and the regulating mechanism might relate with the inhibition on P38 MAPK and AKT phosphorylation.福建省自然科学基金项目(No.2012D043)~

基底力学微环境调控胚胎干细胞肝向分化的规律及分子机制

目的通过建立硬度耦合拓扑结构基底影响胚胎干细胞(embryonic stem cell, ESCs)肝向分化的实验体系,深化力学微环境对ESCs肝向分化的生物学过程及力学-生物学耦合规律及分子机制的认识,为阐明力致ESCs肝向分化的生理及体外调控过程提供基础数据,并为肝脏疾病治疗和工程化肝组织构建研究提供新思路、新视角。方法 将聚丙烯酰胺水凝胶按特定配比制备不同硬度、拓扑结构及两者耦合的基底力学微环境,建立不同硬度耦

宽带可调谐掺镱双包层光纤激光器

采用高功率975 nm多模半导体激光器(LD)作为抽运源,以大模场掺Yb3+双包层光纤(YDCF)作为激光增益介质,运用能够承受较高功率运行的利特罗(Littrow)光栅外腔调谐结构,实现了宽带可调谐激光输出。实验中,双包层光纤采用最优光纤长度14 m,光栅经仔细调整后有效入纤反馈效率约20%,当入纤抽运功率约1.3 W时,激光器达到阈值并开始振荡。通过连续旋转光栅,激光输出波长能在1046~1121 nm之间实现可调谐,可调范围达75 nm。当入纤抽运功率为48 W时,在1089 nm波长处获得最大输出功率23.7 W,相应斜率效率为53%。最后,基于数值模拟简单地分析了激光输出特性,实验结果与数值模拟结果基本保持一致

基底力学微环境对干细胞生物学功能的影响

目的:干细胞是一类没有分化的多潜能细胞,具有无限自我增殖和分化成多种细胞的能力。干细胞生长的生理微环境称为壁龛(niche),基底硬度、拓扑结构和三维尺寸等物理力学特征决定干细胞的命运。尽管越来越多的证据证明基底力学微环境对干细胞干性及分化具有重要影响,但基底硬度、拓扑结构和三维尺寸单因素及多因素耦合如何影响干细胞的特性及其分子机制还不够清楚。方法:为模拟体内干细胞生长力学微环境,考察不同基

Selectivity of biopolymer membranes using HepG2 cells

Bioartificial liver (BAL) system has emerged as an alternative treatment to bridge acute liver failure to either liver transplantation or liver regeneration. One of the main reasons that the efficacy of the current BAL systems was not convincing in clinical trials is attributed to the lack of friendly interface between the membrane and the hepatocytes in liver bioreactor, the core unit of BAL system. Here, we systematically compared the biological responses of hepatosarcoma HepG2 cells seeded on eight, commercially available biocompatible membranes made of acetyl cellulose&ndash;nitrocellulose mixed cellulose (CA&ndash;NC), acetyl cellulose (CA), nylon (JN), polypropylene (PP), nitrocellulose (NC), polyvinylidene fluoride (PVDF), polycarbonate (PC) and polytetrafluoroethylene (PTFE). Physicochemical analysis and mechanical tests indicated that CA, JN and PP membranes yield high adhesivity and reasonable compressive and/or tensile features with friendly surface topography for cell seeding. Cells prefer to adhere on CA, JN, PP or PTFE membranes with high proliferation rate in spheriod-like shape. Actin, albumin and cytokeratin 18 expressions are favorable for cells on CA or PP membrane, whereas protein filtration is consistent among all the eight membranes. These results further the understandings of cell growth, morphology and spreading, as well as protein filtration on distinct membranes in designing a liver bioreactor.</p

Neural Mechanism of Subjective Well-being

主观幸福感是社会认知领域一直关注的重要问题.Kalmeman等人提出的评价系统模型为主观幸福感的研究提供了基本框架.主观幸福感形成过程中,评价系统的主要产物包括即时效用、回忆效用、抉择效用和预期效用,这些效用都有着各自特殊的神经机制.主观幸福感的影响因素分为内部和外部因素,它们也对应着各异的神经基础.未来主观幸福感领域的研究应遵循生理机制和心理机制相结合的整合研究思路

Economic Consequences of Corporate Financial Restatement: An Empirical Analysis of Managerial Reputation

在我国当前诚信水平整体偏低的情况下,声誉机制是否增进了公司 治理的效率? 理论界还少有研究.本文选择上市公司财务重述行为这一视角,以２００７~２００９年发布涉及核心会计利润和盈余调整财务重述公告的１８４家A股上市公司为研究样本,实证检验财务重述行为对管理层声誉的影响,以此检验声誉机制在公司治理中的作用.结果显示,财务重述公告降低了上市公司管理层的声誉;另外,财务重述也显著降低了管理层的媒体覆盖度,进而降低了管理层的声誉.本文选定财务重述事件中的声誉治理作用这一新的研究视角,丰富了我国公司治理的研究,并为监管部门和投资者的决策提供重要参考.There is little evidence on whether managerial reputation facilitates more efficient corporate governance in institutional environment that is considered having low credibility and low integrity as in China. Using management turnover as a proxy for managerial reputation, we examine the effect of financial restatements on managerial reputation. We find that financial restatements have a negative effect on managerial reputation and taint the public image of the management. We extend the prior research on the economic consequences of financial restatements and provide evidence that can be used by regulation authorities for making policies and by investors for making investment decisions.作者单位：大连理工大学管理与经济学部/东北财经大学会计学院/中国内部控制研究中

A Psychological Perspective on the Study of Modesty

谦虚既是一种人格,也是一种社会行为。目前对谦虚的测量主要采用外显量表和内隐测试。谦虚在心理健康、人际关系和组织管理等方面都可以起到积极的作用。谦虚受到社会文化、情境等外部因素以及性别、信念等个体因素的影响。儿童谦虚观念的形成受到行为本身真实性和儿童对环境的认知这两方面的影响。该文从含义、测量、功能、影响因素、发展等方面对心理学界的谦虚相关文献进行了梳理,结果发现,相比国际心理学界日益增多的实证研究,本土对谦虚的探讨大多停留在理论层面而且缺乏理论建构。期望该文能唤起国内研究者对谦虚研究的重视,让传统价值在当代中国发挥新的作用。&nbsp;</p