Development of multicyclic peptide templates and peptide probes through stable thioether-bond

蛋白质通过各类蛋白酶的催化反应或蛋白质–蛋白质间相互作用参与了细胞内大多数的机制运作过程。因此，研究和调控生物体异常蛋白酶表达及内大多数的机制运作过程。因此，研究和调控生物体异常蛋白酶表达及研究和调控生物体内异常的蛋白酶表达及蛋白质相互作用对理解生命体系、发展新型药物疗法有着重要意义。多肽类调控剂有着易合成修饰、免疫原性低、与靶蛋白结合特异性高等优点，环肽分子（特别是多元环肽）又进一步通过构象限制提高了多肽的稳定性、刚性及结合亲合力，因此是一类很有潜力的蛋白酶或蛋白质相互作用调控剂。在自然界中，常通过二硫键对蛋白或活性肽构象进行环化限制，这些富二硫键天然生物分子也为多肽环化提供了丰富的模板，但...Proteins participate in most of biological and pathological processes in cells via catalyzing different kinds of reactions or via thousands of protein- protein interactions. Consequently, investigate and control over inappropriate proteases expression and protein-protein interactions are important for better understanding of biology systems and can potentially be the effective strategy for therap...学位：理学硕士院系专业：化学化工学院_分析化学学号：2052014115152

推動非正規教育課程認證制度面面觀

[[issue]]126

台北市立社會教育館經營策略分享

[[issue]]129

Peter Jarvis經驗學習之探討

[[issue]]128

企業選擇會計師或代客記帳業者代為辦理會計及稅務事務之考慮因素

各種版本之報稅代理人法草案均以「協助中小企業之報稅」，惟本研究中發現，其中一家受訪者資本額一億，營業額六億，公司員工已達50人，是否仍屬於得以將帳務委外處理的「中小企業」則有待斟酌。且公司的帳務攸關公司決策，企業的發展，乃至影響臺灣的經濟。故於立法時，有必要明文規定符合某一標準始得委任帳務代理人，且法令應導引企業漸漸朝自已記帳為目標。大多數企業是以節省人事費用為考量而委外記帳，委託的服務除了帳務處理外，均是工商登記及變更登記。也就是其專業服務範圍需求甚小。選任代客記帳業者較重視認識的人的推薦，也較在乎公費的高低，同時也認為代客記帳業者較會計師收費便宜。而選任會計師者則較重視專業程度。故實證結論為選擇代理人以公費為考慮因素的企業較會選擇代客記帳業者。無論選任會計師或代客記帳業者均認為關係很重要，能力也很重要。但選擇代客記帳業者較選擇會計師者重視關係，同時也認為代客記帳業者的關係較會計師好而較會選擇代客記帳業者。而選任代理人以能力為選擇因素者，較會選任會計師。選擇代客記帳業者較偏向以擴大書面審核方式申報營所稅。受訪者中簽證需求低，但若為代客記帳業者記帳，一旦需要簽證，其簽證會計師極有可能由其代客記帳業者選任。大多數委外記帳之企業均記載內帳，且內帳用途較外帳用途多，外帳只作為報稅及貸款，內帳則可做管理用。在整個訪談過程中，委託代理人辦理會計事務之企業對於會計師及代客記帳業者的區分觀念不清楚。也均表示其對稅法觀念極為模糊，部分企業表示希望政府在租稅教育上可以提供實質的幫助，例如免費諮詢、稅務政令的宣導。而在會計師與代客記帳業者的分別，多數表示不清楚，期待政府幫助他們如何用簡易方法辨識、宣導這兩者的業務範圍有何不同、收費標準是什麼，是否如一般人認為代客記帳業者的收費較會計師收費低，也就是企業期待政府可以協助其在這兩者之間作一正確選擇

社教機構與學習型組織

[[issue]]125

[[alternative]]專訪毛毛蟲兒童哲學基金會董事盧本文

[[issue]]130

A Study of the Developmental Components in the Life-course of Middle-aged Adults, and their Relevant Influence Factors

[[abstract]]ABSTRACT A Study of the Developmental Components in the Life-course of Middle-aged Adults, and their Relevant Influence Factors Adviser: Professor Lin Mei-Ho Researcher: Wang Ching-Hui The main purpose of this study is to examine key developmental components in the life-course of middle-aged adults in Taiwan, and specifically exploring factors that potentially impact and/or predict events in these developmental components during the mid-life period. Based on a review of the relevant literatures concerning mid-life development, this study was conducted by means of a questionnaire, designed by the researcher, entitled "Developmental Issues in the Life-course of Middle-aged Adults." The subjects of the survey possess the following characteristics: 40 to 60 years of age, married with one or more children. The sample size is 296. The statistical principles of data analysis are frequency, percentage, mean, independent sample t-test, one-way ANOVA, and multiple regression. The main findings of the study are as follows: 1. According to a self-evaluation, the subjects are in a good health. 2. Four salient developmental components of middle-aged adults can be identified: health and leisure activities, marital and family life, interpersonal and social relationships, and work and career achievement. 3. The most important factor in explaining differences in life-course development is the subject's health status. Based on the findings of the study, the following conclusions have been drawn: 1. Four key dimensions of life-course development identified above are truly important. 2. The core developmental component for middle-aged adults is marital and family life. 3. Factors that impact the four components for middle-aged adults include gender, age, educational background, type of occupation and health status. 4. Health status is the most important factor in predicting the developmental condition for middle-aged adults, and vice versa. Based on the above conclusions, this study has proposed several recommendations: 1. Suggestions for middle-aged adults (1) Focusing on the management of the four key developmental components. (2) Balancing family life and professional achievement. (3) Maintaining a sound state of health, in order to cultivate the energy needed for optimal development. (4) Participating in learning activities which fulfill developmental needs. 2. Suggestions for adult educators (1) Designing learning activities according to the above developmental components. (2) Providing the varied programs and teaching styles based on middle-aged adults’ characteristics. 3. Suggestions for further research (1) Expanding the scope of subjects to include middle-aged adults with a wider variety of marital statuses, as well as a different number of children. (2) Employing methods other than a survey, such as interviews or meta-analysis. (3) Adding other variables, such as marital status, geographical location of subjects, family income, number of children, learning conditions, and the timing of specific life events. (4) Furthering studies such as mental and spiritual development, personality and emotional management, civic involvement, social responsibility, and career transition could be under consideration.

台灣優衣庫(UNIQLO疫情前後經營策略之研究)

[[abstract]]1990年崛起的UNIQLO正值日本經濟「失落的十年」，18年後遇上全球金融海嘯，在這種情況下UNIQLO的營業額卻是以倍數成長，漸漸地爬上日本服飾業的龍頭，許多公司面臨營運問題，而UNIQLO的營業額卻還在持續創新高。在這一次新冠肺炎疫情的風波下UNIQLO營業額是否也會逆成長UNIQLO未來又會面臨什麼樣的情況呢? 我們首先會介紹新冠肺炎，並了解疫情所帶來的影響，研究UNIQLO的經營策略與行銷策略，利用文獻分析法找到我們需要的資料，最後闡述UNIQLO未來的發展，關於網路商店的建議