Total Synthesis of (±)-polycitorol A

摘要 Polycitorols类生物碱是2005年由Tanaka小组从一种叫Polycitoridae的海洋 海鞘类生物体中分离得到。Polycitorols独特的化学结构及潜在的生物活性引起了 许多研究小组的浓厚兴趣。本论文围绕(±)-polycitorolA的全合成开展研究。 本论文的主要目标是：将实验室最新发展的一氯二茂钛催化的仲酰胺、醛与 活泼烯烃的三组分串联自由基偶联反应方法，应用于天然产物生物碱 (±)-polycitorolA的全合成中构筑氮杂季碳中心；应用氨基甲酸酯的阳极氧化反应， 简便构筑C-2正丁基侧链。论文取得结果如下： 从2-氧代环己烷丙腈2出发，经过9...Abstract The polycitorols alkaloid was isolated by Tanaka and co-workers from a marine ascidian of the family Polycitoridae in 2005. Due to its promising biological activity and challenging structure, this molecule has attracted the attention of many research groups. Focused on the total synthesis of (±)-polycitorol A, this thesis contains two parts: (1) Utilizing the titanocene monoc...学位：理学硕士院系专业：化学化工学院_有机化学学号：2052014115155

Discussion on the Correlation Between Development of Liver Cancer and Phlegm Based on Recognition to Phlegm in Danxi's Mastery of Medicine

肝癌的治疗目前对人类来说仍是一个难以攻克的难题。基于《丹溪心法·痰》对中医病理产物“痰“的认识与阐述,探讨肝癌与痰的病因病机相关性。通过阐述痰的本质、肝癌的病因病机与痰的关系论证肝癌与痰的相关性。并结合文献,对我国三个肝癌高发区致病危险因素的中医辨证进行分析,进一步阐明痰在肝癌发病中的重要促进作用,以期对肝癌的临床治疗发挥指导作用,重视肝癌从痰论治。The therapy of liver cancer is still a tough problem to mankind to hard to overcome now.The article discussed the correlation between development of liver cancer and the pathological product phlegm of traditional Chinese medicine from the angle of etiological factor and pathogenesis,which based on recognition to phlegm in Danxi's Mastery of Medicine (Danxi Xinfa).It further clarified the important promotive effect of phlegm in the development of liver cancer through expounding the essence of phlegm,arguing the correlation between liver cancer's etiological factor and pathogenesis and phlegm,combining literatures to analyze the risk factors of liver cancer in three high pathogenic districts in China that based on syndrome differentiation of traditional Chinese medicine.We wish it can provide some guidance to the clinical treatment of liver cancer and help to think highly of treating liver cancer from the pathological product phlegm.厦门大学新聘教师科研启动项目(ZK1014

主要资源国家政治生态情况及其对铝土矿政策的影响

Vesuvius, dominating the densely-populated Neapolitan area, is one of the most dangerous volcanoes in the World. Its destructive power derives from energetic subplinian and plinian eruptions, such as the one which occurred in 79 A.D. Generally such large-scale events follow a long period of quiescence; a behaviour interpreted as the gradual build-up of magma volumes between periods of major activity. After the 1631 subplinian eruption until the last 1944 A.D. eruption, it experienced an almost continuous and less energetic explosive/effusive activity. The erupted magmas are characterized by undersaturated potassic to ultrapotassic nature, and compositional and Sr-isotopic variability. Furthermore geobarometric studies indicate two different crystallization depths located at 4 and >11 km, respectively. According to most of the recent literature, the eruptions were triggered by the injection in a shallower magma chamber, of isotopically distinct magma batches derived from heterogeneous mantle source(s) and/or contamination processes occurred within the deep reservoir. In our review of petrochemical data, we consider the period between the 3550 years BP plinian eruption and the 472 A.D. sub-plinian eruption, which includes 79 A.D. event, and the most recent period of activity which started in 1631 A.D. and lasted up to the 1944 A.D. eruption, characterized by a near continuous effusive/explosive activity. For both periods we identify a correlation between Sr-isotopical features of magmas and their crystallization depth. In particular, we show that pyroxenes have Sr-isotopic ratios lower than 0.7074 and an equilibrium crystallization depth of 22-11 km. Moreover feldspars have higher 87Sr/86Sr values (0.7075-7) and an equilibrium crystallization depth of about 4 km. Therefore the most radiogenic magmas did not derive from a deeper reservoir but their higher Sr-isotopic ratios have been acquired at a shallower depth likely by crustal contamination during magma evolution. In contrast, the lower Sr-isotope compositions characterise the less contaminated magmas coming from deeper crustal levels. On the basis of this evidence, the temporal Sr-isotopical variation of magma which erupted in the 1631-1944 A.D. period probably derives from the progressive withdrawal of the shallow magma chamber, which was completely empty before the 1805-1944 A.D. period of volcanism. Therefore the effusive and explosive events of the most recent 1805-1944 A.D. period were fed directly by the deep reservoir located at a depth exceding 11 km

地磷莫斯的免疫抑制效果及机制的研究

目的临床上已应用多种免疫抑制剂,但是因为其价格昂贵,毒副作用强等等原因阻碍了其在临床的应用,雷帕霉素在临床上的应用已得到公认。但是由于雷帕霉素的水溶性小,半衰期长,水溶性较弱,化学稳定性较弱,限制了其在临床的应用。雷帕霉素的的衍生物地磷莫斯具有高溶解性、高稳定性、高生物利用度等优点。地磷莫斯的诸多优点已得到FDA以快速通道方式批准,应用于软组织与骨肉瘤的治疗。关于治疗血液癌(淋巴瘤和白血病)的二期临床试验已经完成,子宫内膜癌的二期临床试验也已展开。为了研究其在免疫抑制方面的作用机制,我们进行一系列体外实验,观察其免疫抑制效果,研究其免疫抑制机制,为地磷莫斯进一步进行体内试验打下基础,为其能顺利扩大临床应用做好铺垫。方法我们首先采用淋巴细胞转化实验来观察地磷莫斯对淋巴细胞与T细胞增殖的抑制作用,确定地磷莫斯的免疫抑制作用及其免疫抑制发挥的浓度,再用凋亡实验、克隆无能实验等探讨地磷莫斯的免疫抑制作用机制。结果我们运用淋巴细胞转化实验确定了地磷莫斯可以抑制淋巴细胞的增殖;我们用流式检测术,发现地磷莫斯不会引起淋巴细胞/T细胞的凋亡;克隆无能实验证明了克隆无能是地磷莫斯诱导免疫耐受的机制之一。结论通过本课题的研究,我们首次证实了地磷莫斯在体外通过抑制淋巴细胞/T细胞增殖,诱导克隆无能等方法发挥免疫抑制作用,为地磷莫斯应用于器官移植领域奠定了基础,促进了地磷莫斯从基础研究向临床器官移植的转化

不同保水固沙措施对沙培番茄生长和基质环境的影响

针对我国荒漠化危害严重,不利于植物种植等系列问题,以番茄为试验材料,结合纸膜、保水剂、生物基固沙剂等不同保水固沙措施,分析各处理下基质的理化性质以及番茄的生物学性状,以探明各处理对沙地环境的改善效果及对番茄生长的影响,为沙漠的防治及沙产业的发展提供参考。结果表明:瓦楞纸处理显著提高了番茄果实的有机酸、可溶性糖含量,分别比CK高27. 78%、8. 87%,其pH值比CK高0. 89,速效氮含量是CK的40倍;牛皮纸处理20~40 cm含水量比CK高73. 40%;保水剂处理可明显促进根系的生长发育,其根长、根直径以及体积分别比CK高16. 25%、29. 17%、56. 58%,番茄可溶性固形物含量比CK高7. 17%,沙子的比重和总孔隙度分别比CK高12. 88%、38. 35%,但容重比CK低6. 88%;生物基B处理可明显提高果实内可溶性糖含量,比CK高15. 53%,可显著提高沙子中的速效钾含量,比CK高55. 99%,有机质含量比CK高10. 91%;生物基A处理对番茄的株高有明显的促进作用,比CK高19. 81%,叶绿素含量比CK高8. 24%,番茄根系的总长比CK高45. 95%,叶片净光合速率是CK的1. 66倍,蒸腾速率以及气孔导度都相对较高,果实内可溶性固形物以及可溶性糖的含量分别比CK高6. 33%、8. 87%,容重比CK高3. 33%,速效氮含量是CK的16倍。通过主成分分析,生物基A的综合得分最高。因此,生物基A处理对促进番茄生长发育以及改善沙地生态环境效果最显著。宁夏回族自治区“十三五”重大研发项目(2016BZ0902);;“十二五”国家科技支撑计划项目(2014BAD05B02);;吴忠国家园区专项(2016BN05);;宁夏回族自治区科技创新领军人才项目(KJT2017001