摘要 Polycitorols类生物碱是2005年由Tanaka小组从一种叫Polycitoridae的海洋 海鞘类生物体中分离得到。Polycitorols独特的化学结构及潜在的生物活性引起了 许多研究小组的浓厚兴趣。本论文围绕(±)-polycitorolA的全合成开展研究。 本论文的主要目标是：将实验室最新发展的一氯二茂钛催化的仲酰胺、醛与 活泼烯烃的三组分串联自由基偶联反应方法，应用于天然产物生物碱 (±)-polycitorolA的全合成中构筑氮杂季碳中心；应用氨基甲酸酯的阳极氧化反应， 简便构筑C-2正丁基侧链。论文取得结果如下： 从2-氧代环己烷丙腈2出发，经过9...Abstract The polycitorols alkaloid was isolated by Tanaka and co-workers from a marine ascidian of the family Polycitoridae in 2005. Due to its promising biological activity and challenging structure, this molecule has attracted the attention of many research groups. Focused on the total synthesis of (±)-polycitorol A, this thesis contains two parts: (1) Utilizing the titanocene monoc...学位：理学硕士院系专业：化学化工学院_有机化学学号：2052014115155
