AHPN衍生物的合成及其与RARγ的结合活性研究

目的本实验以6-{3’-(1-金刚烷基)-4’-羟基苯基}-2-萘甲酸(AHPN)母核为结构基础,设计、合成一系列AHPN衍生物,并对这些衍生物做初步的活性筛选,期望找到活性显著的衍生物。方法以对溴苯酚和1-金刚烷醇为原料经取代、缩合、氧化、还原等反应合成AHPN衍生物,经过1H-NMR、13C-NMR、HR-MS表征,并利用Biacore技术检测衍生物与蛋白质之间的结合能力。结果衍生物7c、6c、6e、6h显示出了显著优于先导化合物AHPN与视黄酸核受体γ(RARγ)的结合能力,亚磷酸二甲酯基与氮杂环的引入提高了该类化合物的活性。结论该类AHPN衍生物与RARγ结合能力显著,有进一步研究的价值。扬州市邗江区科技计划项目资助;;福建省基金项目资助(2014Y0044);;国家海洋局第三海洋研究所基本科研业务费专项资金资助项目(海三科2016044

X射线双星系统的探测

搜寻X射线双星并建立大规模样本是解决众多科学问题(如\"银河系中有多少黑洞X射线双星?黑洞和中子星之间有无质量间隙?球状星团中有无黑洞?\"等)的基础.爱因斯坦探针卫星拥有更灵敏的探测能力,将在运行的几年之中,预计可以发现一批新的中子星和黑洞X射线双星,研究其空间和动力学质量分布成为解决上述问题的关键.国家重点研发计划(编号:2016YFA040080X);;国家自然科学基金(编号:1133305);;中国科学院战略性先导科技专项(编号:XDA15052100,XDB23040000)资助项

Nursing management of a rectal cancer patient with skin mucous membrane separation after Hartmann’s procedure (1例直肠癌患者行Hartmann术后肠造口皮肤黏膜分离的护理)

Currently, surgery, usually supplemented with other adjunctive therapies, is the only potentially curative treatment modality for rectal cancer. There are tree common types of radical resection of rectal carcinoma: abdominoperineal resection (Miles procedure), low anterior resection (Dixon procedure) and Hartmann’s procedure. This paper summarized the nursing management of a rectal cancer patient with skin mucous membrane separation after Hartmann’s procedure. The enterostomal therapist carried out skin care, dressing management, home-based care and psychological care, in order to treat complications of enterostomy and improve the rehabilitation of the patient. (目前手术切除是治疗结直肠癌的主要方法, 同时辅以放疗化疗等综合治疗方法。直肠癌根治术分为3种: Miles术、Dixon术、Hartmann术。本文总结1例直肠癌患者行Hartmann术后肠造口皮肤黏膜分离的护理体会。肠造口治疗师通过皮肤护理、敷料选择、患者及其家属居家护理以及心理护理, 解决患者肠造口并发症, 促进患者康复, 提高生活质量。

Measurement of integrated luminosity of data collected at 3.773 GeV by BESIII from 2021 to 2024

We present a measurement of the integrated luminosity e+e- of collision data collected by the BESIII detector at the BEPCII collider at a center-of-mass energy of Ecm = 3.773 GeV. The integrated luminosities of the datasets taken from December 2021 to June 2022, from November 2022 to June 2023, and from October 2023 to February 2024 were determined to be 4.995±0.019 fb-1, 8.157±0.031 fb-1, and 4.191±0.016 fb-1, respectively, by analyzing large angle Bhabha scattering events. The uncertainties are dominated by systematic effects, and the statistical uncertainties are negligible. Our results provide essential input for future analyses and precision measurements